Malignant proliferating trichilemmal tumour and CAV (cisplatin, adriamycin, vindesine) treatment

Hayashi, Io; Harada, Teruichi; Muraoka, Michinari; Ishii, Masamitsu

doi:10.1111/j.1365-2133.2004.05670.x

Cited by 28 publications

(30 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is no established chemotherapy regimen for metastatic TC reported in the medical literature. However, we found that Hayashi et al administered chemotherapy (cisplatin, adriamycin, vindesine: CAV treatment) similar to the regimen used for highly advanced cases of squamous cell carcinoma (9,13).…”

Section: Discussionmentioning

confidence: 70%

Recurrent and Metastatic Trichilemmal Carcinoma of the Skin Over the Thigh: A Case Report

Sym

Park

et al. 2010

Cancer Res Treat

View full text Add to dashboard Cite

I n t r o d u c t i o nTrichilemmal carcinoma (TC) is a rare malignant tumor that develops from the external root sheath of the hair follicle. It usually is found in the skin of the face or ears of elderly women on areas that are exposed to the sun, and TC generally has an indolent clinical course (1,2). This condition is usually curable after a wide excision (2). TC must be differentiated from other skin abnormalities such as squamous cell carcinoma, basal cell carcinoma, keratoacanthoma, and invasive Bowen's disease (3-5). TC is a low-grade carcinoma with a low metastatic potential (6). Surgical excision is considered to be the first choice for curative treatment (7,8), and no other reliable treatment strategies for TC have yet been established (9).We report here on a case of metastatic TC involving the skin over the thigh and this was treated with cisplatin and cyclophosphamide combination chemotherapy. C a s e R e p o r tA 63-year-old woman presented with a mass lesion in the left thigh in September 2006. The medical history and family history were unremarkable. The lesion was 5×5×4 cm in size, with irregular margins and superficial erosion. The entire lesion was removed by performing wide surgical excision and the resection margin was free of tumor. The final diagnosis was TC, and the tumor was composed of several epithelial aggregations arranged in various growth patterns, including solid, lobular and trabecular patterns (Fig. 1). In addition, the skin biopsy revealed that the specimen included neoplastic cells with abundant, clear cytoplasm, and the cells showed prominent atypia and high mitotic activity (Fig. 2).Two years later, the patient was hospitalized with swelling of the left lower leg and enlargement of the left inguinal lymph nodes. The blood pressure was 140/90 mmHg, the pulse rate was 78 bpm, the Trichilemmal carcinoma (TC) is an uncommon cutaneous neoplasm that develops from the external root sheath of the hair follicle. It is considered to be a low-grade carcinoma with low metastatic potential. Local recurrence and metastasis are rare after surgical excision. We report here on a case of metastatic TC in the skin over the thigh, and this tumor was treated with cisplatin and cyclophosphamide combination chemotherapy.

show abstract

Section: Discussionmentioning

confidence: 70%

Recurrent and Metastatic Trichilemmal Carcinoma of the Skin Over the Thigh: A Case Report

Sym

Park

et al. 2010

Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…Adjuvant chemotherapy is not thought to be superior to adequate surgery alone 22. The CAV regimen (cisplatin, adriamycin and vindesine) used for advanced SCC has shown only limited benefit 23. In addition, Takenaka et al report a case of MPTT resistant to radiotherapy, chemotherapy (cisplatin, bleomycin, adriamycin) and intralesional ethanol 24.…”

Section: Discussionmentioning

confidence: 99%

Malignant proliferating trichilemmal tumour

Singh¹,

Usman

Motta

et al. 2018

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…Anaplazi varlığı, yüksek mitoz oranı ve derin invazyon varlığı agresif karakteristikle ilişkili bulunmuş ve bu grupta nüks oranlarının daha yüksek olduğu bildirilmiştir. Özellikle nüks riskinin yüksek olduğu bu olgularda cerrahiye adjuvan olarak radyoterapi ve/veya kemoterapinin eklenmesi önerilmektedir (10) . Ender olmakla birlikte, lokal nüks ve uzak organ metastazı gelişen olgular da bildirilmiştir (1,3,4,(11)(12)(13)(14)(15) .…”

Section: Discussionunclassified