Malignant Spitz Nevus

Skelton, Cdr Henry G.; Smith, Ltc Kathleen J.; Holland, Cdr Theresa T.; Tomaszewski, Col Maria‐Magdalena; Usa, Col George P. Lupton M.D., Mc,

doi:10.1111/j.1365-4362.1992.tb03984.x

Cited by 12 publications

(3 citation statements)

References 15 publications

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“…32 Cases excluded from this study were those that could be included within the so-called malignant Spitz nevus, [33][34][35][36] with partial extirpations, or without 2 or more recorded clinical data; accordingly, 29 cases were excluded.…”

Section: Methodsmentioning

confidence: 99%

Spitz Nevus: A Clinicopathological Study of 349 Cases

Requena

Requena²,

Kutzner³

et al. 2009

The American Journal of Dermatopathology

160

143

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Spitz nevus is an infrequent, usually acquired melanocytic nevus composed of epithelioid and/or spindle melanocytes that can occasionally be confused with melanoma. Currently, there are no immunohistochemical markers or molecular biology techniques that can be used to make an entirely safe diagnosis of Spitz nevus or melanoma in problematic cases. A retrospective study has been carried out that included all the cases diagnosed as Spitz nevus from our files. Follow-up information of the patients was unavailable. Three hundred forty-nine cases of unequivocal Spitz nevi were included, and their clinical and histopathological parameters were reviewed. One hundred and forty patients (40%) were 15 years old or younger, with a male to female ratio of 1:1. In patients older than 15 years, there was an evident predominance of women, with a male to female ratio of around 1:3. Spitz nevus was most commonly located on the lower extremities, followed by the trunk in both children and adults. Despite the fact that the head and neck were the third most common location in children, it was a much more frequent location in children than in adults. The constitution by epithelioid and/or spindled cells was the only histopathological finding present in 100% of cases. The other pathological findings studied were, from more to less frequent: maturation (72%), inflammatory infiltrate (70%), epidermal hyperplasia (66%), melanin (50%), telangiectasias (40%), Kamino bodies (34%), desmoplastic stroma (26%), mitosis (23%), pagetoid extension (13%), and hyalinization of the stroma (8%). Hyalinization was the only histopathological parameter that was statistically more frequent in adults than in children.

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Section: Methodsmentioning

confidence: 99%

Spitz Nevus: A Clinicopathological Study of 349 Cases

Requena

Requena²,

Kutzner³

et al. 2009

The American Journal of Dermatopathology

160

143

View full text Add to dashboard Cite

show abstract

“…Indeed, in 1989 and 1992, a group from Armed Forces Institute of Pathology instituted the term ‘metastasizing Spitz nevus,’14, 15 which, due to the identification by a biologic potential (if it metastasizes, it is melanoma), became synonymous in later years with a type of malignant melanoma with Spitz nevus-like cytology, later deemed a Spitzoid melanoma. The entity known as Spitz nevus was first described by Sophie Spitz in 1948,16 denoting these as “melanomas of childhood.” Clinically, these lesions present as benign, small, and asymptomatic superficial skin tumors that are dome-shaped and usually pink or tan, but also sometimes brown or black.…”

Section: Biopathology Of Melanoma In the Pediatric Adolescent And Ymentioning

confidence: 99%

Melanoma in Pediatric, Adolescent, and Young Adult Patients

Kirkwood

Jukic

Averbook

et al. 2009

Seminars in Oncology

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The family practitioner, pediatrician, and dermatologist each have potential roles in the primary prevention, diagnosis, and treatment of localized thin melanomas. Surgical and medical oncologists are often involved when controversy arises over the nature of the skin lesion or whether sentinel lymph node (SLN) biopsies and adjuvant therapy are to be contemplated. This overview of melanoma will deal with the primary and nodal pathology, surgery, and medical therapy of melanoma in pediatric, adolescent, and young adult patients-and will raise areas of controversy that are only recently being addressed in databases of cases from this age group.

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“…The prognosis of spitzoid melanoma in children has been suggested to be better than that observed in adults; however, this assertion remains controversial. Although spitzoid melanomas with regional lymph node metastasis with no further progression have been reported, cases leading to widespread metastasis and fatal outcomes are also well documented 5, 9–11. Due to the rarity of these tumors, large studies with long‐term follow‐up are lacking.…”

mentioning

confidence: 99%

Influence of age on survival in childhood spitzoid melanomas

Pol-Rodriquez

Lee

Silvers

et al. 2007

Cancer

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BACKGROUND. Melanoma occurring during childhood and adolescence is rare. Although a few limited studies suggest that the prognosis of childhood melanomas is similar to those in adults, and is dependent on the initial stage of the tumor, there is controversy with respect to the biologic behavior of childhood melanomas. Spitzoid melanoma is a subtype of melanoma with distinct clinical and histopathologic features. The prognosis of spitzoid melanoma in children, despite metastasis, has been suggested to be better than that observed in adults; however, this assertion remains controversial. Whereas a number of spitzoid melanomas with regional lymph node metastasis with no further progression have been reported, cases leading to widespread metastasis and fatal outcomes are also well documented. METHODS. A retrospective review of the literature was conducted between 1949 and 2006. A total of 82 cases of spitzoid melanoma with regional and/or widespread metastasis that occurred in children, 17 years of age and under, were selected for the analysis. RESULTS. The 5‐year survival rate in children diagnosed with metastatic spitzoid melanomas between 0 and 10 years of age was 88% compared with 49% in those between 11 and 17 years of age. CONCLUSIONS. The findings support the notion that younger age (≤10) may be associated with longer survival in children with metastatic spitzoid melanomas. Cancer 2007. © 2007 American Cancer Society.

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Malignant Spitz Nevus

Cited by 12 publications

References 15 publications

Spitz Nevus: A Clinicopathological Study of 349 Cases

Spitz Nevus: A Clinicopathological Study of 349 Cases

Melanoma in Pediatric, Adolescent, and Young Adult Patients

Influence of age on survival in childhood spitzoid melanomas

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