Malignant mesothelioma of the tunica vaginalis testis: A rare cause of hydrocele

Peixoto, Murilo de Sá Barrêto Callou; Soares, Mateus Kleinsorgen Bernardo; Libânio, Bruna Brandão; Albuquerque, Kamila Seidel; Bacchi, Carlos E.

doi:10.1016/j.eucr.2022.102048

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…The accurate diagnosis of MM of the spermatic cord is crucial but rarely achieved preoperatively, posing a challenge for patient management [12,13]. Most cases of MM of the spermatic cord are determined intraoperatively and present with papillary excrescences or fibrotic thickening of tunica vaginalis with or without hemorrhagic hydrocele fluid [8].…”

Section: Discussionmentioning

confidence: 99%

Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms

2024

JOMH

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Paratesticular malignant mesothelioma (MM) is a rare tumor frequently associated with asbestos exposure. Therefore, we present an even rarer case of a 78-year-old male patient diagnosed with multiple primary neoplasms, including prostate cancer, lung cancer, paratesticular MM, and upper tract urothelial carcinoma. The patient initially presented with a painless testicular mass and had a notable medical history of prostate and lung cancers. Following physical examination and an ultrasound evaluation, he underwent radical right inguinal orchiectomy, which revealed paratesticular MM. The patient's lung cancer recurrence and subsequent treatment coincided with periods of no MM recurrence. However, after the lung cancer treatment, the MM recurred multiple times within short intervals. This unique case indicates that systemic treatments for lung cancer, specifically cisplatin-based chemotherapy and atezolizumab immunotherapy, might also have an anti-tumor effect on paratesticular MM. Although MM combined with multiple primary neoplasms is challenging to treat and frequently recurs, treatments for other malignancies, as evidenced in this case, may have suppressive effects on the recurrence and metastasis of MM.

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Section: Discussionmentioning

confidence: 99%

Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms

2024

JOMH

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“…It can occur at any age; however, the majority of patients are between 55 and 75 years of age, with occasional cases in adolescents ( 3 ). Since its first recording in 1957, <300 cases have been reported worldwide ( 4 , 5 ). The most common clinical manifestation of this disease is scrotal enlargement with an unexplained hydrocele; a small number of patients present with internal scrotal masses and pain in the inguinal area ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

A rare malignant mesothelioma of the tunica vaginalis testis: A case report

Jiang,

Cai,

et al. 2024

Oncol Lett

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Malignant mesothelioma of the tunica vaginalis testis is a rare, highly invasive urogenital malignant tumor with no specific clinical manifestations. Reported cases of this disease are limited. Therefore, an early preoperative diagnosis is difficult. The current study presents a case of malignant mesothelioma of the tunica vaginalis testis and a literature review. A 52-year-old man was admitted to Xiaoshan Affiliated Hospital of Wenzhou Medical University (Hangzhou, China) in December 2022 and underwent radical resection of the right testicle and epididymis but did not undergo radiotherapy or chemotherapy. The patient was followed up for 5 months, and no recurrence or metastasis was found. The rarity of testicular mesothelioma poses a challenge to its etiology and diagnosis, which is rarely achieved preoperatively. Malignant mesothelioma of the testicular tunica vaginalis has a poor prognosis and is not sensitive to radiotherapy or chemotherapy, requiring close postoperative follow-up. This condition is rare in clinical practice; therefore, it needs to be reported to aid clinicians' decision-making regarding diagnosis and treatment.

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Malignant Para-Testicular Mesothelioma: A Rare Presentation in the Tunica Vaginalis of an Elderly Male With No Prior Asbestos Exposure

Shaker,

Blankenship,

Shaker

et al. 2024

Int J Surg Pathol

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Malignant mesothelioma of the tunica vaginalis is an extremely rare and aggressive tumor that is frequently encountered in elderly patients. The diagnosis of malignant mesothelioma of the tunica vaginalis poses a diagnostic challenge due to its infrequency and nonspecific clinical presentation. Histopathological examination and immunohistochemical staining are essential in differentiating this tumor from other para-testicular masses and establishing a definitive diagnosis. Early detection and comprehensive treatment planning are crucial for improving the prognosis and overall outcomes for patients with this rare malignancy. We present a report of malignant mesothelioma of the tunica vaginalis in a 78-year-old male patient with no history of asbestos exposure who presented with a large infiltrative left para-testicular mass. Histopathological examination revealed a biphasic proliferation composed of epithelioid and spindle cells with infiltrative features, foci of necrosis, and increased mitotic figures. Immunohistochemical staining exhibited positive staining for WT1, D2-40, and calretinin, supporting the mesothelial origin of the tumor. Notably, BerEP4 staining was negative, arguing against carcinoma. Immunostaining for keratin 5 was positive, supporting the mesothelial differentiation. The Ki67 proliferation index was high. The differential diagnosis included adenomatoid tumors, germ cell tumors, and pleomorphic sarcoma. We aim to discuss the clinical presentation, diagnostic approach, and therapeutic approaches of this rare entity.

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Malignant mesothelioma of the tunica vaginalis testis: A rare cause of hydrocele

Cited by 4 publications

References 4 publications

Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms

Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms

A rare malignant mesothelioma of the tunica vaginalis testis: A case report

Malignant Para-Testicular Mesothelioma: A Rare Presentation in the Tunica Vaginalis of an Elderly Male With No Prior Asbestos Exposure

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