Malignant Skin Tumors Among Dermatology Patients in University Hospitals of Japan

Tada, Masahiro; Miki, Yoshiharu

doi:10.1111/j.1346-8138.1984.tb01484.x

Cited by 45 publications

(7 citation statements)

References 5 publications

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“…6,71 The incidences of BCC per 100,000 population have been reported in different races as follows: black men (1), black women (2) 2,7,17,19,34,51,74,75 The incidence of BCC in Caucasians in Kauai, Hawaii, is reported to be the highest in the United States. 34 The ratio of BCC to SCC in Japan in the 1960s was 1e1.4:1, 76 whereas in the 1990s the ratio increased to 4.5:1, 54 suggesting an increasing trend of BCC in Japan. The incidence of BCC among Asian residents of Singapore increased at a rate of 2% to 8% annually from 1968 to 1997.…”

Section: Bccmentioning

confidence: 96%

Skin cancer in skin of color

Gloster

Neal

2006

Journal of the American Academy of Dermatology

587

474

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Section: Bccmentioning

confidence: 96%

Skin cancer in skin of color

Gloster

Neal

2006

Journal of the American Academy of Dermatology

587

474

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“…The fact that "the nearer people live to the equator, the higher the frequencies of skin cancers" is true even among people of the same race (85). Skin cancers can be induced by irradiating mice with UV-B (14,62).…”

Section: Roles Of Ros In Uv Carcinogenesismentioning

confidence: 99%

Role of Reactive Oxygen Species in Skin Carcinogenesis

Nishigori

Hattori²,

Toyokuni³

2004

Antioxidants & Redox Signaling

243

174

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Reactive oxygen species (ROS) are associated not only with initiation, but also with promotion and progression in the multistage carcinogenesis model. In the present review, we will focus on the involvement of ROS in skin carcinogenesis, especially that induced by ultraviolet (UV) radiation. UV-specific DNA damage has been well studied thus far. However, recent reports have revealed the previously unknown participation of oxidative stress in UV-induced skin carcinogenesis. Indeed, in addition to transition-type mutations at dipyrimidine sites, G:C to T:A transversions, which may be induced by the presence of 8-oxoguanine during DNA replication, are frequently observed in the ras oncogene and p53 tumor suppressor gene in human skin cancers of sun-exposed areas and in UV-induced mouse skin cancers. Recent studies have shown that not only UV-B, but also UV-A is involved in UV-induced carcinogenesis. A wide variety of biological phenomena other than direct influence by UV, such as inflammatory and immunological responses and oxidative modifications of DNA and proteins, appear to play roles in UV-induced skin carcinogenesis. Furthermore, it has become clear that genetic diseases such as xeroderma pigmentosum show deficient repair of oxidatively modified DNA lesions. The involvement of ROS in skin carcinogeneisis caused by arsenic and chemical carcinogens will also be discussed.

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“…The incidence of skin cancer in the Japanese population is estimated to be much lower than that in western populations. 9,10 Skin cancer has a relatively large proportion of LM after HSCT 3-5 and actually skin cancers were included in the above two reports (5 out of 12 in Burroughs et al 8 and at least 2 out of 11 in Ades et al 6 ). In contrast, no skin cancer was observed in our series.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan

Kikuchi

Yabe

Katô³

et al. 2012

Bone Marrow Transplant

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We report long-term outcomes of 329 childhood severe aplastic anemia (SAA) patients who underwent hematopoietic SCT (HSCT) from an HLA-matched sibling donor in the Japanese Hematopoietic Cell Transplantation Registry. OS and EFS at 10 years were as high as 89.7 þ / À 1.7% and 85.5 þ / À 2.0%, respectively. Five cases of late malignancies (LM) were identified (malignant peripheral nerve sheath tumor, thyroid carcinoma, colon carcinoma, MDS and hepatoblastoma). Cumulative incidence of LM was 0.8% at 10 years and 2.5% at 20 years, respectively, which was lower than that in previous reports. This low incidence is in keeping with the low occurrence of skin cancer in Japanese population and of acute GVHD in our study group. Radiation-containing conditioning was not significantly associated with the incidence of LM after HSCT probably because of absolute low patient number who developed LM in our series. In terms of LM development after HSCT, low-dose TBI in HSCT for SAA to avoid graft rejection, which is commonly used in Japan, might be tolerable in the Japanese population because of its low incidence. Keywords: aplastic anemia; childhood; hematopoietic SCT; long-term outcome; late malignancies INTRODUCTION Aplastic anemia is a hematopoietic disorder characterized by pancytopenia and BM hypoplasia. Therapeutic options for severe aplastic anemia (SAA) are immunosuppressive therapy and hematopoietic SCT (HSCT). In children, if an HLA-matched sibling donor (MSD) is available, HSCT is the first line of therapy for SAA. HSCT from MSD is an established standard therapy for SAA in children and high survival rates have already been reported. However, little is known about long-term outcomes of these children.Late malignancies (LM) are serious complications for patients who undergo HSCT. 3,4 In SAA, LM are also reported in the patients with HSCT and its occurrence is related to radiation-containing conditioning regimen and GVHD grade in adults, 5,6 however, the incidence and prognostic factors of LM in children with SAA who undergo HSCT are totally unknown.In this article, we report long-term outcomes of childhood SAA patients who underwent HSCT from MSD in the centers of the Japanese Hematopoietic Cell Transplantation Registry and describe the occurrence of LM.

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Malignant Skin Tumors Among Dermatology Patients in University Hospitals of Japan

Cited by 45 publications

References 5 publications

Skin cancer in skin of color

Skin cancer in skin of color

Role of Reactive Oxygen Species in Skin Carcinogenesis

Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan

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