Malignant-Primary (MAL-P) (Mesothelioma)

Michael, Claire; Hiroshima, Kenzo; Hjerpe, Anders; Michelow, Pam; Önal, Binnur; Segal, Amanda

doi:10.1007/978-3-030-53908-5_6

Cited by 8 publications

(11 citation statements)

References 71 publications

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“…10,23,28 Besides, for distinguishing between sarcomatoid lung carcinoma and sarcomatoid mesothelioma, GATA binding protein3 (GATA3) is recommended with its 100% sensitivity, usually being positive in the latter. 29 In the present ICC examination, 91.3% (735/805) of the ADC, 20.5% (15/73) of the SQC, about half (138/274) of all NSCC, and around one third (7/722) of all NET assays were CK7-positive (Table 2).…”

Section: Discussionmentioning

confidence: 48%

“…Most adenosquamous carcinomas, large cell carcinomas, and pleomorphic carcinomas as well as LCNEC are also said to express CK7 10,23,28 . Besides, for distinguishing between sarcomatoid lung carcinoma and sarcomatoid mesothelioma, GATA binding protein3 (GATA3) is recommended with its 100% sensitivity, usually being positive in the latter 29 …”

Section: Discussionmentioning

confidence: 99%

“…5,6,8,35 In order to compensate for the advantages and disadvantages of the individual antibodies, antibody combinations are used in practice. 10,29,36,37 The current WHO classification for lung tumours recommends the use of neuroendocrine markers only in the presence of neuroendocrine growth patterns (organoid cell nests, rosette-like structures, palisadelike patterns, etc.). In this analysis of 1960 tumours, only a small pro- In the literature only sufficiently large series have the necessary statistical power for assessing the differential diagnostic value of different antibody combinations.…”

Section: Discussionmentioning

confidence: 99%

“…It is very important to know the limitations of ICC for lung cancer subclassifications or rare tumour types such as LCNEC, basaloid squamous cell carcinoma, or NSCC with NET differentiation 5,6,8,35 . In order to compensate for the advantages and disadvantages of the individual antibodies, antibody combinations are used in practice 10,29,36,37 …”

Section: Discussionmentioning

confidence: 99%

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Recommendations for immunocytochemistry in lung cancer typing: An update on a resource‐efficient approach with large‐scale comparative Bayesian analysis

et al. 2021

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Objectives The majority of lung cancer cases are of advanced stage and diagnosis is usually made using minimally invasive small biopsies and cytological specimens. The WHO 2015 classification recommends limiting immunocytochemistry (ICC) to lung cancer typing and molecular testing drives for personalised therapies. An algorithm using Bayes' theorem could be useful for defining antibody profiles. This study aims to assess the impact of different antibody profiles for cytological samples on the accuracy of lung cancer typing with a large‐scale Bayesian analysis. Methods A retrospective examination of 3419 consecutive smears and/or cytospins diagnosed over 2011‐2016 found 1960 primary lung cancer tumours: 972 adenocarcinomas (ADC), 256 squamous carcinomas (SQC), 268 neuroendocrine tumours (NET), and 464 non‐small cell cancer‐not otherwise specified (NSCC‐NOS). The a priori and a posteriori probabilities, before and after ICC using antibodies singly or in combination, were calculated for different lung cancer types. Results TTF‐1 or CK7 alone improved the a posteriori probabilities of correct cytological typing for ADC to 86.5% and 95.8%, respectively. For SQC, using p40 (∆Np63) or CK5/6 together with CK5/14 led to comparable results (78.3% and 90.3%). With synaptophysin or CD56 alone, improvements in a posteriori probabilities to 87.5 and 90.3% for the correct recognition of NET could be achieved. Conclusions Based on morphological and clinical data, the use of two antibodies appears sufficient for reliable detection of the different lung cancer types. This applies to diagnoses that were finalised following ICC both on a clinical or cytological basis and on a histological basis.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Recommendations for immunocytochemistry in lung cancer typing: An update on a resource‐efficient approach with large‐scale comparative Bayesian analysis

et al. 2021

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“…Although ultrasonography in the chest is limited, it can be used for peripheral parenchymal, pleural, and chest wall diseases. Pleural thickening, pleural effusion, pneumothorax, pneumonia, or bronchopneumonia consolidations can be demonstrated by US (15,16). However, there is no specific US finding for the distinction between inflammation and malignancy in solid lesions.…”

