Malignant neoplasms of the nasal cavities and paranasal sinuses: (A retrospective study)

Abstract

This study presents a retrospective look at 115 patients evaluated here from 1957 to 1974. In this series, 57 percent were males and 43 percent females, 84 percent were Caucasian and 16 percent Negro. Lesions confined to or originating in the antrum made up 67 percent while non‐antral lesions were 33 percent. Mean age at diagnosis was 59.1 years. Smoking and drinking history did not appear to be contributory. Antral lesions were retrospectively staged according to Sisson's TNM classification. Sixteen tumor types were involved, with the most common being epidermoid. Diagnosis was most often made by intranasal or Cald‐well‐Luc biopsy. Most frequent symptoms, as well as earliest symptoms, were nasal obstruction, localized pain, and epistaxis. Average duration of symptoms was 6.4 months. Therapy was generally in the form of radiotherapy alone, preoperative radiotherapy and surgery, surgery and postoperative radiotherapy, or surgery alone. Local recurrences occurred in 44 percent of antral lesions and 50 percent of non‐antral lesions. Regional (cervical) nodal metastases developed in 25 percent of antral lesions and 11 percent of non‐antral lesions. Distant metastases developed in 30 percent of antral cases and 35 percent of non‐antral cases. Five‐year survival was 32 percent (35 percent determinate) for the total group. The more advanced the staging of the antral lesions, the worse the prognosis. Best survival figures were in the areas of preoperative radiotherapy and surgery at 38 percent (43 percent) and surgery alone at 56 percent (59 percent).

Nasal and paranasal sinus carcinoma: Are we making progress?

“…The difference was highly significant in the log-rank analysis, as suggested in previous reports. 17,66,76,95,96,104,111,134,135,139,154,167,169,180 The meta-analysis confirmed that surgery (70%) and combined surgery and radiation (56%) offer better local control and cure rates than radiotherapy alone (33%). Most series, including ours, are biased in patient selection, and no randomized study has been published.…”

“…This was noted in previous articles on patients with primary tumors of the maxillary sinus. 5,90,92,95,104,117,126,137,144,154,155,157,162,173 Our 5-year CSAS rates were 91%, 64%, 70%, and 50% for patients with T1, T2, T3, and T4 tumors, respectively. These results are close to the meta-analysis data from the 1990s for patients with T1 tumors (94%) and T2 tumors (55%), but they are much better compared with the results for patients with T3 tumors (50%) and T4 tumors (27%).…”

Progressive Unilateral Nasal Congestion, Facial Pain, and Vision Change in an Immunocompetent Patient

“…Prior reviews 1,2 suggest that certain presenting symptoms, such as unilateral pain, swelling, numbness, epistaxis, diplopia, and decreased vision, are more common in patients with sinonasal malignant neoplasm. Certain findings on CT scans may also be suggestive of etiology.…”

Carcinosarcoma of the Orbit: Report of Two Cases and Review of the Literature

“…[15][16][17][18][19][20][21][22][23][24][25][26] We identified 5 cases of carcinosarcoma that originated in the maxillary sinus or ethmoid sinus with extension into the orbit. 15,16,19,23,26 These cases are summarized in Table 2.…”