Malignant Melanoma of the Urethra: A Rare Histologic Subdivision of Vulvar Cancer with a Poor Prognosis

Alkatout, İbrahim; Lež, Cvjetko; Altarac, Silvio; Fureš, Rajko; Čupić, Hrvoje; Peršec, Zoran; Hrgović, Zlatko; Mundhenke, Christoph

doi:10.1155/2012/385175

Cited by 18 publications

(26 citation statements)

References 29 publications

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“…Sometimes, small urethral MMs are erroneously removed by local excision, since they may resemble caruncle. Distal urethrectomy following the excision did not reveal a residual tumor [16]. Amelanotic melanoma is a rare form of the urethral MM, and often resembles urethral caruncle.…”

Section: Discussionmentioning

confidence: 86%

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Primary malignant melanoma of the female urethra − a case report

Hadži-Djokić

Vasić

Bašić³

et al. 2018

Med pregl

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Introduction. Malignant melanoma accounts for 3% of all cancers in Europe. Malignant melanoma of the genitourinary tract is very rare, accounting for 1% of all cases. In addition, primary malignant melanoma of the urethra accounts for 0.2% of all melanomas and 4% of all urethral cancers. The abnormal migration of melanocytes during the embryonic development may explain their occurrence in the urethra. Also, vulva contains a relatively high concentration of melanocytes, so it may be the reason for higher incidence of malignant melanomas in females than in males, especially located at the meatus or in the distal urethra. Case Report. A 60-year-old woman presented with a solid tumor protruding through the vaginal introitus. Computerized tomography revealed a 5 cm large tumor of the urethra, infiltrating the bladder neck and the anterior vaginal wall. In addition, a bilateral pelvic lymphadenopathy was observed. The patient underwent anterior pelvic exenteration with urethrectomy, bilateral pelvic lymphadenectomy and bilateral ureterocutaneostomy, followed by immunochemotherapy. Nonetheless, the patient died 10 months after the surgery. Conclusion. Urethral melanoma is a tumor with a very poor prognosis and high recurrence rate (71%), even after wide surgical resection, adjuvant radiotherapy, chemo and immunotherapy.

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Section: Discussionmentioning

confidence: 86%

“…The most common tumors of the female urethra are squamous cell carcinoma (60%) and transitional cell carcinoma (20%), while MM accounts for less than 2% of all cases [15]. In addition, female urethral MM comprises less than 0.2% of all melanomas [16].…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the female urethra − a case report

Hadži-Djokić

Vasić

Bašić³

et al. 2018

Med pregl

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“…Most vulvar squamous cell carcinomas are determined by the origin of the vulvar epidermis; most injuries develop in the labia, especially the labia majora (2). Over 80% of recurrences are in the first 2 years after therapy and may be local or remote (3). Although treatment of the primary lesion is well established, surgical treatment of recurrent local-regional lesions poses difficulties in excision, and more so in reconstruction.…”

Section: Discussionmentioning

confidence: 99%

“…The debut of vulvar cancer varies in age; however, the majority of cases occur in women over 50, and the maximum incidence is between 65 and 70 years of age (2). Histologically, more than 85% of vulvar malignancies are squamous cell carcinomas (2,3). Surgery is the main pillar of vulvar cancer therapy, but is also reserved for tumours that have not extended beyond the vulva (4).…”

Section: Introductionmentioning

confidence: 99%

Recurrent vulvar carcinoma: complex surgical treatment via perineal excision and reconstruction with musculocutaneous flap

Popa¹,

Obleagă²,

Paitici³

et al. 2018

JMMS

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Vulvar cancer is a malignant disease having a low frequency and with well-established surgical and oncological treatments based on the stage of the disease. The most important therapeutic problem encountered is represented by cases of perineal local regional recurrence, which are common in patients with large primary tumors and can occur even if the margins of the resection had no tumoral invasion. We present a case study of a 64-year-old patient diagnosed one year ago with squamous vulvar carcinoma (G3) for which a vulvectomy was performed after neoadjuvant radiotherapy. The patient later developed local recurrence with invasion of the anal sphincter, creating a delicate problem regarding a surgical approach. The size and the extent of the recurrent tumor required a complex surgical intervention using a mixed surgical team of general surgeons and plastic surgeons. Surgical intervention with a large excision of the recurrent cancer along with amputation of the inferior rectum via perineal route, and creation of a left iliac anus was performed. The perineal defect was covered via a musculocutaneous flap using the gracilis muscle. The immediate post-operative evolution was favorable.

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“…The current recommendation is that a more individualized and conservative approach should be used to treat such patients [13].…”

Section: Discussionmentioning

confidence: 99%