Malignant phyllodes tumor of the breast with rapid progression: a case report

Abstract

Background Malignant phyllodes tumors (PTs) of the breast occur infrequently and are difficult to treat with adjuvant therapy. Here, we present a case of a female patient with a huge malignant PT with rapid progression in a short period. Case presentation A 44-year-old woman presented to our hospital with a rapid growth mass in her right breast, measuring 20 cm. She was initially diagnosed as having a borderline phyllodes tumor by core needle biopsy and underwent total mastectomy and artificial dermis was grafted, 20 days later, latissimus dorsi muscle flap and free skin grafting were performed. Two courses of doxorubicin–ifosfamide therapy were administered because of recurrence, but the patient died 4 months after the mastectomy. Conclusions A standard therapeutic strategy for malignant PTs is needed in urgently to reduce the risk of tumor recurrence.

Malignant Phyllodes Breast Tumor: A Rare Case of Metastasis in Skeletal Muscle Detected on 18-Fluorodeoxyglucose Positron Emission Tomography

“…Its distinguishing characteristic is rapid growth. PT usually affects middle-aged women, with a mean age of 45 years [ 2 ]. PT may contain foci of benign, borderline, and malignant features intermixed within the same neoplasm.…”

“…PT may contain foci of benign, borderline, and malignant features intermixed within the same neoplasm. A malignant component is differentiated from borderline tumors by marked stromal cellularity, stromal overgrowth, nuclear pleomorphism, and high mitotic activity [ 2 , 8 ].…”

“…Women in their fourth and fifth decades are commonly affected by this disease [1]. These can be benign, borderline, or malignant depending on histological characteristics, such as margin involvement, cellularity, mitosis, and cellular atypia [1,2]. Distant metastasis and recurrence are rare among benign and borderline cases; however, they are not uncommon in malignant PT and range from 25% to 40% [3][4][5].…”

Kiss Flaps to Repair Large Skin Defect After Excision of Giant Malignant Phyllodes Tumor of the Breast: A Case Report and Literature Review

“…Margin-negative resection combined with adjuvant radiotherapy is very effective for local control and prevention of recurrence [6]. Adjuvant chemotherapy is not the standard care since it is of controversial value for malignant phyllodes tumors, yet some institutions support doxorubicin-based adjuvant chemotherapy for rst-line treatment of breast sarcomas, especially with > 5.0 cm large high-risk tumors [22][23]. During postoperative follow-up, no local recurrence or distant metastasis were found.…”

Giant Borderline Phyllodes Tumor With Malignant Presentation: A Case Report

“…Phyllodes tumors (PTs) of the breast, also referred to as cystosarcoma phyllodes, adenomatous myxoma, and pseudosarcoma adenoma [1], are rare fibroepithelial tumors composed of epithelial and cellular stromal components [1,2]. PT accounts for less than 1% of all diagnosed breast neoplasms in the world [2].…”