Malignant mixed müllerian tumors of the uterus

Williamson, E. O.; Christopherson, William M.

doi:10.1002/1097-0142(197203)29:3<585::aid-cncr2820290309>3.0.co;2-1

Cited by 66 publications

(15 citation statements)

References 16 publications

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“…Carcinosarcomas occur mainly in women ~15-17 years after menopause (4,8,9), with the most common symptoms being genital bleeding and uterine enlargement (10). Abdominal pain also occurs in a proportion of the cases (11).…”

Section: Discussionmentioning

confidence: 99%

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Carcinosarcoma of the uterus: A case report

Adachi

Nonogaki

Minamiguchi

et al. 2016

Molecular and Clinical Oncology

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Abstract. Carcinosarcoma is a rare malignant tumor of the uterus with a poor prognosis. We herein present a case of uterine carcinosarcoma in a 67-year-old woman suffering from pervaginal bleeding for 3 months, with progressive anemia. Upon biopsy of the endometrium, the tumor was diagnosed as endometrioid adenocarcinoma. Total hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection were performed. The histological examination revealed that the tumor consisted of serous adenocarcinoma and sarcoma of homologous components. After the operation, chemotherapy with paclitaxel and carboplatin was administered. At approximately 3 years postoperatively, the patient remains alive and recurrence-free.

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Section: Discussionmentioning

confidence: 99%

“…Carcinosarcomas of the uterus (malignant mixed Müllerian tumors) are a rare occurrence, accounting for only 2-5% of all uterine malignancies (1)(2)(3)(4). Carcinosarcomas are, however, highly aggressive, and are composed of epithelial and mesenchymal elements (5).…”

Section: Introductionmentioning

confidence: 99%

Carcinosarcoma of the uterus: A case report

Adachi

Nonogaki

Minamiguchi

et al. 2016

Molecular and Clinical Oncology

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“…Other authors did not find statistically significant differences in survival between homologous and heterologous tumors and concluded that the prognosis of these tumors is essentially the same (6,13,25,28,32,41,42,46,50,65,68,74,81,82,84,85,89).…”

Section: Prognosismentioning

confidence: 96%

Mixed Mullerian tumors of the uterine corpus: a review

Ali

Wells

1993

International Journal of Gynecological Cancer

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“…This distinction between types was emphasized in the past by the,use of different terms: carcinosarcoma for homologous tumors and mixed mesodermal tumor for heterologous neoplasms (1). The occurrence of malignant mixed mullerian tumors in man is well documented (2,6,12), while the tumors have not been observed in domestic or laboratory animals up to now. Rhabdomyosarcomas of the uterus in man can occur either as a constituent of malignant mixed mullerian tumors or as pure rhabdomyosarcomas.…”

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confidence: 99%

Spontaneous Malignant Mixed Müllerian Tumors and Rhabdomyosarcoma of the Uterus in Rats

Kaspareit-Rittinghausen¹,

Deerberg²

1990

Toxicol Pathol

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Five malignant miied miillerian tumors and one rhabdomyosarcoma were observed in LEWIS rats. Heterologous mullerian neoplasms (cases 1 4 ) consisted of epithelial and mesenchymal elements including squamous epithelium, glandular epithelium and sarcomatous, rhabdomyosarcomatous, cartilaginous as well as OSS~OUS parts. All the heterologous tumors revealed undifferentiated areas with an anaplastic appearance. The homologous miillenan tumor (case 5 ) was composed of glandular epithelium embedded in sarcomatous tissue. The rhabdomyosarcoma (case 6) consisted of bundles of elongated strap-like cells mixed with cells resembling rhabdomyoblasts.Keywords. Uterus tumors; mixed mesodermal tumors; carcinosarcoma; embryonal rhabdomyosarcoma; histopathology; LEWIS rats Malignant mixed mullerian tumors are characterized by an admixture of malignant epithelial and mesenchymal elements. If the stromal component is an undifferentiated sarcoma, the neoplasm is designated as homologous. Heterologous mixed mullerian tumors are those that also contain chondrosarcomatous, osteosarcomatous and/or rhabdomyosarcomatous parts (5). This distinction between types was emphasized in the past by the,use of different terms: carcinosarcoma for homologous tumors and mixed mesodermal tumor for heterologous neoplasms (1). The occurrence of malignant mixed mullerian tumors in man is well documented (2, 6, 12), while the tumors have not been observed in domestic or laboratory animals up to now. Rhabdomyosarcomas of the uterus in man can occur either as a constituent of malignant mixed mullerian tumors or as pure rhabdomyosarcomas. The latter tumor type is rare (3,7) and occurs predominantly in children (8, 9). The only case of rhabdomyosarcoma of the uterus in animals has been reported in a one-year-old quarter horse filly (1 1). The histogenesis of mixed mullerian tumors and uterine rhabdomyosarcomas in man is still uncertain. An origin from either pluripotent persisting remnants of the primitive mesoderm of mullerian ducts (7, 10) or from metaplasia (3, 7) of endometrial stroma have been mainly discussed. In the present report, we describe the histopathological features of heterologous (cases 1-4) and homologous (case 5 ) malignant mixed mullerian tumors as well as of an uterine rhabdomyosarcoma (case 6). To our knowledge, there are no doc-* umented reports of these uterine tumor types in rats or other laboratory animals. The tumor-bearing rats belonged to a colony of LEW/Han rats (300 males, 300 females) kept in a longevity-study from weaning to their natural death. They were housed in groups of 5 (separated according to sex) in polycarbonate cages in an animal room at 22 f 1°C room temperature, 55 f 5% relative humidity, 15 mm H20 atmospheric pressure, with a 12: 12 hr light-dark sequence and an air exchange rate of 20 times per hr. All rats were fed an autoclaved, cereal-based diet ad libittiin. Acidified and pasteurized tap water was continually available. The breeding colony of LEWIS rats is examined routinely and the rats arc known to...

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Malignant mixed müllerian tumors of the uterus

Cited by 66 publications

References 16 publications

Carcinosarcoma of the uterus: A case report

Carcinosarcoma of the uterus: A case report

Mixed Mullerian tumors of the uterine corpus: a review

Spontaneous Malignant Mixed Müllerian Tumors and Rhabdomyosarcoma of the Uterus in Rats

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