Malignant Peritoneal Mesothelioma: Clinicopathological Characteristics of Two Cases

Abstract

Introduction. Peritoneal mesothelioma is a rare tumor, presenting difficulties in diagnosis and treatment. Peritoneum is the second most common area of the mesothelioma after pleura, and even synchronous pleural and peritoneal mesotheliomas are observed in 30–45% of all cases. The diagnosis may be difficult due to lack of specific symptoms and clinical findings. In addition, a delay in the diagnosis is not rare especially in the absence of previous asbestos exposure. Here we report two cases of malignant peritoneal mesotheliomas. The diagnostic and therapeutic approaches for these rare neoplasms are discussed. Case Presentation. The cases were two men (one aged 54 years old and the other 40 years old). Prolonged abdominal pain and swelling were the primary presentation symptoms and findings. The mesotheliomas were developed in the right upper quadrant of abdomen in both of the cases. Both cases were treated with surgical resection. Final diagnosis were possible with histological and immunohistochemical documentation of tumor characteristics, which were consistent with dictating a mesothelial origin. No history of asbestos exposure was reported. Conclusion. Peritoneal mesotheliomas are rare clinical entities. However, patients with prolonged abdominal pain and abdominal masses should be considered to have atypical pathologies such as peritoneal mesotheliomas.

Primary Peritoneal Mesothelioma Resulting in Small Bowel Obstruction: A Case Report and Review of Literature

“…The incidence rates range between 0.5 and 3 cases per million in men and between 0.2 and 2 cases per million in women in industrialized nations [ 2 ]. It has been previously determined that cumulative asbestos exposure leads to a proportional increase in mesothelioma risk [ 3 ]. Mesothelioma can result from non-industrial environmental contact with asbestos fibers, and para-occupational exposure occurs; for example, women who have laundered their husband’s work-related clothing [ 4 , 5 ].…”

“…Mesothelioma can result from non-industrial environmental contact with asbestos fibers, and para-occupational exposure occurs; for example, women who have laundered their husband’s work-related clothing [ 4 , 5 ]. However there are several non-asbestos etiologies that are carcinogenic, such as therapeutic irradiation, chronic inflammatory peritonitis, and simian virus-40 [ 1 , 3 ]. In particular, this report describes a 76-year-old woman who had a history of gynecological malignancy who received subsequent therapeutic chemoradiation and had extensive non-industrial exposure to asbestos.…”

Malignant Peritoneal Mesothelioma: A Rare Cause of Ascites

“…The incidence of MPM is one in a million, and in the United States, it accounts for 10% to 15% of all cases of mesothelioma. 1 , 2 There is a strong link between asbestos exposure and development of MPM, with approximately 50% of reported cases having asbestos exposure. The latency period between asbestos exposure and development of mesothelioma is approximately 40 to 45 years; thus, diagnosis can be challenging at the time of presentation.…”

“…The latency period between asbestos exposure and development of mesothelioma is approximately 40 to 45 years; thus, diagnosis can be challenging at the time of presentation. 2 This article reports an extremely rare case of MPM, epithelioid subtype, which was complicated by ascites.…”

Current approaches to treating patients with rare peritoneal tumors

“…В 1908 г. этот вид опухоли брюшины впервые был описан учеными Miller и Wynn. В общей структуре заболеваемости злокачественными новообразованиями данная патология составляет 0,16%, из них на мезотелиому брюшины приходится около 20% [1][2][3][4][5][6].…”