Malignant Renal Solitary Fibrous Tumor With Two Local Recurrences and Distant Pulmonary Metastasis

Sammoud, Skander; Ferjani, Souad; Hamdani, Moez; Toumi, A.

doi:10.1016/j.urology.2019.01.029

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…[27] Increasing number of studies suggest that radiation therapy may reduce local recurrence, but no increase overall survival time. [28,29] Based on the current study, combination therapy with bevacizumab and temozolomide was shown to be effective in the treatment of locally advanced SFT, temozolomide and dacarbazine can be active as single agents in SFT. [30,31] Additional clinical studies are needed to better characterize the molecular pathways involved with SFT in order to treat it more effectively.…”

Section: Discussionmentioning

confidence: 82%

A giant solitary fibrous tumor of the abdominal pelvic cavity: A case report and literature review

Li,

Yang,

Chen

et al. 2024

Medicine

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Rationale: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor, especially the giant one from the abdominal pelvic cavity. We report on a rare case of a giant SFT of the abdominal pelvic cavity to review the existing literature in detail to improve the diagnosis and treatment of SFT. Patient concerns: The patient is a 52-year-old female who presented with 2 weeks of abdominal distension. Abdominal magnetic resonance imaging showed a giant mass (>20 cm) in the abdominal pelvic cavity, considered a mesenchymal tumor. She denies a history of tumor disease. Diagnoses: A whole abdomen bulge and a mass of about 18 cm × 10 cm on the right side and middle side were found in the physical examination after admission. Abdominal enhanced computed tomography revealed a giant cystic-solid mass located on the middle and right side of the abdominal pelvic cavity, measuring approximately 20.4 cm × 11.7 cm, with multiple cystic changes and necrosis and compression of adjacent organs and tissues, and marked inhomogeneous enhancement. Interventions: The patient underwent an open abdominal pelvic cavity giant tumor operation to achieve a radical resection, and did not undergo chemotherapy or radiotherapy. Outcomes: The patient underwent open complete resection of a giant abdominal pelvic tumor with no complications and was diagnosed as SFT according to the pathology, immunohistochemistry showed that the tumor tested positive for CD34(+), STAT-6(+), and Ki-67 (10%). Abdominal computed tomography scans were performed 6 months after resection, and no signs of recurrence or metastasis were found. Lessons: The clinical symptoms and imaging features of giant abdominal pelvic cavity SFT are not typical. Preoperative diagnosis is difficult and has the potential for malignancy. Based on the results of the current study, there is no standard treatment strategy around the world and the therapeutic effect of radiation therapy and chemotherapy is relatively limited. Thus, complete surgical resection and close clinical follow-up are advocated.

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Section: Discussionmentioning

confidence: 82%

A giant solitary fibrous tumor of the abdominal pelvic cavity: A case report and literature review

Li,

Yang,

Chen

et al. 2024

Medicine

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“…Furthermore, an objective response has been reported in patients with recurrence and lung metastasis treated with doxorubicin and gemcitabine in combination. In this case, radiological follow-up showed PR [48]. In one of the analyses of advanced unresectable metastatic tumors or potentially resectable cases, patients received chemotherapy regimens based on doxorubicin or gemcitabine [186], but an objective response was not achieved.…”

Section: Treatment Of An Advanced and Metastatic Diseasementioning

confidence: 86%

“…A few studies showed that pelvic [27,30,41], abdominal [27,42], and pleural [27,40,43] SFTs tend to be larger than tumors appearing in other locations, and extrapleural SFTs may show potentially malignant behavior [44], especially those with limb localization [45]. Generally, over the years, SFTs have been described in various localizations, including the liver [46,47], kidney [48][49][50], pancreas [23,51,52], sigmoid colon [31], mesocolon [14], omentum [53,54], urinary bladder [55], caecum wall [56], mesorectum [41], prostate [57], spermatic cord [58], testis [59], scrotum [60], female gynecological tract, especially the vulva [61,62], vagina [63], breast [64][65][66], heart and pericardium [33,67,68], epicardium [69], pulmonary artery [70], trachea [71], larynx [32,72], tongue [15], salivary glands [73]<...…”

Section: Anatomical Locationmentioning

confidence: 99%

“…Moreover, most symptomatic cases present with pain [31,[98][99][100], and these tumors tend to be larger than asymptomatic ones [82]. Depending on the location, other manifestations include obstructive jaundice [52], a burning sensation during urination [14], urinary retention [57], abdominal discomfort [30], nausea, vomiting [48], hematochezia [31], hematuria [91], swelling [18], proptosis, blepharoptosis [18], dyspnea [33,69,98], sexual disorders, difficulty with defecation [91], coughing [98], and chronic bronchitis [33]. Furthermore, approximately 63% of SFTs located in the sinonasal tract present with nasal obstruction, and 87% of laryngeal tumors cause dysphonia [101].…”

Section: Diagnosismentioning

confidence: 99%

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Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Janik,

Terlecka,

Spałek

et al. 2023

Cancers

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Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms that account for less than 2% of all soft tissue masses. In the latest WHO 2020 Classification of Soft Tissue Tumors, extrameningeal SFT was listed as intermediate (rarely metastasizing) or malignant neoplasms. Due to the lack of characteristic clinical features, their diagnosis and treatment remain challenging. The pathogenesis of SFT is often associated with the presence of fusions of the NAB2-STAT6 gene on the 12q13 chromosome. Cytoplasmic CD34 positive staining is considerably characteristic for most SFTs; less frequently, factor XII, vimentin, bcl-2, and CD99 are present. A key factor in the diagnosis is the prevalent nuclear location of STAT6 expression. Radical resection is the mainstay of localized SFTs. In the case of unresectable disease, only radiotherapy or radio-chemotherapy may significantly ensure long-term local control of primary and metastatic lesions. To date, no practical guidelines have been published for the treatment of advanced or metastatic disease. Classical anthracycline-based chemotherapy is applicable. The latest studies suggest that antiangiogenic therapies should be considered after first-line treatment. Other drugs, such as imatinib, figitumumab, axitinib, and eribulin, are also being tested. Definitive radiotherapy appears to be a promising therapeutic modality. Since standards for the treatment of advanced and metastatic diseases are not available, further investigation of novel agents is necessary.

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Malignant Renal Solitary Fibrous Tumor With Two Local Recurrences and Distant Pulmonary Metastasis

Cited by 2 publications

References 16 publications

A giant solitary fibrous tumor of the abdominal pelvic cavity: A case report and literature review

A giant solitary fibrous tumor of the abdominal pelvic cavity: A case report and literature review

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

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