Malignant melanoma in situ associated with underlying sarcoidal granuloma: A histopathological mimicker of invasive epithelioid melanoma cells

Abstract

Malignant melanoma is known to show diverse cellular morphologies, including a histiocyte-like morphology. Therefore, many non-melanocytic proliferations or infiltrates can mimic melanoma, and be confusing especially when they coexist with a true melanoma. Herein, we report an unusual case of a melanoma in situ with an underlying sarcoidal granuloma, which mimicked dermal invasion of melanoma. This case expands insight into nonneoplastic lesions closely mimicking melanoma.

Dermatofibrosarcoma protuberans coexisting with sarcoid reaction in a patient with sarcoidosis

“…She had a history of hypertension, hyperlipidemia, Patients with sarcoidosis may incidentally develop sarcoma or malignant melanoma, which histopathologically forms a sarcoidal granuloma adjacent to the tumor. 2,3 In this patient, sarcoidal granulomas were embedded within the tumor mass. Although DFSP may develop in a patient with sarcoidosis, this is the first report of DFSP coexisting with sarcoidal granulomas in a patient with sarcoidosis.…”