Malignant Neoplasia in Four Alpacas

Sartin, Eva A.; Crowe, David R.; Whitley, Elizabeth M.; Treat, Robert E.; Purdy, Stephen R; Belknap, Ellen B.

doi:10.1177/104063870401600309

Cited by 26 publications

(68 citation statements)

References 14 publications

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“…26 PMRCTs were most likely to exhibit a packeted appearance on histopathology, and their cells were often a relatively homogeneous population of bland cells with minimal pleomorphism, as has been previously described. 26 However, the appearance of cells of PMRCTs was variable, and tumor morphology on routinely stained sections did not accurately differentiate tumor types in this study.…”

Section: Discussionsupporting

confidence: 57%

“…It is possible that tumors that failed to express any of these markers could still be lymphoma, but the expression of 1 or more neural markers in tumors in this group makes this unlikely. Results of this and prior studies of camelid tumors suggest that B-cell lymphoma is more common than T-cell lymphoma 10,23,26 and that approximately 25% of malignant round cell tumors in camelids are PMRCTs. 26 PMRCTs were most likely to exhibit a packeted appearance on histopathology, and their cells were often a relatively homogeneous population of bland cells with minimal pleomorphism, as has been previously described.…”

Section: Discussionmentioning

confidence: 59%

“…Results of this and prior studies of camelid tumors suggest that B-cell lymphoma is more common than T-cell lymphoma 10,23,26 and that approximately 25% of malignant round cell tumors in camelids are PMRCTs. 26 PMRCTs were most likely to exhibit a packeted appearance on histopathology, and their cells were often a relatively homogeneous population of bland cells with minimal pleomorphism, as has been previously described. 26 However, the appearance of cells of PMRCTs was variable, and tumor morphology on routinely stained sections did not accurately differentiate tumor types in this study.…”

Section: Discussionmentioning

confidence: 59%

“…26 B-cell and T-cell markers allowed for differentiation of B-cell and T-cell lymphoma. It is possible that tumors that failed to express any of these markers could still be lymphoma, but the expression of 1 or more neural markers in tumors in this group makes this unlikely.…”

Section: Discussionmentioning

confidence: 99%

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Malignant Round Cell Neoplasia in Llamas and Alpacas

et al. 2009

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Malignant round cell neoplasia was identified in 12 llamas and 12 alpacas aged 0-23 years. Mean age of affected alpacas (3.1 years) was significantly less than that of affected llamas (8.0 years). Tumor cell morphology varied from large and often pleomorphic (11 tumors) to small and often homogeneous (13 tumors). Neoplastic lesions were multicentric in 12 cases. Other sites were gastric (5 cases), intra-abdominal (perirenal; 4 cases), intrathoracic (2 cases), and cervical (1 case). Immunohistochemistry with antibodies to CD79alpha, BLA36, and CD3 identified B-cell lymphoma (12 cases) and T-cell lymphoma (6 cases). Six tumors did not express any lymphoid marker and were further immunostained for neuron-specific enolase (NSE), synaptophysin, S-100, glial fibrillary acidic protein (GFAP), and chromogranin A. All 6 of these tumors were negative for GFAP and chromogranin A but expressed 1 or more of the neural markers NSE, synaptophysin, and S-100 and were classified as primitive malignant round cell tumors (PMRCT). Tumor types could not be distinguished on the basis of animal age, gross pathologic appearance, tumor morphology, or tumor location. All animals with lymphoma and 5 with PMRCT died or were euthanatized. One alpaca with a focal cervical PMRCT lived for at least 20 months after diagnosis. Results of this study indicate that malignant round cell tumors in llamas and alpacas are a heterogeneous group that cannot be distinguished on the basis of signalment, postmortem findings, or routine light microscopic findings. Immunohistochemistry is a valuable diagnostic procedure when evaluating malignant round cell neoplasia in llamas and alpacas.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Malignant Round Cell Neoplasia in Llamas and Alpacas

et al. 2009

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“…Most cases of SAC lymphoma described in the literature are multicentric, with formed masses within the abdominal and/or thoracic cavities, and multifocal to locally extensive masses in visceral organs, including the liver, stomach, kidneys, heart, lungs, and lymph nodes. 8,9,11,16,18,20 In SACs, cutaneous lymphoma has only previously been reported in 2 animals. The first case involved a 1.5-year-old female alpaca with multifocal subcutaneous lymphoma widely distributed over the body.…”

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confidence: 99%

Pagetoid reticulosis (epitheliotropic cutaneous T-cell lymphoma) in an adult alpaca (Vicugna pacos)

Hasbach

Stern

2016

J VET Diagn Invest

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A 9-year-old, intact female alpaca ( Vicugna pacos) was presented for a second opinion with a 1-year history of nonpruritic, multifocal scaling and crusted cutaneous lesions, mainly involving skin on the face, axillae, and ventral abdomen. Clinical abnormalities were limited to the skin, and the alpaca was otherwise healthy. The initial veterinarian had examined the alpaca, found no evidence of ectoparasites with laboratory testing, and had tried several trial therapies including oral antibiotics, ivermectin, and topical use of betadine solution. At the time of presentation, the lesions had neither improved nor worsened with any attempted therapy, and multiple skin biopsies were collected. Histopathology and immunohistochemical staining findings were consistent with the pagetoid reticulosis type of cutaneous epitheliotropic T-cell lymphoma. Our report describes the clinical, histopathologic, and immunophenotypic features of pagetoid reticulosis epitheliotropic cutaneous T-cell lymphoma in an alpaca.

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Multisystem Disorders

and¹,

Bravo²

2010

Medicine and Surgery of Camelids

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Malignant Neoplasia in Four Alpacas

Cited by 26 publications

References 14 publications

Malignant Round Cell Neoplasia in Llamas and Alpacas

Malignant Round Cell Neoplasia in Llamas and Alpacas

Pagetoid reticulosis (epitheliotropic cutaneous T-cell lymphoma) in an adult alpaca (Vicugna pacos)

Multisystem Disorders

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