Malignant melanoma of the prostate gland: A systematic review

Caputo, Alessandro; Addesso, Maria; Zeppa, Pio; D’Antonio, Antonio

doi:10.1016/j.prp.2021.153594

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…The same has been reported with melan-A. S-100 expression has been reported in 67% of primary and 100% of secondary prostatic melanoma [ 6 , 10 ]. Systemic therapies include chemotherapy, targeted therapy, and immunotherapy.…”

Section: Discussionsupporting

confidence: 78%

“…Out of prostatic melanomas, primary cases represent only a minority. Approximately three out of four prostatic melanomas are metastases from another site [ 6 , 7 ]. Patients with primary prostatic melanoma are usually younger (median, 51.5 years) than those with metastatic melanoma in the prostate (median, 66 years).…”

Section: Discussionmentioning

confidence: 99%

“…Most primary cases present with lower urinary tract symptoms (LUTS), while 75% of metastatic prostatic melanoma have LUTS. This could be in metastatic melanoma; the lesion may be small and peripheral and may not be impinging on the urethra [ 6 ]. The most likely origin of primary prostatic melanoma is the prostatic urothelium.…”

Section: Discussionmentioning

confidence: 99%

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Primary malignant melanoma of prostate: a case report

Masood¹,

Sharma²,

Sood³

et al. 2023

Pan Afr Med J

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While primary genitourinary melanomas account for less than 1% of all melanoma cases, prostatic melanoma is extremely uncommon. These patients are challenging to identify, with a dismal prognosis. We reported a 52-year-old male patient who presented with lower urinary tract symptoms in the last one and a half months. The patient underwent Holmium laser enucleation of the prostate, and the histopathology result of the resected specimen showed prostatic melanoma. Investigations for systemic melanoma evaluation were negative, and the patient underwent radical cystoprostatectomy, urethrectomy, and bilateral lymph node dissection. The patient refused chemotherapy, developed lung metastasis shortly after surgery at three months, and succumbed to the metastatic disease with overall survival of 6 months. In conclusion, primary malignant melanoma of the prostate is a very rare disease. The most logical therapeutic strategy is aggressive surgical resection, followed immediately by adjuvant therapy.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Primary malignant melanoma of prostate: a case report

Masood¹,

Sharma²,

Sood³

et al. 2023

Pan Afr Med J

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“…Because of this variable morphology, other prostatic neoplasms such as leiomyosarcoma, rhabdomyosarcoma and sarcomatoid carcinoma should always be excluded [9] , [10] , [11] . Malignant melanoma can involve the whole genitourinary tract including the prostate, both as a primary neoplasm and by metastasizing from other sites [12] , [13] . Due to its protean morphology, including possible sarcomatoid aspects, it should be ruled out too [14] , [15] .…”

Section: Discussionmentioning

confidence: 99%

Prostatic stromal sarcoma: Report of a rare case in a young male and review of the literature

Addesso¹,

Caputo²,

Zeppa³

et al. 2023

International Journal of Surgery Case Reports

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“…In a systematic review presented in 2021 [ 66 ], it was found that from a total of 25 studies describing 45 cases, the majority of prostate cancer cases were metastases, with only 10 cases of primary prostate cancer. With a wide range, the median age of patients was 61 years, and 89% were symptomatic at presentation, most commonly with obstructive symptoms (83%).…”

Section: Main Findings Of the Literature (Review) Questmentioning

confidence: 99%

Intra-Abdominal Malignant Melanoma: Challenging Aspects of Epidemiology, Clinical and Paraclinical Diagnosis and Optimal Treatment—A Literature Review

et al. 2022

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According to European consensus-based interdisciplinary guidelines for melanoma, cutaneous melanoma (CM) is the most deadly form of dermatological malignancy, accounting for 90% of the deaths of skin cancer patients. In addition to cutaneous melanoma, mucosal melanoma occurs in four major anatomical sites, including the upper respiratory tract, the conjunctiva, the anorectal region, and the urogenital area. As this cancer type metastasizes, a classification used in the current medical literature is the distinction between secondary lesions and primary malignant melanoma of the abdominal cavity. Given that malignant melanoma is the most common cancer that spreads to the gastrointestinal tract, different imaging modalities compete to diagnose the phenomenon correctly and to measure its extension. Treatment is primarily surgery-based, supported by immunotherapy, and prolongs survival, even when performed at stage IV illness. In the end, special forms of malignant melanoma are discussed, such as melanoma of the genito-urinary tract and amelanotic/achromic melanoma. The importance of this present literature review relies on yielding and grouping consistent and relevant, updated information on the many aspects and challenges that a clinician might encounter during the diagnosis and treatment of a patient with intra-abdominal melanoma.

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Malignant melanoma of the prostate gland: A systematic review

Cited by 8 publications

References 29 publications

Primary malignant melanoma of prostate: a case report

Primary malignant melanoma of prostate: a case report

Prostatic stromal sarcoma: Report of a rare case in a young male and review of the literature

Intra-Abdominal Malignant Melanoma: Challenging Aspects of Epidemiology, Clinical and Paraclinical Diagnosis and Optimal Treatment—A Literature Review

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