Malignant Solitary Fibrous Tumor of the Kidney: Report of the First Case Managed with Interferon

Cuello, Javier; Brugés, Ricardo

doi:10.1155/2013/564980

Cited by 16 publications

(22 citation statements)

References 16 publications

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“…Studies have also demonstrated that preoperative embolization may be employed prior to surgical resection for highly vascular tumors ( 26 , 27 ). Immunotherapy, for example with interferon, may also be effective ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of 47 cases of solitary fibrous tumor

Chen

et al. 2016

Oncology Letters

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The aim of the present study was to summarize the clinical manifestations, diagnosis, treatment, and prognosis of solitary fibrous tumor (SFT). In total, 47 cases of SFTs diagnosed by postoperative pathology between January 2002 and September 2014 were retrospectively reviewed, and the general information, clinical manifestations, imaging techniques, treatment, pathology and follow-up findings were analyzed. Of the 47 patients, clinical characteristics were collected in 37 cases (18 men and 19 women; mean age, 44.1 years; age range, 13–72 years). The maximum diameters of the tumors were 1.5–25 cm, with a mean diameter of 8.8 cm. The symptoms were various and non-specific. Imaging examinations following iodinated contrast administration showed the SFTs to be well-defined, cystic or solid mass and enhanced. On color Doppler ultrasound, SFTs were described as hypoechoic, clear, irregular masses. All patients underwent surgical resection, and SFT was diagnosed by postoperative pathological and immunohistochemical examination. Of the 47 patients, 25 received complete follow-up of 5–130 months, with a median follow-up period of 35.2 months, that included a color Doppler ultrasound or computed tomography (CT) scan every 6–12 months. At the end of the follow-up period all patients were alive and healthy, with the exception of one patient, who presented with recurrence 15 months after surgery. The findings of the present study showed SFT to be a rare systemic disease with no particular clinical manifestations. In the cases reviewed in the present study, CT, magnetic resonance imaging scans and color Doppler ultrasound were important for the diagnosis of SFT, while the definitive diagnosis relied on pathological and immunohistochemical examinations. Surgery, the primary treatment for SFT, was performed, and, following complete removal of the tumor, the prognosis was favorable.

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Section: Discussionmentioning

confidence: 99%

Clinical analysis of 47 cases of solitary fibrous tumor

Chen

et al. 2016

Oncology Letters

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“…SFT in the kidney is mostly benign but has malignant potential. Recently, there has been an increase in the number of reports of malignant SFT, including metastasis to lymph nodes [ 12 ], lung [ 10 , 13 , 14 ], liver [ 13 , 14 ], pancreas [ 11 ] and bone [ 15 , 16 ], local recurrence [ 17 , 3 ], peritoneal implantation [ 3 ], and invasion to renal vein [ 18 ]. Microscopically, the diagnostic criteria for malignant SFT is the presence of increased cellularity with crowded and overlapping nuclei, pleomorphism, necrosis and hemorrhage, increased mitotic activity more than four mitoses per ten high power fields (HPFs) [ 19 , 8 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Microscopically, the diagnostic criteria for malignant SFT is the presence of increased cellularity with crowded and overlapping nuclei, pleomorphism, necrosis and hemorrhage, increased mitotic activity more than four mitoses per ten high power fields (HPFs) [ 19 , 8 , 7 ]. However, some SFT patients without the malignant features in microscopy presented with distant metastasis [ 13 , 14 ] and local invasion [ 18 ], suggesting that non-malignant histology in SFT could not necessarily predict benign behavior and favorable prognosis in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion

et al. 2015

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Solitary fibrous tumor (SFT) is a rare neoplasm composed of mesenchymal-derived spindle cells. Although SFT occurs anywhere in the body, they most frequently affects the thoracic region. Here, we reported an extremely rare case of an extrathoracic SFT occurring primarily in the kidney. To our knowledge, little information has been described on the immunohistochemistry (IHC) and genetics of renal SFT.A 41-year old Japanese female came to our hospital for further examination of a left kidney mass detected incidentally with ultrasound. Extensive investigation of the tumor, including physical, laboratory, and image examinations led to a clinical diagnosis of renal cancer (cT1aN0M0), which were in most parts imbedded in the lower polar parenchyma. The patient underwent laparoscopic radical nephrectomy. The mass was diagnosed pathologically as SFT originating from the kidney, but not as renal carcinoma. Microscopically, the tumor was composed of spindle-shape cells distributed variably in dense collagenous stroma and had a focal hemangiopericytomatous staghorn-like vascular pattern. Mitotic figures, atypical structures, necrosis and hemorrhage were not identified. No adjuvant therapies were given postoperatively. The patient has been free of tumor recurrence for 25 months since the surgery. IHC revealed that the tumor diffusely expressed CD34, CD99, Bcl2, PAX8, NAB2, STAT6, and GRIA2. The tumor stained negatively for desmin, S-100, c-Kit, CK-AE1/AE3, CDK4 and MDM2. A NAB2-SATA6 gene fusion was detected in tumor cells by reverse transcription-polymerase chain reaction, direct sequencing, and an in situ proximity ligation brightfield assay. The gene fusion occurred as an 831 bp truncation of exon 2 in NAB2 connected to the beginning of exon 3 in STAT6. We have reported a case of GRIA2 and PAX8-positive SFT occurring primarily in the kidney with such NAB2-STAT6 gene fusion for the first time. Diffuse expression of PAX8 in the tumor might present with a renal origin. Reportedly, benign histology of SFT cannot necessarily predict favorable clinical prognosis. Genetic alterations recently identified in SFT could possibly refer to risk stratification for tumor recurrence. However, malignant preponderance of extrathoracic SFT over thoracic SFT remains unexplained so far. Long-term follow-up after surgery should be performed in the present case.Electronic supplementary materialThe online version of this article (doi:10.1186/s13000-015-0386-x) contains supplementary material, which is available to authorized users.

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“…It is usually found in pleura and pelvis 1 but can also occur in other unusual sites such as central nervous system, orbit, retroperitoneum, maxillary sinus, pancreas, and kidneys. 2 3 4 5 Histologically, they are characterized by proliferation of spindle cells, and immunohistochemically they are positive for CD34. 6 Usually, SFTs are benign in nature, but 10–20% of them are reported to be malignant with a tendency to metastasize.…”

Section: Introductionmentioning

confidence: 99%

Solitary fibrous tumor of the liver - An unusual entity: A case report and review of literature

Shinde

Gupta

Goel

et al. 2018

Ann Hepatobiliary Pancreat Surg

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Solitary fibrous tumor (SFT) of the liver is a rare entity and its presentation is usually delayed till they grow to a substantial size. Clinico-radiological features are non-specific, contributing to increase in the diagnostic dilemma. Definitive diagnosis of SFT is usually made based on the histological features and immunohistochemistry data of the resected specimen. In this case report, we describe the case of an elderly male who presented with a large mass in the left lobe of the liver with normal level of tumor markers and atypical radiological findings. The patient successfully underwent resection of the tumor and the diagnosis was confirmed on histopathology.

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Malignant Solitary Fibrous Tumor of the Kidney: Report of the First Case Managed with Interferon

Cited by 16 publications

References 16 publications

Clinical analysis of 47 cases of solitary fibrous tumor

Clinical analysis of 47 cases of solitary fibrous tumor

A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion

Solitary fibrous tumor of the liver - An unusual entity: A case report and review of literature

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