Malignant Mesothelioma of the Tunica Vaginalis Testis in a Dog: Histological and Immunohistochemical Characterization

Vascellari, Marta; Carminato, Antonio; Camali, Giovanni; Melchiotti, Erica

doi:10.1177/104063871102300125

Cited by 22 publications

(20 citation statements)

References 12 publications

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“…As mesotheliomas often show transcoelomic spread, the dog most likely developed implantation metastasis along the peritoneum as reported previously (Cihak and others 1986, Vascellari and others 2011, Ramírez and others 2013). …”

Section: Discussionsupporting

confidence: 65%

“…In human beings, mesotheliomas of the tunica vaginalis comprise 0.3–5 per cent of all mesotheliomas (Murai 2001). In dogs, they are rarely described (Cihak and others 1986, Vascellari and others 2011, Ramírez and others 2013). In both cases, a swelling of the scrotum was evident and on sonography an inhomogeneous mass was seen in the inguinal canal as was accumulation of fluid in the vaginal process and scrotum.…”

Section: Discussionmentioning

confidence: 99%

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A rare case of a mesothelioma in the tunica vaginalis of a dog

Schäfer-Somi¹,

Richter

Flickinger³

2016

Vet Record Case Reports

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A 14-year-old American Staffordshire cross was presented with a history of enlargement of the right testicle of two months duration. Findings included hormonally active testicular tumour, epididymitis, unilateral hydrocele of the right testicle and bilateral testicular atrophy; furthermore, benign prostate gland hypertrophy or prostatitis and balanoposthitis was also present; this variety hampered diagnosis. Radiographs of the lungs and abdominal ultrasound did not reveal any metastatic disease. After two weeks of antibiotics and NSAIDs, bilateral castration and radical excision of the testicular cords were performed. During surgery, an infiltrative growing mass of the testicular cord was observed and hindered complete removal. Histological examination of the excised tissue revealed mesothelioma of the right and left tunica vaginalis testis and a presumably oestrogen-secreting Leydig cell tumour of the left testicle with secondary bilateral testicular atrophy. The dog's condition deteriorated within the following two months. Diagnostic work-up and treatments are discussed.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

A rare case of a mesothelioma in the tunica vaginalis of a dog

Schäfer-Somi¹,

Richter

Flickinger³

2016

Vet Record Case Reports

View full text Add to dashboard Cite

show abstract

“…In numerous researches conducted on both canine and human cases, immunohistochemistry performed on tissue samples and immunocytochemistry performed on cellular samples of mesotheliomas have revealed constant expression of intermediate filaments typical for both epithelial and mesenchymal cells (Hurlimann 1994, Höinghaus et al 2008, Espino et al 2010, Gumber et al 2011, Vascellari et al 2011. However, simple co-expression of these two intermediate filaments cannot be used as a marker of neoplastic mesothelial cells, since co-expression of cytokeratin and vimentin in the same cells has been detected also in other types of tumors, for example synovial sarcomas, haemangiosarcomas, mammary gland carcinomas (Desnoyers et al 1990, Rabanal andElse 1994).…”

Section: Discussionmentioning

confidence: 99%

Using of immunocytochemistry in differential diagnosis of neoplasms of serosal cavities in dogs

Przeździecki¹,

Sapierzyński²

2014

Polish Journal of Veterinary Sciences

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The presence of tumor within the serosal cavities, often connected with accumulation of serosal effusion, is a quite common problem in the small animal veterinary medicine. The first step in diagnosis of such cases is cytopathological examination. The aim of the present study was to evaluate the usefulness of cytology and immunocytochemistry, using commercially available antibodies (anti-cytokeratin, anti-vimentin, and anti-desmin), in differential diagnosis of malignant tumors located within serosal cavities in dogs. The final cytological diagnosis of carcinoma/adenocarcinoma, sarcoma, and mesothelioma was obtained on the basis of routine cytopathology and immunocytochemistry, and then confirmed by histopathology and immunohistochemistry. Cytoplasmic immunoreactivitiy of normal mesothelid cells and cytoplasmic immunoreactivity of hyperplastic mesothelial cells revealed constant and strong expression of all examined intermediate filaments: cytokeratin, vimentin and desmin. Application of routine cytopathology and immunocytochemistry allowed 32 neoplastic tumors to be detected: 19 cases of carcinomas/adenocarcinomas, 6 cases of sarcomas, 7 cases of mesotheliomas. Immunostaining of cytopathological samples with chosen set of antibodies: anti-cytokeratin, anti-vimentin, anti-desmin is a useful, and low invasive test for differentiation between mesotheliomas and carcinomas/adenocarcinomas in dogs.

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“…Interstitial cell tumors are composed of small nodules that may be singular or become confluent to form large nodular masses; they are poorly encapsulated and are yellowish, soft, and greasy on cut surface. [68][69][70][71][72] The ultrasonographic appearance of testicular neoplasms varies and is not specific for tumor type (Figures 17-33 to [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Sertoli cell tumors often cause testicular enlargement and are associated with feminizing syndrome and bone marrow suppression due to high estrogen production.…”

Section: Neoplasiamentioning

confidence: 99%