Malignant mixed mesodermal tumors of the ovary

DiSilvestro, Paul; Gajewski, W; Ludwig, Mark; Kourea, Helen; Sung, James L.; Granai, C.O.

doi:10.1016/0029-7844(95)00285-y

Cited by 21 publications

(11 citation statements)

References 8 publications

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“…2,7,12 Further prognostic factors for OS, such as age and depth of myometrial invasion have been previously described. 10,26 Median age of 69 years in our study (menopausal women) was however coherent with the literature, 1,4,11,12,35,36 (25) and myometrial invasion was a significant prognostic factor in the univariate analysis. Differences may be partially explained by the surgical procedures employed in our data set of patients.…”

Section: Discussionsupporting

confidence: 86%

Uterine and Ovary Carcinosarcomas

Pacaut¹,

Bourmaud²,

Rivoirard³

et al. 2015

American Journal of Clinical Oncology

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Section: Discussionsupporting

confidence: 86%

Uterine and Ovary Carcinosarcomas

Pacaut¹,

Bourmaud²,

Rivoirard³

et al. 2015

American Journal of Clinical Oncology

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“…It is highly aggressive and rapidly progressive with a poor long‐term prognosis. The median survival rate of the patients was only 7–13 months with more than 70% of the patients dying of the disease at 1 year after diagnosis 2–4 . Prognostic factors that influence the clinical outcome remain controversial due to the rarity of this tumour.…”

Section: Introductionmentioning

confidence: 99%

Malignant mixed mullerian tumour of the ovary: Prognostic factor and response of adjuvant platinum‐based chemotherapy

Inthasorn

Beale

Dalrymple

et al. 2003

Aust NZ J Obst Gynaeco

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“…The nosological concept is equally debated between various authors. These tumors have received a variety of appellations, such as mixed mullerian (mesodermal) tumors when seen in the female genital tract, 7,8 but carcinosarcomas when they occur in the lung, liver or prostate. [9][10][11] Neoplasms of the breast that are identical to these tumors are not usually designated as carcinosarcomas, but rather are referred to as metaplastic carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Stomach with Heterologous Elements

Khan

1999

Ann Saudi Med

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We report a unique sarcomatoid carcinoma of the stomach that, in addition to having carcinomatous and sarcomatous components, also contained foci of heterologous cartilaginous differentiation. Gastric sarcomatoid carcinomas were reviewed by Iezzoni and Mills, but cartilaginous differentiation was not seen in any of their 30 cases.1 Robey-Cafferty and associates have also reported three cases, but none of them contained heterologous cartilaginous elements.2 One case report from Korea, however, mentions the presence of cartilage in a carcinosarcoma of the stomach. Case ReportA 46-year-old Saudi man was admitted to Asir Central Hospital with recent onset of dyspepsia, anorexia and weight loss. An endoscopic examination of the stomach was performed and a biopsy was taken. This initial biopsy was unsuccessful in demonstrating the tumor. On explorative laparotomy, however, a large tumor was found, necessitating total gastrectomy and splenectomy.The gastrectomy specimen measured 22 cm in length and 9 cm in diameter across the body of the stomach. When the stomach was opened along the greater curvature, a large ulcer was noted in the antral region, measuring 4x3 cm. The margins of the ulcer were edematous and elevated, with loss of mucosal rugosities around its circumference. The wall of the stomach beneath the ulcerated lesion was thickened (2.5 cm), with grayish-white homogeneous cut surfaces. Six lymph nodes were found along the greater curvature of the stomach, ranging in size from 0.4 to 0.9 cm in maximal dimension. The spleen measured 10x5.5x4 cm, and was grossly unremarkable. Microscopically, the ulcerated lesion of the stomach showed a biphasic tumor invading the full thickness of its wall. The tumor was composed of two distinct components, one being a moderately differentiated adenocarcinoma and the other being a sarcoma (Figure 1).The carcinomatous component consisted of irregular glands that were lined by stratified columnar cells containing hyperchromatic nuclei. These neoplastic glands were separated from each other by a sarcomatous stroma of pleomorphic spindle-shaped cells exhibiting frequent mitotic figures. There were clear-cut foci of chondroid differentiation among the sarcomatous elements, exhibiting significant nuclear atypia. Transition between carcinomatous and sarcomatous components was not seen, but the sarcomatous foci merged imperceptibly with cartilaginous foci. The tumor invaded deeply in the muscularis propria. A random section taken at a distance from the main tumor displayed foci of intestinal metaplasia and dysplasia. Gastric margins of resection, the lymph nodes and spleen were not involved by the tumor. DiscussionChondroid differentiation is rare in sarcomatoid carcinomas of the stomach, but it is not uncommon in those tumors that arise from the esophagus, small intestine 1 and colon. 5 In the 30 cases reviewed by Iezzoni and Mills, 1 the average age of the patients with gastric sarcomatoid carcinoma was 52 years, and 64% were males. These tumors arose from all portions of the stomach...

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Malignant mixed mesodermal tumors of the ovary

Cited by 21 publications

References 8 publications

Uterine and Ovary Carcinosarcomas

Uterine and Ovary Carcinosarcomas

Malignant mixed mullerian tumour of the ovary: Prognostic factor and response of adjuvant platinum‐based chemotherapy

Sarcomatoid Carcinoma of the Stomach with Heterologous Elements

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