2012
DOI: 10.4070/kcj.2012.42.4.278
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Malignant Melanoma of Unknown Primary Origin Presenting as Cardiac Metastasis

Abstract: Malignant melanoma has a very high propensity to metastasize to the heart. However, melanoma may sometimes present as a metastatic lesion in the absence of a primary lesion, which are called melanomas of unknown primary origin. We report a case in which a patient presented with a metastatic maligant melanoma in the right atrium with pericardial effusion and without a primary origin.

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Cited by 11 publications
(6 citation statements)
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“…However, currently there is no standard approach to the treatment of cardiac metastases associated with malignant melanoma. No collective experience has currently been shown to improve long term survival following the surgical resection of an isolated cardiac melanoma [3] . Nevertheless, the resection of an isolated cardiac melanoma tumor may be an effective palliative measure in selected patients and may enhance the effectiveness of adjuvant therapies.…”
Section: Discussionmentioning
confidence: 99%
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“…However, currently there is no standard approach to the treatment of cardiac metastases associated with malignant melanoma. No collective experience has currently been shown to improve long term survival following the surgical resection of an isolated cardiac melanoma [3] . Nevertheless, the resection of an isolated cardiac melanoma tumor may be an effective palliative measure in selected patients and may enhance the effectiveness of adjuvant therapies.…”
Section: Discussionmentioning
confidence: 99%
“…Melanomas may rarely present as cardiac metastases in the absence of the primary lesion and are described as melanoma of unknown primary origin [2] . Surgical resection of cardiac metastasis has not been shown to influence long term survival in melanoma patients, although it can relieve cardiac symptoms and prevent further comorbidities [3] . A patient with metastatic malignant melanoma of unknown primary origin is presented as an incidental cardiac mass that underwent surgical resection of the cardiac metastasis.…”
Section: Introductionmentioning
confidence: 99%
“…It is broadly described in literature. The capricious presentations of the disease itself can be found in different reports, for example: 1.7 kg lymph node axillary metastasis [1], lung metastasis [2], right atrial metastasis with pericardial effusion [3], midbrain und inguinal metastases [4], skin -colored skin-fixed noduli with inguinal mass, rectal wall metastasis, lung metastasis and liver metastases [5], adrenal metastasis with subcutaneous metastatic focus [6], or simply in form of inguinal swelling that presents itself via enlarged lymph node. All of these are advocates of either the melanoma regression theory, or transformation theory, which includes the appearance of aberrant melanocyte within the lymph node [7].…”
Section: Introductionmentioning
confidence: 99%
“…They can appear extremely rapidly, within a few heartbeats [1], and can even be found in trauma deaths with nearly immediate circulatory arrest [2]. These are commonly seen in sudden profound hypotension, either from severe blood loss or from "shock" in the widest sense [1,3], and, even more often, in combination with brain injuries [4]. These hemorrhages were sometimes termed "shock lesions", or named after Sheehan [5].…”
Section: Introductionmentioning
confidence: 99%
“…However, cardiac metastases are diagnosed in about 1% of patients with malignant melanomas because nearly one-tenth of these patients present with cardiac symptoms [4]. The identification of cardiac metastases arising from melanomas usually demonstrates that systemic metastases are the reason of suffering in patients.…”
Section: Introductionmentioning
confidence: 99%