Malignant Seminoma in Two Unilaterally Cryptorchid Stallions

Lange, Valérie De; Chiers, Koen; Lefère, Laurence; Cools, Marc; Ververs, Cyrillus; Govaere, Jan

doi:10.1111/rda.12488

Cited by 12 publications

(16 citation statements)

References 18 publications

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“…In stallion 11, an observed increase in T concentrations after hCG administration indicated the presence of testes [ 14 , 15 ]; thus, stallion 11 was diagnosed as having cryptorchid testes and was determined to not have been castrated. Stallion 11 was castrated using laparoscopy to prevent cryptorchidism from developing into tumors [ 29 , 30 ]. Both testes were found in the abdominal cavity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the chemiluminescent enzyme immunoassay system for the measurement of testosterone in the serum and whole blood of stallions

Toishi

Tsunoda²,

Nagata

et al. 2018

Journal of Reproduction and Development

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Testosterone (T) concentration is a useful indicator of reproductive function in male animals. However, T concentration is not usually measured in veterinary clinics, partly due to the unavailability of reliable and rapid assays for animal samples. In this study, a rapid chemiluminescent enzyme immunoassay system (CLEIA system) that was developed for the measurement of T concentration in humans use was validated for stallion blood samples. First, serum T concentrations were measured using the CLEIA system and compared with those measured by a fluoroimmunoassay that has been validated for use in stallions. The serum T concentrations measured by the two methods were highly correlated (r = 0.9865, n = 56). Second, to validate the use of whole blood as assay samples, T concentrations in whole blood and in the serum were measured by the CLEIA system. T concentrations in both samples were highly correlated (r = 0.9665, n = 64). Finally, to evaluate the practical value of the CLEIA system in clinical settings, T concentrations were measured in three stallions with reproductive abnormalities after the administration of human chorionic gonadotropin (hCG). Two stallions with small or absent testes in the scrotum showed an increase in T production in response to hCG administration and one stallion with seminoma did not. In conclusion, the CLEIA system was found to be a rapid and reliable tool for measuring T concentrations in stallions and may improve reproductive management in clinical settings and in breeding studs.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the chemiluminescent enzyme immunoassay system for the measurement of testosterone in the serum and whole blood of stallions

Toishi

Tsunoda²,

Nagata

et al. 2018

Journal of Reproduction and Development

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“…12 Common sequelae to cryptorchidism in all species is infertility 18 and neoplasia. 15,16,[19][20][21][22][23] However, neoplasia was not identified in the pigs of the present report because of their relatively young age.…”

Section: Commentsmentioning

confidence: 99%

“…Although undescended testes are more prone to develop neoplasia than are scrotally located testes, neoplasia was not evident in either affected pig of the present report, most likely due to the age of the animals. 2 Cryptorchidism has been documented in different species including humans, [4][5][6][7][8][9][10][11] dogs, 12 rats, 13 mice, 14 and horses 15 as well as domestic and exotic cats. 16,17 In humans, the condition has been associated with genetics, environmental exposure to contaminants (eg, maternal smoking or maternal radiation during pregnancy), the use of analgesic drugs by the mother during pregnancy, and premature birth.…”

Section: Commentsmentioning

confidence: 99%

Pathology in Practice

Gades

Moe

Waldron

et al. 2021

javma

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“…Although the literature includes many cases of seminoma affecting cryptorchid horses [ 9 , 10 , 11 , 12 ], the neoplasm can also affect descended testes [ 7 , 8 , 13 , 14 , 15 ]; in human medicine, cryptorchidism is found to increase chances of developing seminoma [ 3 ]. Indeed, a correlation between cryptorchidism and the onset of neoplasia has not been proven for horses [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to other species, equine seminomas are frequently malignant, metastasizing to the abdominal organs, including the liver [ 9 , 16 ] and kidney [ 12 ], lymph nodes [ 9 ], peritoneum, mesentery and ureter, and also to the mediastinum [ 9 , 11 , 13 ]; nevertheless, clinical signs are mild and frequently nonspecific, such as weight loss [ 12 ] and nonsymmetrical testicular size [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Examination of Unilateral Seminoma in a Salernitano Stallion

Giangaspero

Bucci

Signore

et al. 2022

Animals

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An 18-year-old Salernitano stallion developed a progressive enlargement of the left testicle over eight months. An ultrasound evaluation was performed, along with a hormonal profile. A histopathological evaluation of the testis was performed after unilateral orchiectomy. On B-mode ultrasound examination, testicular parenchyma was characterized by the loss of internal structure, with the presence of multiple coalescing, nodular, well-defined and heterogeneous lesions with capsule deformity, appearing with an irregular profile. On dissection, the testicular parenchyma bulged over the cut section, confirming the increase in size. Microscopically, the lesion consisted mainly of large, densely packed, polygonal-to-round-shaped neoplastic cells. Mitotic figures were plentiful and frequently atypical; further microscopic features included apoptosis and necrosis. At immunohistochemistry, the entire neoplasm showed strong and diffuse immunolabeling for vimentin, while CD117-specific immunoreactivity was only observed in scattered clusters of neoplastic cells. Based on the gross, microscopic and IHC findings, a diagnosis of diffuse seminoma was made. Three months later, a follow-up examination showed no evidence of recurrence and the preservation of reproductive abilities. The case presented shows an unusual ultrasonographic pattern for seminoma and the basis of the correlation between the characteristics of the sonoelastographic examination and histological diagnosis.

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Malignant Seminoma in Two Unilaterally Cryptorchid Stallions

Cited by 12 publications

References 18 publications

Evaluation of the chemiluminescent enzyme immunoassay system for the measurement of testosterone in the serum and whole blood of stallions

Evaluation of the chemiluminescent enzyme immunoassay system for the measurement of testosterone in the serum and whole blood of stallions

Pathology in Practice

Ultrasound Examination of Unilateral Seminoma in a Salernitano Stallion

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