Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature

Kelten, Canan; Boyacı, Ceren; Leblebıcı, Cem; Behzatoğlu, Kemal; Trabulus, Didem Can; Sarı, Serkan; Nazli, Mehmet Ali; Bozkurt, Erol Rüştü

doi:10.1159/000448236

Cited by 6 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patients' age and gestational age at time of seeking medical attention, time from onset, past medical histories and family history of cancer, as well as side of tumor and the pathologic type related to malignancy of all included cases are demonstrated in Table 1. All tumors had first presented as a breast lump, except in three patients, 11,18,32 one bilateral and benign, 18 one malignant, 32 and one benign. 11 The first clinical picture in these three was breast enlargement.…”

Section: Data Extraction Resultsmentioning

confidence: 99%

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

et al. 2020

View full text Add to dashboard Cite

Background: Phyllodes tumor (PT) is a rare tumor of the breast, which may occur during pregnancy or lactation. Several studies have reviewed and discussed PT occurring in pregnancy, gathering up to 14 patients. We performed a thorough systematic review of the literature in an attempt to find all reported cases, and identify their common characteristics. Methods: We searched Google scholar, PubMed, Ovid Medline, Scopus and ClinicalTrials.gov with several relevant combinations of keywords, looking for texts or abstracts without any date or language limitations, but using only English keywords. The existing literature only consisted of case reports and series; therefore any paper including one or several cases of PT presenting during pregnancy or breastfeeding was recognized as eligible. Articles with vague description of the tumor which made the diagnosis uncertain, and those lacking data about the tumor and management data were excluded. We contacted authors for more details in cases with incomplete information. Results: After excluding those with very deficient data, we included 37 studies, counting 43 cases. The mean age of the patients was 31 years (21-43 years). Some features were different from usual PT: bilaterality (16.2%), large size (14.2 ± 8.6 cm), rapid enlargement (79.5%), and rate of malignancy (60.5%). Conclusion: Our findings show high rates of bilaterality, large size, rapid growth, and malignant pathology in the reported gestational PTs.

show abstract

Section: Data Extraction Resultsmentioning

confidence: 99%

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although mastectomy is likely to be recommended for some locally advanced tumors, breast-conserving surgery remains a good option for cases were surgical clear margins can be achieved. The vast majority of cases described conservative surgery as a first approach, but for most of the malignant cases, mastectomy was recommended in order to achieve clear margins as completion surgery [22][23][24][25]. Fatal outcome is uncommon for these diagnoses, since most of the tumors have a rapid growth pattern during pregnancy, and usually patients will approach a doctor sooner for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Malignant Phyllodes Tumor of the Breast and Pregnancy: A Rare Case Report and Literature Review

et al. 2021

View full text Add to dashboard Cite

Phyllodes Tumor (PT) is a rare fibroepithelial breast tumor that can behave differently depending on its biologic features. Traditionally, PTs are classified by their histologic features into benign, borderline, and malignant. In most cases that were reported, all PTs may recur, but only the borderline and malignant PT can metastasize. PT usually occurs as a breast lump or accidental finding on ultrasound (US) examination. The clinical features include a well-defined breast mass, regular or lobulated. The diagnosis is based on the integration of morphology features, but remains challenging, particularly in the distinction from fibroadenomas. We report a case of a 36-year-old patient who presented for a voluminous breast mass, rapidly growing in the past 3–4 months. At presentation, the patient was 19 weeks pregnant. The breast tumor had the clinical and US aspect of PT. A core needle biopsy was obtained, confirming a benign PT, and local excision was performed with no postoperative complications. The final pathology report showed a borderline PT with close resection margins of 1 mm. Immunohistochemistry (IHC) established the diagnosis of malignant PT with heterologous sarcomatous differentiation. The case was discussed in the multidisciplinary tumor board (MDT) and mastectomy was recommended. The patient fully consented but refused surgery at 25 weeks’ gestation, fearing premature delivery. The right breast was closely monitored by US, and at 9 weeks after the first surgery, signs of local recurrence were detected. At 35 weeks’ gestation, right mastectomy was performed, with no perioperative complications. The pregnancy was closely followed up and no complication were found. The final pathology report describes multiples PT recurrences with heterologous sarcomatous differentiation. The pregnancy outcome was uneventful, and the patient delivered a healthy child vaginally at term with no peripartum complication. Postpartum, a computer tomography (CT) examination of the head, thorax, abdomen and pelvis was performed, with no evidence of metastases. Adjuvant chemotherapy and radiotherapy completed the treatment. The follow-up and CT scan showed no metastases or further recurrence 4 years after diagnosis. In conclusion, diagnosis of PT can be difficult, especially because of the easy confusion with fibroadenoma of the breast. There are rare cases when a pathology exam needs further assessment and IHC is recommended for accurate diagnosis. Although malignant PT is rare and accounts for <1% of all breast cancers, the diagnosis and treatment that are recommended are based on the reported cases. Moreover, when complete surgical excision is achieved, the rates of recurrence and distant metastases are low, and adjuvant therapy might not be necessary.

show abstract

“…In the second trimester, the severity of the disease and the periods of the gestational week must be considered, then the pregnancy should be continued or terminated. In the third trimester, the gestational time should be appropriately extended to improve the survival probability of the fetus, and it is more common in premature babies [10]. In this case, considering the poor prognosis of the pregnant woman and the patient's expectation for the fetus, the fetal lung maturity was promoted and pregnancy was terminated as soon as possible when the survival probability of fetal survival was high.…”

Section: Treatmentmentioning

confidence: 99%

Case Report: Gastric Cancer Combined With Bilateral Ovarian Metastasis In Pregnancy

Zhen-hua¹,

Liu

Liu³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The early manifestations of gastric cancer during pregnancy are non-specific. Ovarian mass and ascites are the main manifestations of late ovarian metastasis. Case presentation: A case of late gastric cancer with bilateral ovarian metastasis in pregnancy was reported in our study. Cesarean section and full staging of ovarian malignant tumors were performed at 28+5 weeks of pregnancy, and the prognosis was poor. We performed Cesarean delivery and extracted a vital male newborn of 35 cm, 1020 g, Ap score 3. The newborn is alive and grows normally. Three months later the mother died. The key to improving the prognosis is early diagnosis, and the pre-pregnancy health checkup must be emphasized. Conclusions: During pregnancy, ultrasound, gastroscopy, MRI and other related examinations should be performed to confirm the diagnosis, and individualized treatment plans should be formulated to maximize the protection of the mother and child's interests.

show abstract

Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature

Cited by 6 publications

References 15 publications

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review

Malignant Phyllodes Tumor of the Breast and Pregnancy: A Rare Case Report and Literature Review

Case Report: Gastric Cancer Combined With Bilateral Ovarian Metastasis In Pregnancy

Contact Info

Product

Resources

About