Malignant testicular tumors in three brothers

Mikulíček, I.; Mikuláštík, J; Sobotka, Paul A.

doi:10.1007/bf02082095

Cited by 10 publications

(1 citation statement)

References 4 publications

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“…We report the first case of testicular cancer in three brothers from the UK and probably the third in the world. 2 A 26 year old brother of Cases 1 and 2 presented with swelling of the right testis in 1986. Orchidectomy revealed two tumours, a malignant teratoma intermediate in the lower pole, and a seminoma in the upper pole of testis.…”

Section: Introductionmentioning

confidence: 99%

Testicular cancer in three brothers

Raina

Young

Soukop

1989

Postgraduate Medical Journal

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Summary:Three of four brothers in a family were diagnosed to have testicular tumour. AU brothers were in their twenties at diagnosis and all had malignant teratoma, intermediate. One of the brothers, in addition, had a seminoma on the same side as the teratoma. The cases were unusual as there was no family history of cancer and no congenital abnormalities, such as cryptorchidism. Chromosomal analysis and HLA typing did not help in elucidating the cause of this rare familial occurrence of testicular tumour.

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Section: Introductionmentioning

confidence: 99%

Testicular cancer in three brothers

Raina

Young

Soukop

1989

Postgraduate Medical Journal

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Father-son testicular malignancy does genetic anticipation occur?

Jelihovsky

Fox

1980

Cancer

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Testicular malignancy in a father and son is reported. The father had sequential bilateral seminomas while the son had embryonal cell carcinoma and seminoma. Reported cases of father-son testicular malignancy are reviewed and a predominance of seminomas in the fathers is apparent while the sons' tumors are highly malignant teratomas, choriocarcinomas and embryonal cell carcinomas. The possibility of genetic anticipation in father-son testicular malignancy is discussed.

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Testicular neoplasms occurring in four brothers. A search for a genetic predisposition

Gedde‐Dahl

Waksvik

Brøgger

et al. 1985

Cancer

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Four brothers who developed testicular neoplasms, one bilaterally, are described. Histologic examination showed four of the tumors to be seminomas and one to be a mixed germ cell tumor. Three of the brothers are alive. Apart from a late‐onset bladder carcinoma in their father and a pulmonary cancer in a maternal uncle, cancers were not recorded in the extended kindred. One patient, a sister, and the parents had normal frequency of sister chromatid exchange (SCE) and chromosome aberrations, whereas the two patients sampled after radiation showed increase in one or both. The father was found heterozygous in 12 and the mother in 8 genetic marker systems among 25 tested. For the blood group gene loci JK and MNSs, and the erythrocyte enzyme locus GPT the father had given the same allele to all three affected sons examined. The mother had given different alleles to the sons in all of her informative markers. On the model of a recessively acting susceptibility gene, only JK and GPT remained consistent with linkage without recombination. These investigations did not add support to a genetic etiology for the unusual family occurrence of testicular cancer. An apparent birth‐order effect on time at onset/diagnosis in this and published families suggests time‐limited environmental factors. Nevertheless, JK, MNSs, and GPT should be included in future testis cancer families to test the model of a “dominant” genetic predisposition.

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Malignant testicular tumors in three brothers

Abstract: Three brothers out of four had malignant testicular tumors. The first of them had choriocarcinoma, the second seminoma, and the third teratocarcinoma of the testis.

Cited by 10 publications

References 4 publications

Testicular cancer in three brothers

Testicular cancer in three brothers

Father-son testicular malignancy does genetic anticipation occur?

Testicular neoplasms occurring in four brothers. A search for a genetic predisposition

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