Malignant meningioma: An indication for radiotherapy

Dziuk, Timothy W.; Woo, SangKeun; Butler, E. Brian; Goodman, Christopher D.; Harper, R. A. Kemp; Narayan, Ravishwar; Ji, Thornby; Dennis, W. Sam; Han, Lu; Carpenter, L. Steven; Chiu, J. Kam; Munkarah, M.

doi:10.1016/0360-3016(93)90851-l

Cited by 79 publications

(142 citation statements)

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“…There was a clear tendency toward a progressively higher frequency of malignant meningiomas among recurrent tumor 13 . Malignant meningiomas were tumors that had undergone reoperation and had originally been either benign or aggressive meningioma.…”

Section: Discussionmentioning

confidence: 92%

“…According Dziuk et al 13 adjuvant irradiation following initial resection increased the 5-years disease free survival rates from 15% to 80% (p=0.002); when administered for recurrent lesions, adjuvant radiotherapy improved the 2-years disease free survival from 50% to 89% (p=0.015), but had no impact on 5-years disease free survival; the authors concluded that extent of resection, adjuvant radiotherapy, and recurrence status are independent prognostic factors.…”

Section: Radiation Therapymentioning

confidence: 99%

“…Dziuk et al 13 reported a disease free/progression free survival at 5 years was 39% following total resection versus 0% after subtotal resection (p=0.001) in patient with malignant meningioma; they stated that complete surgical resection is crucial for longterm control.…”

Section: Surgerymentioning

confidence: 99%

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Anaplastic meningioma: case report

Falavigna

Santos

Chimelli

et al. 2001

Arq. Neuro-Psiquiatr.

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-Intracranial meningiomas continue to challenge our best clinical efforts to eliminate them once discovered and deemed appropriate for treatment. Malignant meningiomas constitute 10% to 15% of all meningiomas and limited information exists regarding adjuvant treatment. The external whole brain irradiation is recommended. Traditional chemotherapy has proven ineffective; thus, new chemotherapeutic agents and new methods of delivery should be developed. Immunotherapy may be considered for patients with malignant meningiomas when all others previous treatment have failed. We report a case of anaplastic papillary meningioma. A 67-year-old man presented with partial complex seizures, headache and aggressiveness. A computerized tomography and magnetic resonance image demonstrated a large left temporo-occipital mass with difuse contrast enhancement and extensive surrounding edema. A left temporo-occipital flap was performed. The tumor and the infiltrated dura were radically removed. Postoperatively, the patient remained neurologically intact. The treatment was complemented by external whole brain radiation.KEY WORDS: papillary meningioma, pathology, radiotherapy, chemotherapy. Meningioma anaplásico: relato de casoRESUMO -O tratamento adequado para os pacientes com meningiomas intracranianos continua sendo um desafio, principalmente o de sua variante maligna, a qual tem incidência de 10% a 15%, sem uma certeza do melhor tratamento adjuvante. É indicado o uso da radioterapia externa holocraniana. O uso da quimioterapia tradicional se mostra ineficaz, havendo necessidade de estudos para desenvolver outros agentes quimioterápicos e novos métodos de administração desses agentes no tumor cerebral. A imunoterapia pode ser considerada para os casos de refratariedade aos outros tratamentos adjuvantes. Relatamos o caso de um paciente de 67 anos, com história progressiva de cefaléia, crises convulsivas parciais complexas e agressividade. A investigação radiológica com tomografia computadorizada e ressonância magnética evidenciaram um processo expansivo na região temporoccipital esquerda com contrastação difusa e edema peritumoral importante. Foi realizada craniotomia frontoparietotemporal esquerda com remoção radical da dura-máter infiltrada e do tumor. O paciente evoluiu sem déficit neurológico no pós-operatório. O exame anatomopatológico foi compatível com meningioma maligno do tipo papilar. Foi instituído tratamento complementar com radioterapia externa holocraniana.PALAVRAS-CHAVE: meningeoma papilar, patologia, radioterapia, quimioterapia. Meningioma, one of the most common types of brain tumors in adults, remains a clinical problem yet to be solved by neurologist, neurosurgeons and oncologists. Meningiomas constitute 15% to 20% of all primary brain tumor and 10% to 15% of all meningioma are considered malignant 1,2 . These tumors will recur after standard therapies of surgical excision, radiation therapy, radiosurgical techniques, and chemotherapy 1,3-6 .We report a case of papillary meningioma, considered be analast...

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Section: Discussionmentioning

confidence: 92%

Section: Radiation Therapymentioning

confidence: 99%

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Anaplastic meningioma: case report

Falavigna

Santos

Chimelli

et al. 2001

Arq. Neuro-Psiquiatr.

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“…On MRI, meningioma's are typically isodense, dura-based masses that often show homogeneous enhancement. [8]There was a clear tendency toward a progressively higher frequency of anaplastic meningioma's among recurrent tumor [13]. Anaplastic meningioma's were tumors that had undergone reoperation and had originally been either benign or aggressive meningioma.…”

Section: Discussionmentioning

confidence: 99%

A rare intracranial tumor of Psammomatous anaplastic meningioma

Harihar

Bhadbhade

Murthy

2016

Int J of Biomed & Adv Res

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Intracranial meningiomas continue to challenge our best clinical efforts to eliminate them once discovered and deemed appropriate for treatment. Malignant meningiomas constitute 10% to 15% of all meningiomas and limited information exists regarding adjuvant treatment. The external whole brain irradiation is recommended. Traditional chemotherapy has proven ineffective; thus, new chemotherapeutic agents and new methods of delivery should be developed. Immunotherapy may be considered for patients with malignant meningiomas when all others previous treatment have failed. We report a rare case of Psammomatous anaplastic meningioma. A 45-year-old man presented with head ache since 15 days and vomiting since 13days. Magnetic resonance image demonstrated a large left frontal mass with heterogenous enhancement and moderate peri-lesional edema. The tumor and the infiltrated dura were radically removed. Postoperatively, the patient remained neurologically intact.

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“…One retrospective study of 38 patients with 48 malignant meningioma resections (28 total and 20 subtotal) was done to determine the time to recurrence, among other parameters (Dziuk et al, 1998). Twenty-five lesions were treated at initial presentation and 23 were treated as recurrent disease (13 had transformed from previously benign meningiomas).…”

Section: Extent Of Resection and Tendency For Recurrencementioning

confidence: 99%