Malignant mixed müllerian tumor of the fallopian tube

Malignant mixed mullerian tumour of the fallopian tube occurring in a patient with Peutz–Jegher's syndrome

“…In 1993, Weber et al reviewed 52 cases of MMMT of the fallopian tube that had been reported in published works thus far. 10 A recent search on published work revealed 15 additional cases; 7,9,[11][12][13][14][15] thus, only 67 cases of primary MMMT of the fallopian tube have been reported.…”

“…There is growing evidence that adjuvant platinum-based chemotherapy, which has been shown to be of benefit in cases of adenocarcinoma of the fallopian tube 18,19 used alone or in combination with adjuvant radiotherapy may also improve survival in cases of tubal MMMT. 5,[7][8][9][10]12,17,20 Gemcitabine has been shown to be useful in treating recurrent ovarian cancer as well as platinum-refractory ovarian and fallopian tube cancers. [21][22][23] Histologically, MMMT are biphasic tumours which are composed of an intimate mixture of carcinomatous components (usually well-differentiated or poorly differentiated adenocarcinoma) and sarcomatous elements.…”

“…11 However, apart from the single case of disseminated carcinosarcoma occurring in a 14-year-old girl reported in 1926, the tumour has not been described in children and, until the present case, has only been reported in women over the age of 35. [7][8][9][10][11][12][13][14][15][16][17] Patients commonly present with abdominal pain and vaginal bleeding/discharge and preoperatively, most patients are diagnosed as having ovarian tumours. 11 Fewer than half the patients present with Stage 1 (FIGO staging of ovarian cancer) disease, the remainder presenting with advanced disease.…”