Malignant pleural mesothelioma in US automotive mechanics: Reported vs expected number of cases from 1975 to 2007

Finley, Brent L.; Pierce, Jennifer S.; Paustenbach, Dennis J.; Scott, Laura; Lievense, Laura; Scott, Paul K.; Galbraith, David A.

doi:10.1016/j.yrtph.2012.05.015

Cited by 12 publications

(6 citation statements)

References 86 publications

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“…Therefore, there is no evidence that this patient’s malignant mesothelioma is due to occupational asbestos exposure. These results are consistent with previous studies demonstrating no increased risk of mesothelioma in mechanics and no evidence of elevated levels of asbestos in the lungs of these workers [6–13]. …”

Section: Discussion and Final Diagnosissupporting

confidence: 93%

“…These products contain chrysotile asbestos, which is less pathogenic than amphiboles. Furthermore, several epidemiological studies have shown that there is no increased occupational risk of mesothelioma in mechanics and other automobile workers who are regularly exposed to these products [6–13]. Indeed, in the current case, SEM analysis of lung tissue revealed no evidence of elevated asbestos fibers compared to control individuals with no history of asbestos exposure.…”

Section: Discussion and Final Diagnosismentioning

confidence: 48%

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Electron Microscopy Remains the Gold Standard for the Diagnosis of Epithelial Malignant Mesothelioma: A Case Study

Oczypok

Oury

2014

Ultrastructural Pathology

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This is a case of idiopathic epithelial malignant mesothelioma in a 47-year-old mechanic. The advent of a large battery of immunochemical markers has provided new tools for the diagnosis of mesothelioma in recent years, however, immunostaining can often be misleading or inconsistent, as demonstrated in the current case. This report highlights the lasting utility of electron microscopy in the diagnosis of mesothelioma. Ultrastructural features of epithelial mesothelioma were discernable using electron microscopy even on somewhat poorly preserved chest wall biopsy specimens from paraffin blocks. These images, combined with immunostains and a fiber analysis from the lungs, allowed for a final diagnosis of a non-asbestos related malignant epithelial mesothelioma in this patient.

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Section: Discussion and Final Diagnosissupporting

confidence: 93%

Section: Discussion and Final Diagnosismentioning

confidence: 48%

Electron Microscopy Remains the Gold Standard for the Diagnosis of Epithelial Malignant Mesothelioma: A Case Study

Oczypok

Oury

2014

Ultrastructural Pathology

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“…The lung burden among participants with MPM working in auto mechanics exposed to asbestos during brake repair, who exhibited the lowest fibre burden and the lowest percentage of amphibole fibres, is in line with the knowledge that chrysotile was the component of brakes and suggests caution on the opinion of absence of risk for MPM among auto mechanics 36 37…”

Section: Discussionsupporting

confidence: 69%

Residual fibre lung burden among patients with pleural mesothelioma who have been occupationally exposed to asbestos

Merler¹,

Somigliana²,

Girardi³

et al. 2016

Occup Environ Med

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“…Epidemiology studies of occupationally exposed cohorts are less easy to interpret, with some studies or analyzes concluding that automobile mechanics have an elevated risk. Nonetheless, other studies and meta-analyzes indicate that mesothelioma risks are not significantly elevated (Aguilar-Madrid et al, 2010;Butnor et al, 2003;Dotson, 2006;Finley et al, 2012;Garabrant et al, 2016;Goodman et al, 2004;Hessel et al, 2004;Laden et al, 2004;Paustenbach & White, 2012;Peto et al, 2009;Rake et al, 2009;Richter et al, 2009;Teschke et al, 1997;Wong 2001Wong , 2006. This certainly does not mean that the incremental risks are zero.…”

Section: Mesotheliomamentioning

confidence: 99%

Review of refractory ceramic fiber (RCF) toxicity, epidemiology and occupational exposure

Maxim¹,

Utell

2018

Inhalation Toxicology

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This literature review on refractory ceramic fibers (RCF) summarizes relevant information on manufacturing, processing, applications, occupational exposure, toxicology and epidemiology studies. Rodent toxicology studies conducted in the 1980s showed that RCF caused fibrosis, lung cancer and mesothelioma. Interpretation of these studies was difficult for various reasons (e.g. overload in chronic inhalation bioassays), but spurred the development of a comprehensive product stewardship program under EPA and later OSHA oversight. Epidemiology studies (both morbidity and mortality) were undertaken to learn more about possible health effects resulting from occupational exposure. No chronic animal bioassay studies on RCF have been conducted since the 1980s. The results of the ongoing epidemiology studies confirm that occupational exposure to RCF is associated with the development of pleural plaques and minor decrements in lung function, but no interstitial fibrosis or incremental lung cancer. Evidence supporting a finding that urinary tumors are associated with RCF exposure remains, but is weaker. One reported, but unconfirmed, mesothelioma was found in an individual with prior occupational asbestos exposure. An elevated SMR for leukemia was found, but was absent in the highly exposed group and has not been observed in studies of other mineral fibers. The industry will continue the product stewardship program including the mortality study.

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Malignant pleural mesothelioma in US automotive mechanics: Reported vs expected number of cases from 1975 to 2007

Cited by 12 publications

References 86 publications

Electron Microscopy Remains the Gold Standard for the Diagnosis of Epithelial Malignant Mesothelioma: A Case Study

Electron Microscopy Remains the Gold Standard for the Diagnosis of Epithelial Malignant Mesothelioma: A Case Study

Residual fibre lung burden among patients with pleural mesothelioma who have been occupationally exposed to asbestos

Review of refractory ceramic fiber (RCF) toxicity, epidemiology and occupational exposure

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