Malignant peripheral nerve sheath tumor arising from solitary neurofibroma

Chung, Pei-I.; Chen, Changlin; Chang, Yun‐Ting; Liu, Han‐Nan

doi:10.1016/j.dsi.2013.10.001

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Significant morphologic overlap exists between monophasic SS and malignant peripheral nerve sheath tumor (MPNST): both are composed of fascicles of mitotically active spindle cells with scant amphophilic cytoplasm. However, MPNST typically arises from a pre‐existing neurofibroma or in the setting of neurofibromatosis type I 26 . A significant percentage of MPNST demonstrate positivity for SOX10, while SS is more commonly negative for SOX10.…”

Section: Discussionmentioning

confidence: 99%

Primary superficial synovial sarcoma: clinical and histopathological characteristics in eight cases with molecular confirmation

Laskin

Wang

et al. 2020

J Cutan Pathol

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Background and Aims Synovial sarcoma (SS) is a spindled cell sarcoma demonstrating varying degrees of epithelial differentiation and characterized by a pathognomonic t(X;18) translocation. SS most frequently involves deep soft tissue of the extremities in young adults. Superficial SS involving dermis and/or subcutaneous tissue is exceedingly rare. Methods and results We identified eight cases of primary superficial synovial sarcomas across three tertiary institutions. All cases were confined to the dermis/subcutis based on imaging or gross and microscopic examination. The average patient age was 36 years (range 14‐50). The average tumor size was 2.4 cm (range 0.9‐3.9 cm) and lesions showed classic monophasic (n = 4) or biphasic (n = 4) morphology. All tumors expressed keratin AE1/AE3 and/or epithelial membrane antigen (EMA), but were negative for CD34. The diagnosis for each case was confirmed by molecular detection of t(X;18). Six of the eight cases were treated with curative excision while the other two received additional radiotherapy. Follow‐up was available for six patients (mean 68 months, range 2‐108 months) and no patient experienced recurrence or metastatic disease. Conclusions We present the largest series to date of primary superficial SS with molecular confirmation for all cases. SS should be considered when evaluating a cutaneous monomorphic spindle cell neoplasm.

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Section: Discussionmentioning

confidence: 99%