Malignant myoepithelioma of the parapharyngeal space — a case report

Ramachandran, K.; Mohankumar, Venugopal; Suma, R; Naseer, K. C.

doi:10.1007/s12070-008-0042-9

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…Myoepitheliomas of the salivary glands are rare tumours that occur mostly in the parotid gland [1,4,5]. However, other head and neck sites of origin such as the submandibular gland [19,20] oral cavity [21], palate [3,4,[22][23][24][25] larynx [26,27], parapharyngeal space [28], nasopharynx [29][30][31][32], maxillary sinus [33], external auditory canal [34] have, rarely, been reported in the literature. MMs have also been, sporadically, reported in unusual locations, e.g., the breast [35][36][37], bone [38][39][40] skin [41] and vulva [42].…”

Section: Reviewmentioning

confidence: 99%

“…Histologically, MMs are composed of one or several cell types: spindle, plasmacytoid, epithelioid and clear cells [23]. The mean age of presentation is 62 years [1] and a slow-growing painless mass is usually involved [28].…”

Section: Reviewmentioning

confidence: 99%

“…Complete resection with wide margins is considered essential and has given favourable outcomes for salivary gland myoepitheliomas [5,14,22]. Until now the mainstay of treatment has been surgery [22,28]. Malignant myoepithelial cell-rich lesions require a wider local excision and lymph node dissection [49].…”

Section: Reviewmentioning

confidence: 99%

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Malignant Myoepithelioma of the Parotid Gland: Literature Review on the Occasion of Our Report of a Case

Kyrgias¹,

Kalogeridi²,

Tzitzikas³

et al. 2012

IJCM

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Malignant myoepitheliomas are rare malignant salivary gland neoplasms which usually occur in the parotid gland. Very little material on this topic has been published. This tumour represents a therapeutic challenge since there are no specific recommendations or guidelines. We present a case of malignant myoepithelioma arising de novo in the parotid gland. We discuss our therapeutic approach and considerations on appropriate post-surgical treatment. Then we provide a review of international literature on this interesting and rare oncological entity

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Malignant Myoepithelioma of the Parotid Gland: Literature Review on the Occasion of Our Report of a Case

Kyrgias¹,

Kalogeridi²,

Tzitzikas³

et al. 2012

IJCM

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“…Myoepithelial carcinoma (MC), also known as malignant myoepithelioma, is a rare salivary gland malignancy that accounts for fewer than 1% of salivary gland tumors, most commonly arising in the parotid gland [1,2]. MC tends to occur in middle-aged individuals, with a median age of diagnosis ranging from 51 to 61 years, with no clear gender predominance [3,4].…”

Section: Introductionmentioning

confidence: 99%

Primary Parotid Tumor Thrombosis: Immunohistologic Features and Awareness of Metastatic Potential

Dekhou¹,

Rehman²,

Parzen³

et al. 2021

Cureus

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Tumor thrombosis is a poor prognostic feature and an exceptionally rare occurrence in salivary gland malignancies. We present a case of primary parotid myoepithelial carcinoma (MC) with tumor thrombosis in the external jugular vein (EJV). An 82-year-old man presented with a right-sided facial mass. MRI with and without gadolinium demonstrated a mass of the right parotid gland with a filling defect of the right EJV. The patient underwent right parotidectomy and selective neck dissection. Tumor thrombosis was found intraoperatively within the EJV. Final pathology demonstrated a poorly differentiated MC. Adjuvant radiation therapy without concurrent systemic therapy was administered. Three months later, restaging positron emission tomography (PET) with CT revealed numerous bilateral pulmonary nodules with biopsy, demonstrating poorly differentiated MC without locoregional relapse. Given that primary parotid tumor thrombosis is associated with a poor prognosis, the use of early systemic therapy should be investigated.

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Salivary gland myoepithelial carcinoma

et al. 2015

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Salivary gland myoepithelial carcinoma (MC) or malignant myoepithelioma is a rare entity. MC usually presents as a slow-growing painless mass arising in the parotid gland, but may involve other salivary glands. This tumour may be particularly locally aggressive, but its clinical and biological features are not yet fully understood. MC may arise from pre-existing benign lesions, such as pleomorphic adenomas or benign myoepitheliomas, or may arise de novo. It usually affects patients over 50 years old, with no gender preference. Because it is often asymptomatic, the presentation and diagnosis can be delayed by months, even years. The current WHO classification considers MC to be an intermediate- to high-grade malignancy. Other published data suggest it is likely to be a high-grade neoplasm, consistent with its aggressive behaviour. Its epidemiology, histopathological features, immunohistochemical profile, clinical behaviour and optimal management are not well understood. Following review of the current literature we aim to address these.

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Malignant myoepithelioma of the parapharyngeal space — a case report

Cited by 4 publications

References 5 publications

Malignant Myoepithelioma of the Parotid Gland: Literature Review on the Occasion of Our Report of a Case

Malignant Myoepithelioma of the Parotid Gland: Literature Review on the Occasion of Our Report of a Case

Primary Parotid Tumor Thrombosis: Immunohistologic Features and Awareness of Metastatic Potential

Salivary gland myoepithelial carcinoma

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