Malignant pericardial mesotheliomas and asbestos exposure: A case report

Beck, B; Konetzke, G; Ludwig, Volker; Röthig, W; Sturm, W

doi:10.1002/ajim.4700030205

Cited by 25 publications

(10 citation statements)

References 15 publications

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“…Thomason et al reported that exposure to asbestos had been documented in four of 28 cases (14%) 1) . Beck et al reported three cases of primary pericardial mesothelioma associated with occupational asbestos exposure 9) . In Japan, Kishimoto, et al reported a female case of pericardial mesothelioma who had been working in Navy dockyard, and found asbestos bodies in her lung 10) .…”

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confidence: 99%

An Autopsy Case of Primary Pericardial Mesothelioma in Arc Cutter Exposed to Asbestos through Talc Pencils

et al. 2005

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An autopsy case of a primary pericardial mesothelioma in a 53-year-old arc cutter is reported. He had often had the chance to inhale dust generated by sharpening the slate pencils composed of talc. He was admitted for heart failure due to pericardial tumor, but later died. The tumor was mainly located on the pericardium with a thickness of about 2.5 cm. Small nodular disseminations were observed in the left parietal pleura. Microscopically, tumor cells were epitheliallike and rich in histochemical demonstrable hyaluronic acid. Findings of immunohistochemical markers revealed keratin (+), EMA (+), calretinin (+), and CEA (-), which were characteristics of mesothelioma of epithelial type. The number of asbestos bodies (AB) in the lung parenchyma was increased (2,026 AB/gram dry lung tissue). Subsequent transmission electron microscopic examination equipped with an energy dispersive X-ray analyzer revealed that the fibers identified in the lungs were fibrous talc and actinolite. These findings suggested that this patient had been occupationally exposed to asbestos contaminated in the talc pencils, which induced the development of primary pericardial mesothelioma.Key words: Pericardial mesothelioma, Asbestos, Talc pencil, Fiber analysis Primary pericardial mesothelioma is an extremely rare and lethal cardiac tumor 1) . A correlation has been established between exposure to asbestos and the development of pleural and peritoneal mesothelioma in many epidemiological surveys 2) . However, the etiology of pericardial mesothelioma has not been elucidated. We report a case of pericardial mesothelioma occurring in an arc cutter who had used talc pencils, and examined the association between occupational exposure to asbestos and the development of this tumor by mineral analysis.A 53-years-old man was admitted to our hospital because of shortness of breath and leg edema. He had been working for an ironworks for 28 yr. He had used slate pencils composed of talc when he drew the lines of arc cutting on iron plates since he was 26 years-old. He had often inhaled the dust generated when sharpening the talc pencils using sandpaper without respirator. He had smoked 2 packs of cigarettes for 18 yr.Physical examination revealed distended jugular veins and leg edema. Breath sounds were decreased throughout the entire left lung field, but no fine crackle and no heart murmur was audible. His liver edge was palpable five fingerbreadths below the right costal margin.Chest radiography on admission revealed cardiac enlargement and bilateral pleural effusion (Fig. 1a). Computed tomographic scan of the chest revealed bilateral

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An Autopsy Case of Primary Pericardial Mesothelioma in Arc Cutter Exposed to Asbestos through Talc Pencils

et al. 2005

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“…In the present study, clinical and echocardiographic features of constrictive pericarditis were not present in any patient but in 45% of patients pericardial involvement in the form of pericardial thickening, pericardial effusion and pericardial calcification was detected. In the literature, more than 140 patients with primary malignant pericardial mesothelioma were reported 16,17 . However, in our clinic we have not seen any patient with primary malignant pericardial mesothelioma.…”

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confidence: 64%

“…In the literature, more than 140 patients with primary malignant pericardial mesothelioma were reported. 16,17 However, in our clinic we have not seen any patient with primary malignant pericardial mesothelioma.…”

Section: Discussionmentioning

confidence: 87%

Echocardiographic findings of pericardial involvement in patients with malignant pleural mesothelioma with a history of environmental exposure to asbestos and erionite

Özer¹,

Shehu

Aytemir³

et al. 2000

Respirology

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“…[36–10] The role of asbestos exposure is not clear, although it has been documented in a few patients. [3910] The clinical course of the disease is often rapid and the mean survival time from onset of symptoms to death is 5–8 months for the sarcomatous variant and 6–8 months for the biphasic variant. [4610] Cardiac tamponade is a well-known complication of the malignancy and often responds initially to pericardiocentesis or to pericardial window,[10] but some fatal cases have been reported.…”

Section: Discussionmentioning

confidence: 99%

Desmoplastic malignant mesothelioma of the pericardium: Description of a case and review of the literature

Nicolini¹,

Perazzo²,

Lanata³

2011

Lung India

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Desmoplastic mesothelioma (DMM) is a rare and highly lethal subtype of diffuse malignant mesothelioma and is often difficult to distinguish from reactive pleural fibrosis. The term “desmoplastic” refers to the growth of fibrous or connective tissue. We report the clinical, radiological, and pathological features of a primary DMM of the pericardium and a short review of the literature. A 72-year-old man was admitted presenting shortness of breath, cough, and asthenia. Computed tomography scan showed thickenings and effusions both in the pleura and in the pericardium. Histopathological diagnosis was performed by surgical pericardial biopsy and confirmed by autopsy. The patient had a history of asbestos exposure. Primary mesothelioma of the pericardium is a rare tumor occurring in the fourth to seventh decades with nonspecific symptoms and a rapid clinical course. The diagnosis is difficult and often needing a surgical pericardial biopsy. The prognosis is poor although newer antiblastic drugs seem to prolong survival times.

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Malignant pericardial mesotheliomas and asbestos exposure: A case report

Cited by 25 publications

References 15 publications

An Autopsy Case of Primary Pericardial Mesothelioma in Arc Cutter Exposed to Asbestos through Talc Pencils

An Autopsy Case of Primary Pericardial Mesothelioma in Arc Cutter Exposed to Asbestos through Talc Pencils

Echocardiographic findings of pericardial involvement in patients with malignant pleural mesothelioma with a history of environmental exposure to asbestos and erionite

Desmoplastic malignant mesothelioma of the pericardium: Description of a case and review of the literature

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