Malignant Peripheral Nerve Sheath Tumors: Differentiation Patterns and Immunohistochemical Features - A Mini-Review and Our New Findings

Guo, Aitao; Liu, Aijun; Li-xin, Wei; Song, Xin

doi:10.7150/jca.4179

Cited by 71 publications

(83 citation statements)

References 29 publications

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“…In high grade tumour cells, S-100 is sparsely positive. Nestin, an intermediate filament protein is proven to be more sensitive than other neural markers in recent studies [6].…”

Section: Discussionmentioning

confidence: 99%

Malignant Peripheral Nerve Sheath Tumour of the Male Breast with Nodal Metastasis

Suganya

Ramakant

Palak

et al. 2015

Indian J Surg Oncol

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Malignant peripheral nerve sheath tumour (MPNST) is a rare soft tissue sarcoma with high rate of local recurrences and metastases. Common sites include deeper soft tissues, usually in the proximity of a nerve trunk. MPNST of breast is a rare occurrence. To our knowledge there are only less than 10 case reports of MPNST of breast. We present a young male patient with MPNST and lymph node metastases and also discuss diagnostic modes and management challenges in such rare difficult scenarios.

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“…In high grade tumour cells, S-100 is sparsely positive. Nestin, an intermediate filament protein is proven to be more sensitive than other neural markers in recent studies [6].…”

Section: Discussionmentioning

confidence: 99%

Malignant Peripheral Nerve Sheath Tumour of the Male Breast with Nodal Metastasis

Suganya

Ramakant

Palak

et al. 2015

Indian J Surg Oncol

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“…The heterogenous components include rhabdomyoblasts, cartilage, osseous, smooth muscle, glandular, neuroendocrine and liposarcomatous components. 53 It is rare to have more than two heterogenous component in a single MPNST, however, upto six differentiated components has been reported in a single tumor. 53 A careful interpretation of morphological findings and IHC findings is required in dedifferentiated MPNST to identify masked MPNST and to differentiate this tumor from various other tumors of heterogenous cell of origin (rhabdomyoblastTriton tumor, cartilaginous, osseous, smooth muscle, glandular, neurendocrine, gangliocytic, undifferentiated sarcoma).…”

Section: Malignant Peripheral Nerve Sheath Tumormentioning

confidence: 99%

“…53 It is rare to have more than two heterogenous component in a single MPNST, however, upto six differentiated components has been reported in a single tumor. 53 A careful interpretation of morphological findings and IHC findings is required in dedifferentiated MPNST to identify masked MPNST and to differentiate this tumor from various other tumors of heterogenous cell of origin (rhabdomyoblastTriton tumor, cartilaginous, osseous, smooth muscle, glandular, neurendocrine, gangliocytic, undifferentiated sarcoma). A distinction of dedifferentiated MPNST from dedifferentiated chondrosarcoma, dedifferentiated LPS, dedifferentiated rhabdomyosarcoma and dedifferentiated osteosarcoma is not an easy task.…”

Section: Malignant Peripheral Nerve Sheath Tumormentioning

confidence: 99%

“…A distinction of dedifferentiated MPNST from dedifferentiated chondrosarcoma, dedifferentiated LPS, dedifferentiated rhabdomyosarcoma and dedifferentiated osteosarcoma is not an easy task. 53 Dedifferentiated components of MPNST may pose differential diagnostic challenge to differentiate from metastatic carcinoma, synovial sarcoma and mesothelioma if the location of the tumor permits. An IHC marker in isolation is not diagnostic of MPNST.…”

Section: Malignant Peripheral Nerve Sheath Tumormentioning

confidence: 99%

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Tumor dedifferentiation: diagnostic and therapeutic implications

Jha

2017

J Pathol Nep

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Some of the neoplasm especially malignant tumors are notorious in masquerading their cell of origin because of additional mutations which drives them to differentiate into unusual phenotype. This is implicated to a phenomenon of tumor dedifferentiation which can mislead into inappropriate categorization and therapy. Dedifferentiation is well recognized in sarcomas such as liposarcoma, chondrosarcoma and MPNST. However, it can also develop in carcinomas, melanomas and lymphomas at initial diagnosis, following therapy or at recurrence. The phenomenon has been reported in both primary tumors as well as at metastatic foci. A correct and early pathological identification of this phenomenon might profoundly help in guiding appropriate therapy. Clinical and radiological findings, immunohistochemistry and genetic analysis are often required for correct lineage identification of these tumors.

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“…(Hendrick 1998, Koestner et al 1999, Stasik und Tawfik 2006, Dahme et al 2007, Guo et al 2012) bereits hinweisend auf das Vorliegen eines solchen, wobei die polygonalen Zellen als eher atypisch anzusehen sind. In der Humanmedizin bezeichnet man eine entsprechend auftretende Histomorphologie der Tumorzellpopulation als heterologe Differenzierung.…”

Section: Verlaufunclassified

“Triton tumor” in a Haflinger – case report, histology, therapy

Dressel¹,

Simon²,

Suchowski³

et al. 2017

PHK

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Schlüsselwörter: Pferd, Hauttumor, maligner Triton-Tumor, maligner peripherer Nervenscheidentumor, mPNST, Neurofibrosarkom, Fibropapillom, Onkologie "Triton tumor" in a Haflinger -case report, histology, therapy A 20-year-old Haflinger gelding was submitted with a history of neoplasms as big as a child's head located craniomedial at both thighs. Due to the morphology and predilection sites, initially there was the clinical suspicion of equine sarcoids. Because of advanced tumor growth the treatment consisted in surgical excision under general anesthesia. In the present case representative sites of neoplasia were embedded in paraplast and then asessed by light microscope at the H.-E.-stained cut. In the course of histological examination after routine processing multiple neoplasms composing the clinical visible proliferation medial on the right tight could be identified. In this patient, among other things, a tissue formation was diagnosed, whose histomorphology appeared similar to malignant Triton tumors in humans. These kind of neoplasia are very fast-growing, malignant nerve sheath tumors of peripheral nerves with rhabdomyoblastic differentiation. An immunohistological characterization was done to exclude other mesenchymal tumors (e.g. rhabdomyosarcoma or ulcerated equine sarcoid). The neoplastic cells were checked on a possible expression of S-100-protein, glial fibrillary acidic protein, (GFAP) and desmin. Both, the spindle and the rhabdomyoblastic tumor cells, showed an moderate to high-grade intracytoplasmic expression of S-100-protein. However, an expression of Desmin and GFAP could not be evidenced. The immunohistological result confirmed the suspected diagnosis of a malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. To the authors knowledge this is the first description of such a Triton tumor in the horse. So far, there is no data regarding the specific therapy and prognosis in this species. The treatment included surgical excision and subsequent adjuvant therapy with autogenous vaccines. In a period of two years no recurrence in the case has been observed.

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Malignant Peripheral Nerve Sheath Tumors: Differentiation Patterns and Immunohistochemical Features - A Mini-Review and Our New Findings

Cited by 71 publications

References 29 publications

Malignant Peripheral Nerve Sheath Tumour of the Male Breast with Nodal Metastasis

Malignant Peripheral Nerve Sheath Tumour of the Male Breast with Nodal Metastasis

Tumor dedifferentiation: diagnostic and therapeutic implications

“Triton tumor” in a Haflinger – case report, histology, therapy

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