Malignant melanoma of the gallbladder

Anderson, Jamie; Hughes, R G; Williamson, Rcn

doi:10.1136/pgmj.59.692.390

Cited by 17 publications

(5 citation statements)

References 2 publications

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“…Apart from this, a case was also reported to have metastasized to the common bile duct at operation, [ 21 ] and 2 cases metastasized to the jejunum. [ 18 , 22 ]…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the gallbladder with multiple metastases

Wang

Su²,

Ma³

et al. 2017

Medicine

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Rational:Primary malignant melanoma of the gallbladder is an extremely rare tumor, with fewer than 40 cases reported in the literature worldwide. The majority of patients presented as a solitary lesion in the gallbladder. To our knowledge, only one case of primary malignant melanoma of the gallbladder with multiple metastases has been reported, which involved the stomach, duodenum, pancreas, jejunum and a mesenteric lymph node.Patient concerns:We report a case of primary malignant melanoma of the gallbladder with metastases to the duodenal bulb, right adrenal and a celiac lymph node.Diagnoses:Primary malignant melanoma of the gallbladder with multiple metastases.Interventions:Gastrojejunostomy, cholecystectomy, and biopsy of the three metastatic lesions were performed. Histopathologic examination revealed melanin pigments were within the tumor cells of the four lesions, however, junctional activity was noted only in the gallbladder, supporting that the gallbladder was the primary site. No pigmented lesions were detected on the skin or eyes. The postoperative recovery was uneventful, and subsequently, chemotherapy with paclitaxel and carboplatin was administered.Outcomes:The patient survived for 16 months due to tumor. progression.Lessons:The current case was unique due to the adrenal involvement. For patients with multiple metastases of malignant melanoma, gallbladder origin should be considered in the differential diagnosis from cutaneous origin.

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“…Apart from this, a case was also reported to have metastasized to the common bile duct at operation, [ 21 ] and 2 cases metastasized to the jejunum. [ 18 , 22 ]…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the gallbladder with multiple metastases

Wang

Su²,

Ma³

et al. 2017

Medicine

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“…There are no characteristic laboratory findings in GBM. Anemia [10,27,36,93], leukocytosis [8,18,28,33,39,41,62,71,73,83,86,94], elevated erythrocyte sedimentation rate (ESR) [24], elevated bilirubin [8,44,46,83,89], and elevated liver enzymes [8,12,46,51,59,63,70,75,83,84,86,89] were reported. Also the presence of occult blood in stool sample may be found in cases with haematobilia or coexistence of intestinal metastases [27].…”

Section: Signs Symptoms and Laboratory Findingsmentioning

confidence: 99%

“…Anemia [10,27,36,93], leukocytosis [8,18,28,33,39,41,62,71,73,83,86,94], elevated erythrocyte sedimentation rate (ESR) [24], elevated bilirubin [8,44,46,83,89], and elevated liver enzymes [8,12,46,51,59,63,70,75,83,84,86,89] were reported. Also the presence of occult blood in stool sample may be found in cases with haematobilia or coexistence of intestinal metastases [27]. There is a single publication when the serum level of novel melanoma marker -5-S-cysteinyldopa was useful in establishing the diagnosis [13].…”

Section: Signs Symptoms and Laboratory Findingsmentioning

confidence: 99%

Melanoma of the gallbladder

2023

Folia Medica Cracoviensia

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Melanoma is a highly malignant neoplasm with the most typical primary locations in the skin and eyeball and rarely reported in the other organs, including the gallbladder. More commonly metastases of melanoma of various primary sites to the gallbladder are observed. However, generally melanoma of the gallbladder is a rare entity with only 217 cases reported in the literature up to date. The paper summarizes knowledge on epidemiology, symptoms, laboratory and imaging findings, morphology, treatment options, and outcome of patients with both primary and metastatic melanoma to the gallbladder.

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“…[1][2][3][4][5][7][8][9][10][11][12][13][15][16][17]29 When metastases are limited to the gallbladder, the prognosis improves significantly. In our series, these patients achieved 100% survival at 1 year, with 2 living 9 years past the diagnosis, compared with 0% for those with unresectable tumors.…”

Section: 1% Of Cases (4 Of 19) With Primary Lesions and Inmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] As is true for other mucosal melanomas, most of these patients are in their fourth or fifth decade of life at the time of diagnosis. 17 The mainstay of therapy is surgical excision, with no clear role for adjuvant modalities at this time.…”

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confidence: 99%