Malignant Solitary Fibrous Tumour of the Breast Mimicking a Benign Tumor

Barco, Israel; González, Clarisa; Vallejo, Elena; Pessarrodona, Antoni; Giménez, Núria; García-Fernández, Antonio

doi:10.1177/2632010x19868462

Cited by 5 publications

(15 citation statements)

References 14 publications

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“…Similar to SFT in any other location, complete surgical resection is the optimum treatment. Close and long-term follow-up, to monitor local or distant relapses, should be considered in both benign and malignant cases [ 12 , 13 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Lipomatous (Fat-Forming) Solitary Fibrous Tumor of the Breast: A Case Report of an Uncommon Variant of a Rare Clinical Entity

et al. 2022

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Solitary fibrous tumor (SFT) is an uncommon tumor of mesenchymal origin, which can arise at any anatomic location and can exhibit versatile histological features and a clinical course ranging from benign to frankly malignant. Lipomatous (fat-forming) SFT is a morphological variant of SFT characterized by an adipose tissue component. Breast SFT is an extremely rare clinical entity, and the literature review yielded only 28 previously reported cases. However, lipomatous (fat-forming) SFT is much less common than conventional tumors and, to our knowledge, it has never been reported in the breast. We describe a case of a 54-year-old postmenopausal woman who presented with a palpable mass on her right breast. No other associated features such as nipple discharge, skin changes, or axillary lymphadenopathy were present. The clinical differential diagnosis included fibroadenoma, phyllodes tumor, and mammary hamartoma. A ultrasound scan examination demonstrated a large, oval, well-circumscribed lesion with indeterminate features, but suspicious of malignancy. However, a needle core biopsy was performed and histological examination with ancillary immunohistochemical staining confirmed the diagnosis of SFT, a lipomatous variant. The lesion was excised with clear margins and histological examination confirmed SFT with low-risk features and follow-up was planned. Careful histological evaluation with diffuse and strong nuclear expression of STAT6 helped to distinguish lipomatous SFTs from other mimics. Here, we describe the first case of a lipomatous variant of a SFT involving the breast.

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Section: Discussionmentioning

confidence: 99%

Lipomatous (Fat-Forming) Solitary Fibrous Tumor of the Breast: A Case Report of an Uncommon Variant of a Rare Clinical Entity

et al. 2022

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“…Following our review of the literature, we found that the follow-up for breast SFT ranged from 5 to 132 months, with a local recurrence that was reported in only two cases, one treated by re-excision and the other by mastectomy. No disease-related deaths were reported [ 2 , 7 , 9 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Incidental finding of solitary fibrous tumor of male breast: case report and review of literature

El-Helou

Zaiter²,

Hoang³

et al. 2023

Rom J Morphol Embryol

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Solitary fibrous tumor (SFT) of the breast is a rare mesenchymal tumor composed of spindle-shaped tumor cells with collagen and large blood vessels in the shape of a "staghorn". It is discovered anywhere in the human body, usually incidentally or through nonspecific symptoms. A combination of clinical, histological, and immunohistochemical features is required to establish a diagnosis. There are no proper guidelines for the treatment of SFTs because of their rarity; however, wide surgical excision remains the "gold standard". A multidisciplinary team approach is recommended. They are mostly benign with a 5-year survival rate of 89%. Following a PubMed-indexed English literature review, only six publications presenting nine cases of breast SFT in a male patient were found. The following is the case of a 73-year-old man who presented with dry cough. A SFT in the right breast was discovered incidentally during the investigative work up, and the patient was referred to our Breast Clinic at the Jules Bordet Institute, Brussels, Belgium, for appropriate treatment. The patient's presentation, imaging, and histological sample all supported the diagnosis, and he underwent uneventful surgical resection. Here, we present the first case of an incidental finding of a SFT of the male breast, with its diagnosis and therapeutic challenges.

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“…19 Breast SFT often presents as a hypoechoic or inhomogeneous echoic hypervascular mass with benign features such as well-defined margins and smooth echostructure at the radiological work-up. 6 Elastography on the US is not hard. 3 Breast SFT can be shown as a relatively well-defined mass without calcifications on mammography, 9,19 and this lesion was radiologically classified under the BI-RADS category 3 18,19 or category 4.…”

Section: Discussionmentioning

confidence: 99%

“…3 Breast SFT can be shown as a relatively well-defined mass without calcifications on mammography, 9,19 and this lesion was radiologically classified under the BI-RADS category 3 18,19 or category 4. 2,10 While malignant SFTs often presented a focal lobulated appearance 3,6,21 and were often classified as BI-RADS 4C by radiologists. 3,6,21 Generally, the surgical specimen presents as a welldefined solid mass with clear boundaries.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

et al. 2022

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Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm which may arise in a wide range of anatomic location and can occur across all ages. Fat-forming SFT is a rare morphological variant of SFT. Primary breast fat-forming SFT is exquisitely rare. Here, we report a case in a 51-year-old Chinese woman with a palpable painless mass in the left breast. A color Doppler ultrasound scan examination demonstrated a 3.4-cm oval, well-circumscribed, hypoechoic solid mass with several peripheral and internal color flow signals. Magnetic resonance imaging (MRI) showed a focal lobulated solid nodular lesion displaying geographical enhancement but no architectural distortion. Subsequently, she underwent a left breast lumpectomy. In histopathologic examination, there was a well-circumscribed, cellular spindle cell tumor consisting of short fascicles of bland, fusiform, ovoid to spindle cells disposed in a patternless architecture around branching vascular spaces within a fibrous stroma with wispy collagen. Cells revealed mild nuclear atypia. Mitotic figures were up to 4/10 high-power fields (HPFs) in the hot spot. Mature adipocytes intermixed with spindle cells were also observed. The tumor cells were diffusely positive for CD34 and STAT6. Some S100-expressing adipocytes co-expressed STAT6. Next-generation sequencing (NGS) revealed the presence of the NAB2exon6::STAT6exon2 fusion. The histological, immunohistochemical (IHC) and molecular examinations confirmed the diagnosis of fat-forming SFT. Post-excision, the patient showed no signs of tumor recurrence or metastasis in a 7-month follow-up. Here, we describe a rare case of a fat-forming SFT involving the breast and highlight the comprehensive pathological evaluation and necessary ancillary testing.

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Malignant Solitary Fibrous Tumour of the Breast Mimicking a Benign Tumor

Cited by 5 publications

References 14 publications

Lipomatous (Fat-Forming) Solitary Fibrous Tumor of the Breast: A Case Report of an Uncommon Variant of a Rare Clinical Entity

Lipomatous (Fat-Forming) Solitary Fibrous Tumor of the Breast: A Case Report of an Uncommon Variant of a Rare Clinical Entity

Incidental finding of solitary fibrous tumor of male breast: case report and review of literature

A Rare Case of Breast fat-Forming Solitary Fibrous Tumor With Molecular Confirmation

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