Malignant pericardial mesothelioma

Cao, Shoubo; Shi, Jin; Cao, Jingyan; Shen, Jing; Zhang, H.; Meng, Q.; Pan, Bo; Yu, Yan

doi:10.1007/s00059-016-4522-5

Cited by 30 publications

(26 citation statements)

References 64 publications

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“…Primary pericardial mesothelioma accounts for about 4% of the primary heart and pericardial tumors [ 1 ]. There is a slight male predominance with an average age at presentation of 46 years [ 2 ]. Unlike pleural mesothelioma, it has not been found to be associated with exposure to asbestos [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…The onset of symptoms is usually insidious. Clinical features are non-specific but commonly include pericardial syndromes, heart failure, and angina pectoris [ 2 ]. Echocardiographic findings are also non-specific.…”

Section: Discussionmentioning

confidence: 99%

“…Primary malignant pericardial mesothelioma (PPM) is an exceedingly rare neoplasm that accounts for about 4% of primary heart and pericardial tumors [ 1 ]. There are at present approximately 200 cases reported in the literature [ 2 ]. Because of its non-specific and insidious clinical presentation, a definitive diagnosis can be challenging and is often delayed [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are at present approximately 200 cases reported in the literature [ 2 ]. Because of its non-specific and insidious clinical presentation, a definitive diagnosis can be challenging and is often delayed [ 2 ]. Common clinical symptoms typically include heart failure, pericardial effusion, and angina pectoris [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Because of its non-specific and insidious clinical presentation, a definitive diagnosis can be challenging and is often delayed [ 2 ]. Common clinical symptoms typically include heart failure, pericardial effusion, and angina pectoris [ 2 ]. Non-invasive imaging modalities are useful to aid earlier diagnosis and guide biopsies [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Primary malignant pericardial mesothelioma: a case report

Farhat¹,

Salah²,

Milouchi³

2020

Pan Afr Med J

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Metastases to the heart and pericardium are much more common than primary malignant neoplasms. Primary malignant pericardial mesothelioma is a rare tumor that arises from the mesothelial cells of the pericardium. It is usually characterized by a delayed diagnosis, a low response to treatment, and a poor prognosis with an overall survival up to six months after the onset of symptoms. We report a rare case of a 32-year-old woman with primary pericardial malignant mesothelioma that was diagnosed 4 months after the onset of pericardial effusion as the first clinical manifestation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary malignant pericardial mesothelioma: a case report

Farhat¹,

Salah²,

Milouchi³

2020

Pan Afr Med J

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Localized primary malignant pericardial mesothelioma

Song

Zhang

et al. 2018

J of Clinical Ultrasound

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Primary malignant pericardial mesothelioma (PMPM) is an extremely rare tumor, which may appear as a localized or a diffuse mass encasing the heart. Diffuse PMPMs have a poor prognosis due to the difficulty of surgical excision, whereas localized PMPMs have clear margins, thus facilitating surgical excision. Timely diagnosis and proper treatment are crucial for a favorable prognosis. Eight cases of localized PMPMs have been reported so far, but their characteristics have not been fully described. Herein, we present a patient with localized PMPM and describe the diagnosis methods, treatment, and outcomes of these tumors. K E Y W O R D S echocardiography, pericardium, primary malignant mesothelioma

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A case of slowly progressive malignant pericardial mesothelioma suggesting the involvement of BAP1 loss

Fukasawa

Agemi

Shiba

et al. 2022

Respirology Case Reports

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Malignant pericardial mesothelioma (MPM) is a rare tumour that arises from the mesothelial cells of the pericardium. No standard treatment has been established owing to a poor treatment response; therefore, MPM has a poor prognosis. We herein report a rare case of MPM in a 70-year-old man that was diagnosed immunohistopathologically using cell block sections of pericardial fluid and in which longterm survival for more than 3 years was achieved with only periodic pericardial drainage. Immunohistopathological staining investigations, especially BRCA1-associated protein 1 (BAP1) immunostaining using cell block sections of pericardial effusion, are effective in making a diagnosis of MPM. Well-differentiated papillary mesothelioma (WDPM) with BAP1 loss progresses to MPM in the long term, showing that BAP1 loss may induce phenotypical evolution of WDPM. BAP1 loss may also progress to malignant mesothelioma in situ and then to invasive mesothelioma. BAP1 immunohistochemistry should be considered for the early diagnosis of MPM.

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Malignant pericardial mesothelioma

Abstract: Clinical trials of malignant pleural and peritoneal mesothelioma remain important for MPM management. Multimodality treatment of surgery, chemotherapy, radiotherapy, and immunotherapy is expected to have a role in the treatment of MPM.

Cited by 30 publications

References 64 publications

Primary malignant pericardial mesothelioma: a case report

Primary malignant pericardial mesothelioma: a case report

Localized primary malignant pericardial mesothelioma

A case of slowly progressive malignant pericardial mesothelioma suggesting the involvement of BAP1 loss

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