Malignant melanoma of the lacrimal sac

Malik, Tahira Y; Sanders, R C; Young, James D.; Brennand, E; Evans, Andrew

doi:10.1038/eye.1997.232

Cited by 14 publications

(17 citation statements)

References 8 publications

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“…There was no significant difference between genders, but the mean age at the time of diagnosis was 64 years for men, and 55 years for women 5. They have an insidious onset and may present like chronic dacryocystitis 6 7. Presenting features were lacrimal symptoms such as epiphora or blood-stained reflux.…”

Section: Discussionmentioning

confidence: 94%

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Primary malignant melanoma of the lacrimal sac

Li¹,

Zhu

Zhang

et al. 2012

BMJ Case Reports

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Primary malignant melanoma of the lacrimal sac is extremely rare. It is usually diagnosed at an advanced stage after excision or biopsy of a tumour. We treated a 59-year-old man with tearing and bloody discharge from the right eye. Clinical examination revealed a firm, localised mass at the inner canthus consistent with a lacrimal sac swelling. Sac washout demonstrated obstruction to entry into the lacrimal sac with a reflux of blood-stained fluid. The pathological findings and the immunohistochemical studies showed a malignant melanoma of the lacrimal sac. We performed radical surgery and radiation therapy. Follow-up 4 months after surgery revealed no evidence of recurrence. Because this tumour often presents with symptoms similar to dacryocystitis and may masquerade as a chronic dacryocystitis, ophthalmologists should be aware of this disease entity when encountered with patients with epiphora and mass in the medial canthal area.

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Section: Discussionmentioning

confidence: 94%

“…The treatment varies with size and extent of the tumour, and may range from only dacryocystectomy to wide en-bloc resection, postoperative radiotherapy, chemotherapy and immunotherapy in a variety of combinations 6. Local recurrence of mucosal malignant melanoma of the head and neck region has been a major factor in treatment failure.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the lacrimal sac

Li¹,

Zhu

Zhang

et al. 2012

BMJ Case Reports

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“… 7 The role of ART in lacrimal sac melanoma remains unclear due to the rarity of this disease. 3 Approximately 17 cases of malignant melanoma of the lacrimal sac treated with ART have been reported in the literature ( Table 1 8 – 16 ). Our first patient did not undergo ART and remained disease-free, while our second patient was found to have distant metastases during ART.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for malignant melanoma of the lacrimal sac

2020

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Malignant melanoma of the lacrimal sac is an exceptionally rare tumor with a poor prognosis. We report two cases of malignant melanoma of the lacrimal sac: a 73 year-old female treated with primary surgical resection and a 75 year-old male treated with surgical resection, adjuvant proton beam radiotherapy, and adjuvant immunotherapy. We discuss the role of post-operative proton beam therapy and recent advancements in immunotherapy. These cases highlight the importance of early diagnosis and multi-modality treatment in this aggressive malignancy.

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“…1 Lacrimal sac tumors have an insidious onset and limited early visibility and may mimic chronic dacryocystitis, resulting in delayed diagnosis. 6,7 Typically, patients have the clinical triad of epiphora, blood-stained reflux from the lacrimal punctum, and a mass in the region of the medial canthus. 8,9 The usual sequence of events was epiphora, followed by recurrent bouts of dacryocystitis, a mass in the medial canthal area, and finally, epistaxis and involvement of the preauricular, submandibular, and cervical lymph nodes.…”

Section: Discussionmentioning

confidence: 99%