Malignant Neoplasms of the Nasopharynx

The Relationship of the Virus to Nasopharyngeal Carcinoma

“…Light microscope studies have led to the view that all NPCs should be regarded as squamous cell carcinomas (New and Kirch, 1928;Hauser and Brownell, 1938;Tech, 1957;Yeh, 1962;) and this has been further supported by electron microscope studies (Svoboda et al, 1965(Svoboda et al, , 1967Lin et al, 1969;Gazzolo etal., 1972;Shanmugaratnam, 1972;Prasad, 1974) which showed the presence of desmosomes between adjacent tumor cells, and tonofibrils and keratin-like structures within the cytoplasm of tumor cells from different types ofNPC. In addition to squamous cell-derived NPC, other histologic types of carcinoma may arise from columnar and transitional cell epithelia (Liang etal., 1962;Ho, 1972;Klein etal., 1974), possibly without preceding squamous metaplasia.…”

Cancer of the Nasopharynx

“…In many otherwise excellent papers 33 the end results are based on survivals for varying periods of less than five years or on only those patients who were traced, so that actual five year end result figures cannot be accurately determined.…”

Klinik virusbedingter Tumoren

“…Bereits 1928 waren New und Kirch [291] der Meinung, daB es sich bei den Lymphoepitheliomen und Transitionalzell-Karzinomen urn Varianten des Plattenepithelkarzinoms handelte. Diese Ansicht wurde spater auch von anderen Pathologen geteilt [65,99,150,151,238,248,375,436,452]. In der alteren Literatur wurden diese undifferenzierten Tumoren, die nach den heutigen Erkenntnissen mit Sicherheit epithelialer Herkunft sind, falschlicherweise als Endotheliome [255,410], zervikale Lymphosarkome [403], Iymphozytoplastische Sarkome [38].…”

“…Hirnnerven eintreten [264]. [33,126,138,151,219,305,402,426]. Die Ursache fUr die Verzogerung der Diagnose ist nicht nur in der versteckten Lage des Nasenrachens zu suchen, sondern vor allem in der Unkenntnis der klassischen vier Symptomgruppen.…”