Malignant primary brain and other central nervous system tumors diagnosed in Canada from 2009 to 2013

Abstract

BackgroundWe present a national surveillance report on malignant primary brain and other central nervous system (CNS) tumors diagnosed in the Canadian population in 2009–2013.MethodsPatients were identified through the Canadian Cancer Registry, an administrative dataset that includes cancer incidence data from all provinces/territories in Canada. Tumor types were classified by site and histology using the definitions from the Central Brain Tumor Registry of the United States (CBTRUS). Incidence rates (IRs) and 95% confidence intervals (CIs) were calculated per 100000 person-years (py) and age-standardized to the 2011 Canadian population for comparisons within Canada and to the 2000 United States population for comparisons with the US.ResultsOverall, 12515 malignant brain and other CNS tumors were diagnosed in the Canadian population in 2009–2013 (IR: 8.71/100000 py; 95% CI: 8.56, 8.86); 7085 were among males (IR: 10.06/100000 py; 95% CI: 9.82, 10.29) and 5430 among females (IR: 7.41/100000 py; 95% CI: 7.22, 7.61). Of these, 12115 were classifiable according to histological subgroups defined by CBTRUS. The most common histology was glioblastoma (IR: 4.06/100000 py; 95% CI: 3.95, 4.16). Among those aged 0–19 years, 1130 malignant brain and CNS tumors were diagnosed in 2009–2013 (IR: 3.36/100000 py; 95% CI: 3.16, 3.56). The most common histology among the pediatric population was embryonal tumor (IR: 0.74/100000 py; 95% CI: 0.65, 0.84).ConclusionsThese data represent an initial detailed report on the frequency and distribution of primary malignant brain and other CNS tumors diagnosed in the Canadian population in 2009–2013. The reported distributions of tumor diagnoses by sex and age reflected expected patterns based on the literature from similar populations. A report incorporating data on nonmalignant primary brain tumors is forthcoming.

Epidemiology of Anthropometric Factors in Glioblastoma Multiforme—Literature Review

“…Glioblastoma multiforme is a malignant primary tumor of the central nervous system. The incidence of GBM varies depending on the analyzed report, e.g., 3.20 [ 30 ], 4.06 [ 31 ], 4.17 [ 32 ], 4.40 [ 33 ], and 4.64 [ 34 ] per 100,000 inhabitants. GBM is therefore a rare disease.…”

“…Gittleman et al [ 33 ] described a statistically significant increase in the incidence of GBM in men, and according to Walker et al [ 31 ], it is unlikely that the continual predominance of men as patients with malignant histological types of glioma is accidental. Additionally, there are also studies that report the same gender distribution among GBM patients of different geographic origin [ 36 , 62 ].…”

State-of-the-Art CNN Optimizer for Brain Tumor Segmentation in Magnetic Resonance Images

“…LGG is a slow-spreading tumor, while HGG is a rapidly growing tumor, which explains why HGG is a fatal disease. People who are diagnosed with HGG and who are aged between 20-44 years have a survival rate of 19% with treatment after 14 months of diagnosis, based on a recent survey of the central nervous system (CNS) [1] on a Canadian population from 2009-2013. Figure 1 shows the distribution of survival rates between different types of brain tumors.…”

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“…Grade I tumors are slow-growing and are often found incidentally by CT or MRI [ 2 , 3 ]. The incidence of meningiomas increases with age, with the highest incidence in individuals age 80 or older [ 4 , 5 ].…”