Malignant Priapism

Witters, S.; Cornelissen, M.; Vereecken, R.L.

doi:10.1159/000472557

Cited by 10 publications

(6 citation statements)

References 2 publications

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“… 8 , 10 An abnormal erection is reported in 20% to 53% of patients with metastatic penile cancer. 34 , 37 , 38 In these cases, histological examination shows metastatic cancer invading the vasculature, which explains the abnormal continuous erection and some investigators have called this condition “malignant abnormal erection.” 39 In patients with a history of cancer, metastatic penile cancer should be included in the differential diagnosis of a continuous painful erection after excluding the consequence of drugs, trauma, and hematological diseases.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Tumors of the Penis

Zhang¹,

Da²,

Yao³

et al. 2015

Medicine

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The purpose of this study was to report the clinical characteristics, treatments, and outcomes of secondary penile cancers and review the literature of this rare condition.The records of 8 patients with metastatic penile cancer treated at our hospital from 2006 to 2013 were analyzed. A search of medical databases was conducted.Patient symptoms included penile mass (n = 7, 5 had concomitant pain) and acute urine retention (n = 1). The primary cancers included bladder, lung, gastric, liver, and prostate malignancies and 1 case of pulmonary epithelioid hemangioendothelioma. The longest time from diagnosis of the primary cancer to metastatic penile cancer was 16 years and the shortest was 7 months. Six patients were treated with phallectomy, 1 with resection of the mass, and 1 with only a biopsy because of advanced metastatic disease. Five patients are deceased at the time of this report, and the longest and shortest survival times (from the diagnosis of primary cancer to the death) were 16 years and 9 months, respectively. The literature review identified 17 cases reported since 2011, bringing the total number of reported cases to 480. Genitourinary cancer, primarily bladder and prostate, account for approximately 70 of the primary cancer sites and gastrointestinal cancers account for approximately 21%. Approximately half of the patients had died of their disease within 1 year of the diagnosis of penile metastasis.The prognosis of metastatic penile cancer is poor. Most primary cancers are in the urologic or gastrointestinal systems. Surgery and adjunctive therapy may improve symptoms, but fail to prolong survival.

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Section: Discussionmentioning

confidence: 99%

Metastatic Tumors of the Penis

Zhang¹,

Da²,

Yao³

et al. 2015

Medicine

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“…About 40% of them are manifested with malignant priapism, a painful penile erection secondary to tumour metastasis. 1 Priapism occurs due to tumour infiltration of the corpora cavernosa and/or the venous drainage. 3 There are about 300 published cases of secondary penile malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3]9,16 More than 80% of patients die within 6 months, irrespective of the primary tumour and treatment. 16 However, in our case, the imaging studies did not show other metastases; therefore, we concluded that the penis was the isolated metastatic site.…”

Section: Discussionmentioning

confidence: 99%

“…M alignant priapism is prolonged penile erection without sexual stimuli, and is generally related to medical treatment, sickle cell disease, leukemia, polycythemia, penile metastasis of malignancies, pelvic thrombophlebitis and neurological diseases. [1][2][3] Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease. About 300 cases have been reported.…”

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Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma

Liu

Zeng

et al. 2014

CUAJ

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We report a case of isolated penile metastasis from renal pelvic carcinoma in a 69-year-old man with malignant priapism. The patient had radical resection of the renal pelvic carcinoma 2 months earlier with urothelial carcinoma (UC) and sarcomatoid differentiation histology. Physical examination showed no visible skin lesions, but a palpable hard nodule was present over the penile shaft. The imaging studies did not reveal other metastases. Cavernous-Glans shunt and nodule resection were performed, and histological examination showed metastasis UC with sarcomatoid differentiation. To our knowledge, we describe the first case of malignant priapism due to isolated penile metastasis of renal pelvic carcinoma. M alignant priapism is prolonged penile erection without sexual stimuli, and is generally related to medical treatment, sickle cell disease, leukemia, polycythemia, penile metastasis of malignancies, pelvic thrombophlebitis and neurological diseases. [1][2][3] Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease. About 300 cases have been reported. 4 Primary sites include the bladder (33%), prostate (30%), colon (17%) and kidney (7%). 5 Extra-pelvic sites, including the lung, pancreas, stomach, esophagus, melanoma and testis, have been noted. [6][7][8][9] Fewer than 20 cases of penile metastasis from renal cancer have been reported, most of them were renal cell carcinoma in origin. 10,11 On the other hand, penile metastasis has been a part of more widespread disease in about 90% of reported cases. 12 We describe a case of malignant priapism caused by penile metastasis of renal pelvic carcinoma in the absence of radiological disseminated disease. There have been no previous reports of renal pelvic carcinoma without regional metastasis with only penis metastasis. This is the first case of a renal pelvic carcinoma with isolated metastasis to penis. Case reportA 69-year-old male presented to our clinic with a 2-week history of malignant priapism. He had a radical resection of the renal pelvic carcinoma for right renal pelvic carcinoma at an outside centre 2 months previously ( Fig. 1) and the histopathology examination of the resected specimen revealed urothelial carcinoma (UC) and sarcomatoid differentiation (Fig. 2). All surgical margins and circum-renal lymph nodes removed during surgery were negative for tumour. The patient did not receive any kind of postoperative adjuvant therapy and was in a good general condition. On physical examination, the penis was tender, erect and consistency was wood-like, but the glans was flaccid. There was a palpable nodule in the corpora cavernosa of the penis, but no overlying skin necrosis of the glans. Corporal fine needle aspiration for blood-gas analysis failed to obtain any confirmatory sample. On digital rectal examination there was no suspicion of tumour involvement. Results of the laboratory evaluations were: white blood cell 9.52 × 109/L; red blood cell 3.78 × 1012/L; platelet 278 × 109/L; hemoglobin 1...

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“…Here, priapism was the first manifestation of malignancy in an otherwise asymptomatic patient. Priapism is a relatively common presentation of secondary penile cancer, occurring in about 40% of cases [8]. An aspiration of the corpora demonstrating only scant bleeding should alert the clinician, especially if there is a history of pelvic malignancy.…”

Section: Commentmentioning

confidence: 99%