Malignant pilomatricoma in a child with a previous vascular malformation

Zachariades, Nicholas; Mezitis, Michael; Rallis, George; Spyrou, Alexandra; Machera, Helen

doi:10.1016/j.bjoms.2007.01.013

Cited by 10 publications

(21 citation statements)

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“…Pilomatrix carcinomas have been further described as having enlarged epithelial cells, clusters of undifferentiated basaloid cells, invasion of adjacent blood vessels, and infiltration of capsular tissue [2,44]. In comparison with benign lesions, pilomatrix carcinomas most commonly affect middle-aged males, although a case of pilomatrix carcinoma in an 8-year-old girl has been reported [45][46][47]. This emphasizes the need for submission of these lesions for histopathologic examination and definitive diagnosis.…”

Section: Discussionmentioning

confidence: 94%

Characterizing pilomatricomas in children: a single institution experience

Hassan

Fallon

Schady

et al. 2013

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 94%

Characterizing pilomatricomas in children: a single institution experience

Hassan

Fallon

Schady

et al. 2013

Journal of Pediatric Surgery

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“…Thirty‐six patients underwent excision of a total of 35 solitary pilomatrix carcinomas and one solitary pilomatrical carcinosarcoma . There was a male predominance; 21 male patients (58%) compared to 15 female patients (42%) (male to female ratio of 1.4:1).…”

Section: Resultsmentioning

confidence: 99%

“…Information regarding initial clinical presentation was available for 22 patients . The commonest presentation was of an asymptomatic, firm, mobile nodule . Four patients presented with manifestations of locoregional disease or distant metastases, which included shoulder pain, dysphagia, severe back pain, bleeding and paraplegia .…”

Section: Resultsmentioning

confidence: 99%

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Pilomatrix carcinoma: 12‐year experience and review of the literature

Jones

Twoon

et al. 2017

J Cutan Pathol

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Pilomatrix carcinoma is a rare, locally aggressive tumor with a tendency to recur. Distant metastases have been reported, with pulmonary lesions being the most frequent manifestation. Similar to pilomatrixoma, pilomatrix carcinoma typically presents as a nontender, firm dermal swelling and is found most commonly in the head and neck region. Although pilomatrixomas and pilomatrix carcinoma are well-recognized lesions, clinically they are frequently misdiagnosed as other skin conditions. By reviewing the literature over the past 10 years, the aims of this review are to analyze the cause, clinical presentation, histopathologic features, management and outcomes of pilomatrix carcinoma amongst children and adults. Pilomatrix carcinoma is a rare, locally aggressive tumor with a tendency to recur. 6-8 Distant metastases have been reported, with pulmonary lesions being the most frequent manifestation. 7-10 Similar to pilomatrixoma, pilomatrix carcinoma typically presents as a nontender, firm dermal swelling [3][4][5][6]8,11 and is found most commonly in the head and neck region. 9,11In contrast to benign pilomatrixomas, which show a bimodal occurrence with a slight female predominance, 2,5 pilomatrix carcinoma commonly occurs in the 5th to the 7th decade with a male to female ratio of 4:1. 9,12Given its rarity, a gold standard treatment regimen has not been established, however, most studies recommend wide local excision with or without adjuvant radiotherapy.

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