Malignant Mesothelioma Mortality — United States, 1999–2015

Mazurek, Jacek M.; Syamlal, Girija; Wood, John; Hendricks, Scott; Weston, Ainsley

doi:10.15585/mmwr.mm6608a3

Cited by 127 publications

(124 citation statements)

References 7 publications

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“…Diffuse malignant mesothelioma is a rare but highly aggressive malignancy of serosal membranes . The initial diagnosis is made on biopsy specimens and usually requires a panel of confirmatory immunohistochemical markers .…”

Section: Introductionmentioning

confidence: 99%

“…Diffuse malignant mesothelioma is a rare but highly aggressive malignancy of serosal membranes. [1][2][3][4][5][6][7][8] The initial diagnosis is made on biopsy specimens and usually requires a panel of confirmatory immunohistochemical markers. 9 The classification of mesothelioma into epithelioid, sarcomatoid, and biphasic types is based on the presence of epithelioid histology, sarcomatoid histology, or both histologies in the tumor and has been shown to have prognostic value.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of biopsy sampling in predicting histology in patients with diffuse malignant pleural mesothelioma

Chirieac

Hung

Foo

et al. 2019

Cancer

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Background The classification of diffuse malignant mesothelioma into epithelioid, biphasic, and sarcomatoid types is based on histologic patterns. The diagnosis is made on biopsies, and because of intratumoral heterogeneity, they may not be representative of the entire tumor. The number and volume of biopsies needed to reach diagnostic accuracy in diffuse malignant mesothelioma and their prognostic value remain unclear. Methods This study examined 759 consecutive patients with pleural diffuse malignant mesothelioma treated by pleurectomy/decortication or extrapleural pneumonectomy for the presence of epithelioid and/or sarcomatoid histology and classified both the presurgery biopsies (core‐needle or thoracoscopic) and surgical resection specimens. The number and volume of biopsies were correlated with pre‐ and postsurgery histologies and overall survival. Results Diffuse malignant mesothelioma was classified as epithelioid (76%), biphasic (18%), sarcomatoid (5%), or indeterminate (1%) in biopsies and as epithelioid (64%), biphasic (32%), and sarcomatoid (4%) in surgical resection specimens (overall concordance, 80.6%). The positive likelihood ratios were 2.4, 13.6, and 90.1 for biopsies with epithelioid, biphasic, and sarcomatoid histologies, respectively. Concordant histologies between biopsies and resections were associated with a higher number of biopsies (median tissue blocks for concordant histologies vs discordant histologies, 3 vs 2; P < .002) but were less associated with a higher volume (median, 1.2 vs 1.1 cm3; P = .06). In a multivariate analysis, overall survival was independently predicted by histology in the resection specimen (P < .0001) but not in the biopsy (P = .09). Conclusions In contrast to epithelioid histology, sarcomatoid histology in biopsies is highly accurate. Despite intratumoral heterogeneity, the accuracy of histologic classification increases with the number of tissue blocks examined, emphasizing the diagnostic value of extensive sampling by presurgery biopsies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic value of biopsy sampling in predicting histology in patients with diffuse malignant pleural mesothelioma

Chirieac

Hung

Foo

et al. 2019

Cancer

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“…Of further note, Canada has implemented legislation to ban asbestos use by 2018 (7). In the United States significant asbestos abatement via regulatory actions of the Environmental Protection Agency have served to limit asbestos exposure as much as practical to the general public (8).…”

Section: Introductionmentioning

confidence: 99%

“…Further, the latest analysis from the Centers for Disease Control and Prevention observed that the annual number of deaths from mesothelioma continued to unexpectedly increase by 4.8% (P for linear time trend <0.001) overall to 2,579 cases in 2015. And the underlying main factor for this rise was increased deaths among persons aged ≥85 years (8). In other countries, current predictions of MPM incidence have not yet reached peak levels.…”

Section: Introductionmentioning

confidence: 99%

In vitro experimental models of mesothelioma revisited

Singh

Pruett

Hoang

2017

Transl. Lung Cancer Res.

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“…Various occupations associated with asbestos exposure, such as insulation workers and shipyard builders, demonstrate increased risks for developing malignant mesothelioma (3).…”

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confidence: 99%