Malignant Peripheral Nerve Sheath Tumor of the Cerebellar Hemisphere: An Unusual Location and Multiple Intracranial Parenchyma Metastases

Ding, Jiangwei; Wang, Lei; Zhao, Haibiao; Wang, Feng; Sun, Tao

doi:10.7759/cureus.14373

Cited by 1 publication

(1 citation statement)

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“…21 For MPNST which develops within cranial nerves such as the vestibular nerve, uncontrolled growth may cause hearing loss and balance disorders. 22,23 In that case, when the surgery is not applicable due to the possibility of damaging important adjacent tissues, stereotactic radiosurgery is recommended. 24,25 This therapy involves the administration of one or several (<5 fractions) high doses of ionizing radiation (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), which often cause complications such as dizziness, damage to adjacent nerves, including the auditory nerve, or malignancy of the lesion.…”

Section: Introductionmentioning

confidence: 99%

High resolution optical spectroscopy for the evaluation of cannabidiol efficiency as a radiation therapy support of peripheral nervous system tumors

Chrabąszcz,

Pogoda,

Cieżak

et al. 2023

Preprint

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An increasing number of scientific papers discuss the promising therapeutic potential of cannabidiol (CBD) not only for the treatment of cancer, but also for asthma and neurodegenerative disorders. This happens mainly due to its proven anticancer, anti-inflammatory, and antioxidant properties. In the field of cancer research, the use of CBD has already been investigated on malignant tumors of the central nervous system, like gliomas. So far, CBD has not yet been explored in the therapy of peripheral nervous system (PNS) tumors. Peripheral nerves reside outside the central nervous system, therefore peripheral nerve tumors can occur anywhere in the body. When the tumor develops within large blood vessels, spinal nerves or involves more than one peripheral nerve, radiotherapy is recommended. Due to high doses of ionizing radiation, complications such as dizziness, damage to adjacent nerves, or malignancy of the lesion may occur. Therefore, it is important to develop a treatment scheme that efficiently reduces tumor volume while maintaining the normal functions of the surrounding cells and decrease the side effects. Herein, we proposed to combine hyperspectral imaging using Raman and FTIR spectroscopy and AFM-IR technique as a novel approach to monitor the therapeutic efficacy of CBD. Performed studies reviled the dual effect of CBD, that protects normal cells from ionizing radiation and increases its toxicity in cancer cells.

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Section: Introductionmentioning

confidence: 99%

High resolution optical spectroscopy for the evaluation of cannabidiol efficiency as a radiation therapy support of peripheral nervous system tumors

Chrabąszcz,

Pogoda,

Cieżak

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Malignant Peripheral Nerve Sheath Tumor of the Cerebellar Hemisphere: An Unusual Location and Multiple Intracranial Parenchyma Metastases

Abstract: Ding et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 1 publication

References 20 publications

High resolution optical spectroscopy for the evaluation of cannabidiol efficiency as a radiation therapy support of peripheral nervous system tumors

High resolution optical spectroscopy for the evaluation of cannabidiol efficiency as a radiation therapy support of peripheral nervous system tumors

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