Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study

Sugimoto, T.; Wakizono, S.; Uemura, Takuya; Tsuneyoshi, Masazumi; Enjoji, Munetomo

doi:10.1017/s0022215100122194

Cited by 35 publications

(19 citation statements)

References 22 publications

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“…4,[7][8][9]23 Malignant forms of oncocytomas or oncocytic carcinomas, characterized by cytomorphologically malignant oncocytes or evidence of metastasis, are occasionally reported and account for Ͻ1% of all salivary gland tumors. 1,3,6,14,24,25 These are usually associated with a preexisting oncocytoma but may arise de novo. 3 No histologic features of malignancy were detected in our series, and none of the 7 patients who underwent surgery showed clinical features of disease recurrence following surgery.…”

Section: Discussionmentioning

confidence: 99%

CT Features of Parotid Gland Oncocytomas: A Study of 10 Cases and Literature Review

Tan¹,

Tan²

2010

AJNR Am J Neuroradiol

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SUMMARY:Oncocytomas of the salivary glands are rare benign epithelial tumors which occur most commonly in the parotid gland. The aim of our study was to characterize the clinical-radiologicpathologic spectrum of parotid oncocytomas in a series of 10 cases seen in our institution between January 2003 and November 2008. The CT features of parotid oncocytomas in the largest imaging series of this rare but important benign lesion include a well-defined enhancing tumor with a "deformable" appearance when large, and a non-enhancing curvilinear cleft or cystic component. These CT findings are potentially helpful in distinguishing these benign lesions from other parotid tumors in clinical scenarios that preclude surgical resection or when biopsy results are non-diagnostic. Further studies are advocated to validate the specificity and positive predictive value of these imaging features.O ncocytomas of the salivary gland, which were first described by Jaffé in 1932, are benign epithelial tumors that occur most commonly in adults in their sixth to eighth decades, [1][2][3][4][5][6] with no clear sex predilection. 3,4,[6][7][8][9] These neoplasms are histologically composed of monotonous sheets of oncocytes, epithelial cells named by Hamperl in 1931, which are characterized by an intensely eosinophilic and granular cytoplasm. These metabolically altered epithelial cells accumulate numerous cytoplasmic mitochondria through the process of oncocytic metaplasia. 1,4,5,7,[10][11][12] Synonyms for this tumor include oncocytic adenoma, oxyphilic granular-cell adenoma, and oxyphilic adenoma.Oncocytomas are rare, comprising just 0.5%-1.5% of salivary gland tumors. 4,[7][8][9][13][14][15][16] The parotid gland is the most commonly involved salivary gland, accounting for 78%-84% of salivary gland oncocytomas.2,3 Oncocytomas occurring in the submandibular gland and the minor salivary glands have been reported but are relatively uncommon. 2,7,9 CT is one of the established first-line imaging modalities used in the assessment of major salivary gland tumors. 2,17,18 To the authors' knowledge, there is limited description of the CT imaging features of parotid gland oncocytomas in the published literature, apart from a few case reports. 15,16,[19][20][21] Because the surgical resection of parotid tumors is generally the treatment of choice and allows histopathologic confirmation, the identification of specific CT imaging features suggestive of benign parotid oncocytomas will become helpful in terms of simply managing the patient expectantly when certain clinical scenarios arise-for example, if the patient declines surgical intervention, when patient factors such as age and multiple comorbidities preclude surgical resection, or when biopsy results are not diagnostic. In this study, we describe the CT features of 10 histopathologically proved cases of parotid oncocytomas, the largest imaging series in the published literature, to our knowledge. Materials and MethodsA review of parotid tumors that were discussed at combined clinicalradiologic-...

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Section: Discussionmentioning

confidence: 99%

CT Features of Parotid Gland Oncocytomas: A Study of 10 Cases and Literature Review

Tan¹,

Tan²

2010

AJNR Am J Neuroradiol

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“…Sugimoto et al [12] reported that oncocytomas commonly presented as a parotid mass with pain as well as with facial nerve paralysis, and that such symptoms were involved with 1/3 of the patients. However, our patient's main symptom was a slowly progressive painless mass and the facial paralysis, which occurred as a complication of surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Lungs, liver and brain metastasis have been reported. The long-term survival is poor because of distant disease, and long-term follow-up is necessary after therapy [12].…”

Section: Discussionmentioning

confidence: 99%

Oncocytic Carcinoma of the Parotid Gland

Çaloğlu¹,

Yurut-Caloglu²,

Altaner³

et al. 2006

Oncol Res Treat

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Background: Oncocytic carcinoma is a rare tumor of major salivary glands. Despite being described 5 decades ago, not much is known about these rare tumors. Histochemical or electron microscopic confirmation of the oncocytic nature of the tumor cell is needed for differential diagnosis. The main treatment modality is surgery with or without adjuvant radiotherapy. Malignant oncocytomas have the potential risk of developing distant metastases and demand long term follow-up after therapy. Case Report: A 58-year old man presented with a recurrent mass in the left parotid gland with a prior diagnosis of monomorphic adenoma in the same localization which had been treated by tumor excision in July 2002. Left superficial parotidectomy followed by radiotherapy into tumor bed and upper neck were carried out in September 2004. To date, he has had no evidence of recurrence for 14 months. Conclusion: For an accurate approach in the management of patients, oncocytic adenocarcinoma should be considered in the differential diagnosis of lesions of the parotid gland, most of which are benign.

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“…Tumoren mit einem Durchmesser kleiner 2 cm haben eine bessere Prognose [170]. Rezidive sollen in 25 ± 50 % der Fälle auftreten [55,349]. Es treten in 50 ± 60 % der Fälle neben Lymphknotenmetastasen auch hämatogene Fernmetastasen auf.…”

Section: Talgdrüsenkarzinomeunclassified

Ätiopathogenese und Histopathologie der Speicheldrüsenerkrankungen

Donath¹,

Ußmüller²

2001

Laryngorhinootologie

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Klinisch ist das Krankheitsbild durch eine schmerzhafte Schwellung mit tumorartiger Verhärtung des Drüsengewebes gekennzeichnet. Die entzündlichen Veränderungen verlaufen stadienhaft [307]. 3.4 Obstruktive Sialadenitis (Elektrolytsialadenitis) Die häufigste Speicheldrüsenentzündung ist mit 30 % die obstruktive Sialadenitis mit einem Altersgipfel in der 6. Lebensdekade und einer geringen Dominanz für das männliche Geschlecht [316, 318]. 3.5 Immunsialadenitis Bei der Immunsialadenitis liegt eine Störung des Immunsystems vor, die zu einer Speicheldrüsenentzündung führt.

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Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study

Cited by 35 publications

References 22 publications

CT Features of Parotid Gland Oncocytomas: A Study of 10 Cases and Literature Review

CT Features of Parotid Gland Oncocytomas: A Study of 10 Cases and Literature Review

Oncocytic Carcinoma of the Parotid Gland

Ätiopathogenese und Histopathologie der Speicheldrüsenerkrankungen

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