Section: Discussionmentioning

confidence: 99%

Shear Wave Ultrasound Elastography and Diffusion-Weighted Magnetic Resonance Imaging Findings of Pleural-Based Masses with Histopathologic Correlation

Ünlü

Altınsoy

Balbay

et al. 2021

Konuralp Tıp Dergisi

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Objective: The study aims to evaluate the usefulness of non-invasive diagnostic methods, shear wave elastography (SWE), and diffusion-weighted magnetic resonance imaging (DWI) to differentiate benign and malignant lesions in the thoracic pleural based masses by comparing them with histopathological findings. Methods: Sixty-three patients having a pleural-based peripheral mass on computed tomography (CT), admitted to the interventional radiology department for transthoracic biopsy, were included in the study. All patients underwent DWI, and ADC values of the groups were measured. Transthoracic biopsy was performed with the guidance of US from the area where the highest shear wave velocity (SWV) value was calculated. ADC and SWV values of histopathologically proven benign and malignant lesions were statistically compared. Results: Fifty-six patients were male, and seven were female. The mean age was 64.68±10.13 years (41-85 years). Fourty-four patients were malignant, and 19 were benign. The maximum SWV was found to be 4.13±0.59 m/s in malignant cases and 3.55±0.71 m/s in benign cases, and the difference was significant (p = 0.001). Mean ADC value was measured as 1.04±0.30 x 10-3 mm2/s in malignant cases and 1.32±0.33 x 10-3 mm2/s in benign cases on DWI and the difference was significant (p = 0.002). In malignant cases, the minimum ADC was 0.73±0.29 x 10-3 mm2/s, and 0.99±0.44 x 10-3 mm2/s in benign cases, the difference was significant (p = 0.024). ROC analysis revealed a cut-off value of ≥4.08 m/s for SWVmax, ≤1.01x10-3 mm2/s for mean ADC, and ≤0.8x10-3 mm2/s for minimum ADC showed a significant performance in distinguishing malignant and benign lesions. Conclusions: Transthoracic US elastography and DWI are useful in differentiating malignant and benign lesions in appropriate cases. Both SWE and DWI are useful in routine use because they are non-invasive and do not contain radiation. In particular, SWE is suitable for biopsy guidance and may prevent the possibility of insufficient material.

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Metastatic upper tract urothelial carcinoma with nest‐like features presenting as malignant pleural effusion

Arienzo,

Valenti,

Ricci

et al. 2024

Diagnostic Cytopathology

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Metastatic urothelial carcinoma is a rare cause of pleural effusions. We report a case of urothelial carcinoma of the upper urinary tract in an oldest‐old male patient, a smoker, with situs inversus totalis, that presented uniquely with malignant pleural effusion at presentation without evidence of a primary tumor on imaging. Cytological smears of the massive left pleural effusion revealed epithelioid neoplastic cells arranged in short cords, small‐to‐large clusters, and raspberry‐like morules, mimicking mesothelioma; cell block preparations highlighted the presence of tubules and nest‐like structures. The tumor cells showed a high nuclear‐to‐cytoplasmic ratio, nuclear grooves, and mitotic figures. Cytomorphologic features coupled with the immunophenotype of neoplastic cells (p63, GATA3, and uroplakin II positive) allowed the diagnosis of metastatic urothelial carcinoma and a possible nested subtype. These findings were supported by a total body computed tomography (CT) showing no evidence of a mass in the bladder or elsewhere in the urinary tract but a concentric parietal thickening of the proximal left ureter, suggesting malignancy. To our knowledge, a malignant effusion as a primary manifestation of urothelial carcinoma with nest‐like features originating in the upper urinary tract has never been described previously. Our case focuses on the value of cell block in the working‐up of neoplastic effusions by revealing the architectural pattern of an uncommon malignancy and the correlation between cytopathology and imaging gross findings to reach an accurate diagnosis.

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Malignant-Primary (MAL-P) (Mesothelioma)

Cited by 8 publications

References 71 publications

Recommendations for immunocytochemistry in lung cancer typing: An update on a resource‐efficient approach with large‐scale comparative Bayesian analysis

Recommendations for immunocytochemistry in lung cancer typing: An update on a resource‐efficient approach with large‐scale comparative Bayesian analysis

Shear Wave Ultrasound Elastography and Diffusion-Weighted Magnetic Resonance Imaging Findings of Pleural-Based Masses with Histopathologic Correlation

Metastatic upper tract urothelial carcinoma with nest‐like features presenting as malignant pleural effusion

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