Malignant thrombosis of the superior vena cava caused by non-small-cell lung cancer treated with radiation and erlotinib: a case with complete and prolonged response over 3 years

Wang, Jianyang; Liang, Jun; Wang, Wenqing; Ouyang, Han; Wang, Lühua

doi:10.2147/ott.s45660

Cited by 2 publications

(4 citation statements)

References 22 publications

(21 reference statements)

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“…The presence of metastasis is an important prognostic factor for SVCS of neoplastic origin. 3,5,[9][10][11] Survival in our patients was better for localized or locally advanced stages but the difference was statistically insignificant. Concerning cancer treatment, a better survival was noted under chemotherapy (8 months) with a statistically significant difference in case of NSCLC (p<10 -3 ) and in case of SCLC (p<10 -3 ) in our series.…”

Section: Discussionmentioning

confidence: 50%

“…It is reported in the literature that life expectancy in patients with tumour SVCS is 6 months, but this estimation varies widely depending on the underlying neoplastic conditions. 8,9 According to some authors, the SVCS itself is not a factor of poor prognosis since overall survival does not differ for BPC of the same histological type and same stage according to the existence or not of SVCS. 5,6,8 Most studies have found that age is an important factor influencing the prognosis of SVCS of pulmonary neoplastic origin with a survival that deteriorates with age.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that the survival of patients with NSCLC is better compared with those with SCLC. 8,9 On the other hand, Wilson LD reported in his study that the prognosis of SVCS with neoplastic origin depends on histological type of the tumor and its response to treatment. He concluded that SCLC was correlated with better survival.…”

Section: Discussionmentioning

confidence: 99%

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Superior vena cava syndrome and lung cancer: survival and prognostic factors

Migaou

Fahem

Saad

et al. 2019

JLPRR

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Introduction: The superior vena cava syndrome (SVCS) is a set of signs related to the obstruction of the upper cava current caused by a compression, an invasion or a thrombosis of the superior vena cava. Its etiologies are numerous but dominated by neoplastic causes mainly of bronchopulmonary origin. Aim of the work: The aim of this study is to evaluate survival and to identify the prognostic factors of superior vena cava syndrome in patients with lung cancer. We also propose to draw up the clinical profile as well as the therapeutic management in SVCS of malignant origin. Materials and methods: A total of 108 patients with SVCS complicating primary bronchial cancer were hospitalized in the Pneumology Department at Fattouma Bourguiba University Hospital during a period of 25 years. Results: The results showed the existence of a clear male predominance (98.1%) and an average age of 60.2 years. Smoking was found in 68.5% of cases .The superior vena cava syndrome revealed a neoplasm in 55% of cases and it was metachronous in 30.5% of cases. Median survival was 7months. In univariate study, survival was reduced in patients having general health impairment with Performans Status (PS) score≥2, signs of severity of SVCS, altered respiratory function, chronic respiratory failure, histological type of non small cell lung carcinoma and exclusive symptomatic treatment for bronchopulmonary cancer. Multivariate analysis revealed that gender, smoking, PS score and signs of severity were independent prognostic factors. Conclusion: The management of the SVCS is multidisciplinary. It requires medical treatment whose effectiveness is still uncertain and radiotherapy which is considered the gold standard of treatment for SVCS.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Superior vena cava syndrome and lung cancer: survival and prognostic factors

Migaou

Fahem

Saad

et al. 2019

JLPRR

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“…Furthermore, intraluminal metastasis to the SVC from DASCs has not been reported previously. To date, only a limited number of cases of malignant neoplasms of the skin ( 12 , 13 ), prostate ( 14 ), lung ( 15 ), thyroid ( 16 ), thymus ( 17 ) and colon ( 18 ) with intraluminal metastases to the SVC have been reported ( Table I ). We hypothesize that metastases to the large vessels are extremely rare due to the high volume and speed of blood flow, and the thick sub-endothelial layer, which prevent invasion by tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum: A case report

et al. 2015

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In 2013, a 76-year-old male with a cardiac pacemaker was diagnosed with adenosquamous carcinoma of the duodenum. Subsequently, a pancreatoduodenectomy and lymph node dissection were performed, and 12 cycles of adjuvant chemotherapy (modified FOLFOX6 regimen), which consisted of fluorouracil, leucovorin and oxaliplatin, were administered via a central venous catheter. At 5 months after the completion of adjuvant chemotherapy, the patient experienced the sudden onset of severe pain at the back right of the ear, edema of the right side of the face and right jugular vein dilatation. Computed tomography (CT) revealed filling defects in the superior vena cava (SVC) and right brachiocephalic vein, indicating catheter-induced venous thrombosis. Although the catheter was removed and anti-coagulation therapy, aspiration of the thrombosis and ballooning dilatation were performed immediately, the patient's symptoms were not ameliorated. Notably, histological examination following thrombus aspiration revealed metastatic cancer cells, and fluorodeoxyglucose-positron emission tomography/CT identified metabolically active nodules in the SVC at locations consistent with the initial duodenal tumors detected by CT and in the first thoracic vertebrae. The tumor thrombus rapidly increased in size and resulted in worsening dyspnea. Subsequently, radiotherapy was performed, followed by chemotherapy, which relieved the systemic symptoms and suppressed the tumor growth. Adenosquamous carcinoma of the duodenum is extremely rare, and to the best of our knowledge, intraluminal SVC metastasis as a result of adenosquamous carcinoma of the duodenum has not been reported previously. The placement of a cardiac pacemaker, central venous catheter and tumor cells possessing high metastatic potential are hypothesized to have contributed to this rare case of metastasis.

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Malignant thrombosis of the superior vena cava caused by non-small-cell lung cancer treated with radiation and erlotinib: a case with complete and prolonged response over 3 years

Cited by 2 publications

References 22 publications

Superior vena cava syndrome and lung cancer: survival and prognostic factors

Superior vena cava syndrome and lung cancer: survival and prognostic factors

Intraluminal superior vena cava metastasis from adenosquamous carcinoma of the duodenum: A case report

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