Malignant Melanoma and Papillon-Lefèvre Syndrome

Hacham‐Zadeh, Shoshana; Goldberg, Leonard Harry

doi:10.1001/archderm.1982.01650130006003

Cited by 16 publications

(5 citation statements)

References 2 publications

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“…32 An interesting finding in our case is the predominance of oval-and spindle-shaped melanoma cells with desmoplastic features. Cases reported by Seike et al 32 and Hacham-Zadeh et al 33 also showed predominance of oval-and spindle-shaped cells with no other risk factor for the development of melanoma. 32,33 This may suggest a predisposition to malignant melanoma in hyperkeratotic plaques.…”

Section: Discussionmentioning

confidence: 79%

“…Cases reported by Seike et al 32 and Hacham-Zadeh et al 33 also showed predominance of oval-and spindle-shaped cells with no other risk factor for the development of melanoma. 32,33 This may suggest a predisposition to malignant melanoma in hyperkeratotic plaques. It might be relevant to look at the melanocytes in involved plaques by immunohistochemical and ultrastructural methods.…”

Section: Discussionmentioning

confidence: 79%

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Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Dessureault

Poulin

Bourcier

et al. 2003

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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An association between malignant epithelial tumors and Olmsted syndrome has already been reported. The association of malignant melanoma with other types of palmoplantar keratodermas has been reported. This may suggest a predisposition to melanocytic as well as squamous cell malignancies in congenital keratodermas. Oral retinoids appear to be the most promising treatment for Olmsted syndrome and for other symptomatic keratodermas.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 79%

Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Dessureault

Poulin

Bourcier

et al. 2003

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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“…Hacham-Zader et al [8] described a 31-year-old man with Papillon-Lefèvre syndrome (PLS) who developed melanoma in an affected finger. PLS is an autosomal recessive PPK that differs from de Meleda by the presence of associated symptoms of premature loss of nail bed, an increased susceptibility to infections (20% of cases), and disorders of leucocyte function with alteration of polymorph nuclear leukocyte motility and bactericidal function.…”

Section: Discussionmentioning

confidence: 99%

Malignant melanoma developing in an area of hereditary palmoplantar keratoderma (Mal De Meleda)

Mozzillo¹,

Nunziata²,

Caracò³

et al. 2003

Journal of Surgical Oncology

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Palmoplantar keratoderma (PPK) refers to a genetically heterogeneous group of skin diseases, which may be inherited in autosomal dominant or recessive fashion. We observed a case of a 74-year-old man with Mal de Meleda, who developed malignant melanoma inside the hyperkeratotic palmar skin of the right hand. Many authors have reported a higher incidence of cancer in cases affected by palmoplantar hyperkeratosis both for hereditary association and particularly for mechanical damage of the affected areas. The association with melanoma has already been described, but not in a true Mal de Meleda type syndrome as in the case reported in this paper.

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“…The cases of skin cancer documented in both English and Spanish literature involved individuals aged over 31 years. [12][13][14][15][16] However, our study had a limited representation of participants above this age threshold, comprising only four individuals. This discrepancy suggests a potential sampling bias.…”

Section: Discussionmentioning

confidence: 99%

Self‐reported clinical features and treatment effectiveness of Papillon–Lefèvre syndrome patients from five Latin American countries: A cross‐sectional online survey study

Alfaro‐Sepúlveda,

Salinas,

Valenzuela

et al. 2024

Aust J Dermatology

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Background/ObjectivesMost studies about Papillon–Lefèvre syndrome (PLS) are limited to case reports and patients of the same nationality. This study aimed to determine the self‐reported prevalence of signs, symptoms and treatment effectiveness in PLS patients from five Latin American countries.MethodsAn online survey was conducted among adult and paediatric patients from Mexico, Argentina, Colombia and Brazil. Data were collected using multiple‐choice, open‐ended and image‐chooser questions on demographics, signs and symptoms, perceived treatment effectiveness and quality of life.ResultsSeventeen patients (10 males and 7 females) aged 4–47 years were surveyed. All had palmoplantar hyperkeratosis. Other affected sites were the feet and hand dorsum (82.35%), Achilles tendon (88.24%), forearms (58.82%), legs (29.41%) and glutes (23.53%). They frequently presented hyperhidrosis and nail pitting. Four had a history of delayed umbilical cord separation. All used topical treatments, with moderate effectiveness; half used oral retinoids, perceived as highly effective. Most reported decreased quality of life and walking difficulties.ConclusionsThe study's results align with prior research on PLS, but reveal new insights, including the impact on patients' quality of life and a history of delayed umbilical cord separation. These findings warrant consideration in future research and patient care.

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Malignant Melanoma and Papillon-Lefèvre Syndrome

Cited by 16 publications

References 2 publications

Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Malignant melanoma developing in an area of hereditary palmoplantar keratoderma (Mal De Meleda)

Self‐reported clinical features and treatment effectiveness of Papillon–Lefèvre syndrome patients from five Latin American countries: A cross‐sectional online survey study

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