Malignant Primary Pulmonary Tumor with Hemangiopericytoma-Like Features: Conventional Hemangiopericytoma Versus Solitary Fibrous Tumor

Rădulescu, Dan; Pripon, Sorin; Ciuleanu, Tudor-Eliade; Radulescu, Letitia I.

doi:10.3816/clc.2007.n.037

Cited by 4 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the articles were not written in English. Radulescu et al ( 70 ) reported a case of malignant primary intrapulmonary SFT with haemangiopericytoma-like features.…”

Section: Discussionmentioning

confidence: 99%

Primary intrapulmonary solitary fibrous tumours

et al. 2018

View full text Add to dashboard Cite

Due to the extreme rarity of primary intrapulmonary solitary fibrous tumours (SFTs), their clinical course, imaging characteristics, diagnosis, treatment and prognosis are poorly understood. The present study therefore assessed the diagnosis and management of primary intrapulmonary SFTs and systematically reviewed previously reported cases in the literature. A total of 5 patients who underwent resection for primary intrapulmonary SFTs were enrolled in the present study and their clinical course, tumour characteristics, management and survival were assessed in this retrospective study. Relevant studies regarding primary intrapulmonary SFTs were searched using PubMed and tumour characteristics, clinicopathologic features, therapeutic strategy and survival outcomes were reviewed. Of the 5 cases, all were males, with a mean age of 57.6 years (range, 37–68 years). All patients were asymptomatic and were identified incidentally on routine computed tomography examination. A total of 3 patients underwent thoracotomy and 2 patients underwent video-assisted thoracoscopic surgery. All tumours were completely resected. Postoperative haemorrhage occurred in 1 patient and he received surgical intervention for haemostasis. The average hospital stay was 15 (4–22) days, and no mortality occurred. The mean length of the postoperative follow-up was 37.6 (1–67) months. One patient was lost to follow-up, and 4 patients were asymptomatic. A total of 19 studies were identified from database searches. They included a total of 45 patients: Twenty-three males and 22 females (mean age, 59.4 years; range, 7–81 years). A total of 12 patients were asymptomatic, and pain and coughing were the major symptoms. Five, one, two, four, and 17 tumours occurred in the right upper lobe, right middle lobe, right lower lobe, left upper lobe and left lower lobe, respectively. A total of 39 patients underwent surgery, 1 patient underwent radiotherapy, and 1 patient underwent radiofrequency ablation. A total of 22 patients were followed up and the mean length of the postoperative follow-up was 48 (1–168) months. One patient was diagnosed with chest wall metastases, and 5 patients succumbed to mortality. To conclude, primary intrapulmonary SFTs are extremely rare and typically identified incidentally. The present findings indicated that the left lower lobe was the most common site location and complete surgical resection is a safe and effective treatment.

show abstract

“…However, the articles were not written in English. Radulescu et al ( 70 ) reported a case of malignant primary intrapulmonary SFT with haemangiopericytoma-like features.…”

Section: Discussionmentioning

confidence: 99%

Primary intrapulmonary solitary fibrous tumours

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Haemangiopericytoma has been considered a controversial highly vascularized tumour. It was first described by Stout and Murray in 1942 as a neoplasm derived from the pericytes of Zimmerman, modified smooth muscle cells that regulate the calibre of the capillary lumen [ 4 , 5 ]. Since 2002 haemangiopericytomas have been reclassified as solitary fibrous tumour (SFT), since the term HPC gathers numerous non-related entities that share certain morphologic characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…The term haemangiopericytoma is nowadays used to describe a growth pattern rather than a clinical entity [ 5 ]. Histologically, HPC are sinusoidal vascular tumours with staghorn-shaped blood vessels surrounded by spindle shaped cells [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Immunochemistry has not met great success in the diagnosis of HPC, since cell markers present in normal pericytes, such as desmin and muscle actins, are not frequently found in HPC cells [ 4 ]. Moreover, they display several features of pericytic, fibroblastic and myofibroblastic differentiation, while they express CD34, CD99 and Bcl-2 antigens [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Soft tissue SFTs represent <2% of all soft tissue tumours; malignant HPCs represent <1% of all vascular tumours and around 5% of all sarcomatous tumours [ 2 , 5 , 6 ]. HPCs can more frequently be located at the lower extremities (34,9%), retroperitoneum and pelvic cavity (24,5%) [ 1 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Haemangiopericytoma of the greater omentum: a rare tumour requiring long-term follow-up

Vasdeki

Bompou

Anagnostou

et al. 2018

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Haemangiopericytomas (HPC) are highly vascularized tumours located in any part of the body where capillaries can be found. Since 2002, they have been re-classified under the umbrella ‘extrapleural Solitary Fibrous Tumour (SFT)’ and the term HPC is nowadays used to describe a growth pattern rather than a clinical entity. Their biological behaviour varies and they require a long-term follow-up since they may recur or metastasise several years after successful treatment. We present the case of a gentleman with HPC of the greater omentum initially appeared in 1998. HPC rarely develops in the greater omentum and only 20 cases have been described in the literature till today. Despite complete excision the mass re-appeared in 2011 and 2017, 13 and 19 years after initial treatment. Surgical management included en bloc excision of three lesions along with greater omentum. No further treatment was required.

show abstract

Malignant haemangiopericytomas of omentum presenting as left inguinal hernia: A case report

Shahid

Khan

Mehmood

et al. 2021

Annals of Medicine and Surgery

View full text Add to dashboard Cite

Background Hemangiopericytomas (HPC) are vascular tumors and can be found at any place where vessels are present. These were previously known as ‘extrapleural Solitary Fibrous Tumour’. These tumors may reoccur and metastasize after surgical excision. We present herein a HPC of the greater omentum, diagnosed as left inguinal hernia preoperatively. Case presentation A 61-year-old male, presented with a huge painless mass in his left inguinoscrotal region secondary to weigh-lifting associated with malaise and vague abdominal pain. A well-defined, non-tender, and firm mass was found at the left lower abdomen extending to the left inguinoscrotal region. Based on the examination, a diagnosis of indirect inguinal hernia was made. Abdominal ultrasound showed a heterogeneous, hyporeflective, and vascularized mass. Contrast-enhanced computed tomography scan identified a localized, extraperitoneal, heterogeneously hypodense, well-defined, and lobulated mass, with marked contrast enhancement. On exploration, an encapsulated large mass originating from the omentum with enormously dilated blood vessels was excised. On histopathology, a neoplastic lesion, composed of spindle-shaped cells and moderate cytoplasm was identified. The blood vessels appeared thin-walled with a staghorn appearance in hemangiopericytic pattern. Omental sections showed fibro adipose tissue with dilated lymphatics and thick-walled blood vessels. Features were consistent with a malignant HPC of 20 × 14 × 10 cm. Conclusion We present an unusual presentation of primary omental malignant HPC as an inguinal hernia, treated by complete surgical resection. These tumors are rare therefore, timely diagnosis is important for proper evaluation, diagnosis, and treatment. It also requires long-term follow up for better survival.

show abstract

Malignant Primary Pulmonary Tumor with Hemangiopericytoma-Like Features: Conventional Hemangiopericytoma Versus Solitary Fibrous Tumor

Cited by 4 publications

References 21 publications

Primary intrapulmonary solitary fibrous tumours

Primary intrapulmonary solitary fibrous tumours

Haemangiopericytoma of the greater omentum: a rare tumour requiring long-term follow-up

Malignant haemangiopericytomas of omentum presenting as left inguinal hernia: A case report

Contact Info

Product

Resources

About