Malignant rhabdoid tumor of the central nervous system with subarachnoid dissemination

Agranovich, Alexander; Ang, L. C.; Griebel, Robert; Kobrinsky, Nathan L.; Lowry, Noel J.; Tchang, S

doi:10.1016/0090-3019(92)90014-e

Cited by 48 publications

(35 citation statements)

References 7 publications

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“…Results of the immunohistochemical studies show positivities for three antibodies whose epitopes are almost always expressed: EMA, vimentin, and smooth-muscle actin (SMA) (3,4,6,7,10). These positivities are not found in PNETMBs: in particular, EMA is always negative in PNET-MBs (10).…”

Section: A B C Dmentioning

confidence: 93%

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Primary Intracranial Atypical Teratoid/Rhabdoid Tumor in a Child: A Case Report

et al. 2002

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Rhabdoid tumors of the central nervous system are rare malignancies. Primary central nervous system atypical teratoid/rhabdoid tumors (ATT/RhTs) mostly occur during early childhood and are almost invariably fatal. These tumors show similar histological and radiological features to primitive neuroectodermal tumor-medulloblastoma (PNET-MB) but have different biological behaviors. We report a case of primary intracranial ATT/RhT in the posterior cranial fossa of a child. Preoperative radiological diagnosis was PNET-MB, but pathological diagnosis is ATT/ RhT. The case involved a 16-month-old baby boy who presented with severe headache, vomiting, and gait disturbance. He was treated by surgical resection, chemotherapy, and radiotherapy. Despite aggressive therapy, he died 19 months after diagnosis. Clinical, radiological, and histopathological features of primary intracranial ATT/RhT are discussed with a special emphasis on the differential diagnosis from PNET-MB.

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Section: A B C Dmentioning

confidence: 93%

“…These positivities are not found in PNETMBs: in particular, EMA is always negative in PNET-MBs (10). Results for GFAP, germ cell tumor markers, desmin, neurofilament, and myoglobulin are negative (2, 4-6, 10).…”

Section: A B C Dmentioning

confidence: 94%

Primary Intracranial Atypical Teratoid/Rhabdoid Tumor in a Child: A Case Report

et al. 2002

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“…All studies published as of today show that teratoid/rhabdoid tumors are highly malignant and almost invariably fatal neoplasms seen in infancy and early childhood, usually occurring in the posterior fossa [2,3,4, 6, 7, 9, 10, 12]. Time of diagnosis, location of the tumor and outcome of the patient vary greatly in review of former and present literature.…”

Section: Discussionmentioning

confidence: 99%

“…An atypical teratoid/rhabdoid tumor is a rare malignant and aggressive tumor of the central nervous system, usually occurring during early childhood but very rarely in adults [2, 4, 6,8,9,10]. …”

Section: Discussionmentioning

confidence: 99%

Giant Supratentorial Atypical Teratoid/Rhabdoid Tumor Presentation: A Case of a Five-Year-Old Child with Favorable Outcome and Review of the Literature

Sasani¹,

Öktenoğlu²,

Ozer³

et al. 2007

Pediatr Neurosurg

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Atypical teratoid/rhabdoid tumor of the central nervous system is a highly malignant neoplasm and that usually arises in the posterior fossa, survival from this is frequently poor. We present a unique case in a 21-month-old girl who had an atypical teratoid/rhabdoid tumor with cystic components located in the right fronto-parietal lobe. The patient underwent radical surgical intervention followed by chemotherapy. It consisted of five chemotherapeutic agents, but the patient did not receive any radiotherapy. The postoperative course was uneventful and the patient was followed-up by cranial magnetic resonance imaging every 3 months. Two years later at the last follow-up visit, there was no evidence of a tumor relapse on MRI, and the examination was symptom free. It is possible the favorable outcome of the patient resulted from a rapid diagnosis, prompt management, radical surgical intervention and aggressive chemotherapy.

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“…Primary carcinomas with rhabdoid features have been reported in various anatomical sites including the bladder, 3,4 the prostate, 5 the liver, 6,7 the uterus, [8][9][10][11] the central nervous system [12][13][14][15][16] and the vulva. 17,18 In the kidney, pure rhabdoid carcinomas are usually found in the pediatric population, in which they account for 2% of pediatric renal tumours.…”

Section: Discussionmentioning

confidence: 99%

Treatment of adult rhabdoid renal cell carcinoma with sorafenib

Kapoor

Tutino

Kanaroglou

et al. 2008

CUAJ

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631operating room notes, pathological records and other relevant documents were used as a resource to compile information on this case. We also included recent assessments of the patient in this report. A literature review was conducted using a search of EMBASE, MEDLINE/PubMed and the Cochrane Database. We used the search terms "rhabdoid," "renal cell carcinoma," "adult" and "tumor." References of articles found were also searched for relevant articles. CaseA 47-year-old woman presented to her family physician with a 3-month history of leftsided flank pain and nausea. On physical examination a hard palpable mass was found in her abdomen. Her past medical history included hypertension, migraine headaches, anemia and a previous right inguinal hernia. She had no family history of urological malignancies, but had a paternal cousin with colon cancer and paternal uncle with lung cancer. The patient was a lifelong nonsmoker.Ultrasonography of her abdomen revealed a complex hypervascular mass in the upper pole of her left kidney measuring 11.1 × 11.8 × 7.5 cm. The mass enlarged the left kidney to 16.0 cm in length. The right kidney appeared to be healthy. A contrast-enhanced computed tomograpy scan showed a hypervascular tumour in her left kidney infiltrating the left psoas and spleen, with evidence of retroperitoneal lymphadenopathy and tumour thrombus extending to the infrahepatic vena cava. Lesions highly suspected as metastastic deposits were found in the liver. A chest radiograph showed multiple nodules in both lung fields, also suggestive of metastatic disease. A bone scan revealed an ill-defined area in the left sixth rib and abnormal uptake in both distal femurs, consistent with metastasis to these sites. Treatment of adult rhabdoid renal cell carcinoma with sorafenib CASE REPORT AbstractRenal cell carcinoma (RCC) with rhabdoid features is an uncommon and highly aggressive malignancy. We report a case of adult clear-cell RCC with extensive rhabdoid features treated with the tyrosine kinase inhibitor sorafenib. A review of the literature summarizes important aspects of this malignancy. We discuss clinical and histological findings as well as the patient's response to sorafenib therapy.

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Malignant rhabdoid tumor of the central nervous system with subarachnoid dissemination

Cited by 48 publications

References 7 publications

Primary Intracranial Atypical Teratoid/Rhabdoid Tumor in a Child: A Case Report

Primary Intracranial Atypical Teratoid/Rhabdoid Tumor in a Child: A Case Report

Giant Supratentorial Atypical Teratoid/Rhabdoid Tumor Presentation: A Case of a Five-Year-Old Child with Favorable Outcome and Review of the Literature

Treatment of adult rhabdoid renal cell carcinoma with sorafenib

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