Malignant Pleural Effusion: Presentation, Diagnosis, and Management

Gayen, S.

doi:10.1016/j.amjmed.2022.04.017

Cited by 58 publications

(48 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…She had Virchow’s nodes, which is the presence of left-sided supraclavicular lymphadenopathy, as the initial presentation of underlying gastric adenocarcinoma. The prognosis of malignant pleural effusion presentation is poor [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 15% of all cancer patients develop pleural effusion, with lung and breast cancer accounting for 50%-60%, followed by mesothelioma, lymphoma, and other hematologic malignancies [ 14 , 15 ]. SRCC more frequently metastasizes within the peritoneum, bone, and ovaries and less frequently to the lungs and liver than other adenocarcinomas [ 1 , 8 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Rare Case of Metastatic Gastric Signet Ring Cell Adenocarcinoma in a 23-Year-Old Female Presenting as Malignant Pleural Effusion

Torere¹,

Aiwuyo²,

Ilerhunmwuwa³

et al. 2022

Cureus

View full text Add to dashboard Cite

Signet ring cell carcinoma (SRCC) is a poorly differentiated mucin-producing adenocarcinoma with greater than 50% signet ring cells. It commonly arises from the gastrointestinal (GI) tract and rarely from extraintestinal organs. This is a rare case of a young African American female who presented with metastatic spread of signet ring cell gastric cancer (pleural and lymph nodal involvement) as the initial presentation of SRCC. Knowledge of the various clinical manifestations of SRCC can help with its early diagnosis, and there is a high need for detailed physical examination, early referral, and prompt treatment in patients with SRCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Rare Case of Metastatic Gastric Signet Ring Cell Adenocarcinoma in a 23-Year-Old Female Presenting as Malignant Pleural Effusion

Torere¹,

Aiwuyo²,

Ilerhunmwuwa³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Patients presenting with pleural effusion will require additional imaging for diagnosis and planning of therapeutic interventions. Bedside POCUS is increasingly being utilized for guidance for thoracentesis[ 37 ]. Pericardial effusions are noted in 5%-20% patients with an underlying malignancy and significantly impacts the survival and prognosis in these cases[ 38 , 39 ].…”

Section: Clinical Scenario 3: Effusionsmentioning

confidence: 99%

Point of care ultrasonography in onco-nephrology: A stride toward better physical examination

Bhasin¹,

Koratala²

2023

World J Nephrol

View full text Add to dashboard Cite

Onco-Nephrology is an emerging subspecialty of Nephrology that focuses on a broad spectrum of renal disorders that can arise in patients with cancer. It encompasses acute kidney injury (AKI), complex fluid, electrolyte, and acid-base disorders, as well as chronic kidney disease caused or exacerbated by cancer and/or its treatment. In many such scenarios including AKI and hyponatremia, objective evaluation of hemodynamics is vital for appropriate management. Point of care ultrasonography (POCUS) is a limited ultrasound exam performed at the bedside and interpreted by the treating physician intended to answer focused clinical questions and guide therapy. Compared to conventional physical examination, POCUS offers substantially higher diagnostic accuracy for various structural and hemodynamic derangements. In this narrative review, we provide an overview of the utility of POCUS enhanced physical examination for the Onconephrologist supported by the current evidence and our experience-based opinion.

show abstract

“…3,4 Early diagnosis of the nature of pleural effusion is critical for doctors and patients as it could affect both treatment options and patient outcomes. 5 The accuracy of traditional methods for diagnosing MPE varies widely. For instance, pleural effusion cytology was the simplest diagnostic method, with accuracy ranging widely from 62% to 90%.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of malignant pleural effusion with combinations of multiple tumor markers: A comparison study of five machine learning models

et al. 2023

View full text Add to dashboard Cite

Background To evaluate the diagnostic value of combinations of tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA153, and CA19-9 in identifying malignant pleural effusion (MPE) from non-malignant pleural effusion (non-MPE) using machine learning, and compare the performance of popular machine learning methods. Methods A total of 319 samples were collected from patients with pleural effusion in Beijing and Wuhan, China, from January 2018 to June 2020. Five machine learning methods including Logistic regression, extreme gradient boosting (XGBoost), Bayesian additive regression tree, random forest, and support vector machine were applied to evaluate the diagnostic performance. Sensitivity, specificity, Youden's index, and the area under the receiver operating characteristic curve (AUC) were used to evaluate the performance of different diagnostic models. Results For diagnostic models with a single tumor marker, the model using CEA, constructed by XGBoost, performed best (AUC = 0.895, sensitivity = 0.80), and the model with CA153, also by XGBoost, showed the largest specificity 0.98. Among all combinations of tumor markers, the combination of CEA and CA153 achieved the best performance (AUC = 0.921, sensitivity = 0.85) in identifying MPE under the diagnostic model constructed by XGBoost. Conclusions Diagnostic models for MPE with a combination of multiple tumor markers outperformed the models with a single tumor marker, particularly in sensitivity. Using machine learning methods, especially XGBoost, could comprehensively improve the diagnostic accuracy of MPE.

show abstract

Malignant Pleural Effusion: Presentation, Diagnosis, and Management

Cited by 58 publications

References 26 publications

A Rare Case of Metastatic Gastric Signet Ring Cell Adenocarcinoma in a 23-Year-Old Female Presenting as Malignant Pleural Effusion

A Rare Case of Metastatic Gastric Signet Ring Cell Adenocarcinoma in a 23-Year-Old Female Presenting as Malignant Pleural Effusion

Point of care ultrasonography in onco-nephrology: A stride toward better physical examination

Diagnosis of malignant pleural effusion with combinations of multiple tumor markers: A comparison study of five machine learning models

Contact Info

Product

Resources

About