Malignant transformation from mature cystic teratoma of the ovary

Shimada, Takako; Higashijima, Ai; Fukushima, Ayako; Komatsu, Naoya; Noguchi, Masashi; Ohashi, Kazuaki; Hasegawa, Yuri; Miura, Kiyonori

doi:10.1111/jog.14043

Cited by 8 publications

(5 citation statements)

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“…According to a recently published systematic review, it seems that early hysterectomy and platinum-based chemotherapy could be associated with better survival; however, this result should be interpreted with caution [10]. The most common chemotherapy regimen used in these patients is the same used for ovarian epithelial cancers, but despite multidisciplinary management, there are still a high recurrence and mortality rate [11,12]. Patni et al, similarly to our study, has used the combination of carboplatin and paclitaxel regimen [13].…”

Section: Discussionmentioning

confidence: 99%

Ovarian mature cystic teratoma with malignant transformation: two case reports

et al. 2021

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Background Mature Cystic Teratoma (MCT) is a benign tumor that can lead to malignant transformation (MT) in 1–3% of cases. Management of MT is a big challenge for gynecologic oncologists due to the lack of specific diagnostic and treatment protocols. Case presentation We reported two Iranian cases of MT of MCT with two different stages and prognosis. Our both cases presented the same symptoms, including chronic abdominal pain and distention, loss of appetite, and weight loss. In case number 1, despite the large size of the tumor, the disease was at stage Ia and had a good prognosis; while, case number 2 was at stage IIIc of the disease with a poor prognosis. Conclusion The stage of the disease is the most important prognostic factor, and early diagnosis and treatment are very critical for better survival.

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Section: Discussionmentioning

confidence: 99%

Ovarian mature cystic teratoma with malignant transformation: two case reports

et al. 2021

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“…Some reports also con rmed that tumors are not sensitive to chemotherapy [15]. Although some patients have received chemotherapy and multidisciplinary management, the recurrence rate and mortality rate are still high [19].However, according to a recently published systematic review, early hysterectomy and platinum chemotherapy appear to be associated with better survival [20].Our patient underwent laparoscopic partial colectomy, hysterectomy, and bilateral appendage resection. The patient did not receive chemotherapy and radiotherapy, and at 6 months post-treatment, no evidence of recurrence or metastasis was found.…”

Section: Discussionmentioning

confidence: 65%

Ovarian mature cystic teratoma with papillary thyroid carcinoma and carcinoid components invading the adjoining sigmoid colon: A case report

Liu

2023

Preprint

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Background: Malignant transformation of ovarian mature cystic teratoma rarely develops, especially when multiple malignant components simultaneously occur. Case presentation:A 47-year-old woman presented with a 12-month history of intermittent abdominal distension and pain along with bloody stool for 3 weeks. Abdominal computed tomography revealed a cystic mass in the right ovary adjacent to the colon. Additionally, fluids were observed in the colon cavity . Colonoscopy showed a protuberant mass on the surface of the sigmoid colon covered with blood . Considering the large size of the colonic mass and the undetermined diagnosis of the mass, the patient underwent laparoscopic partial colectomy, hysterectomy, and bilateral appendage resection.Grossly, the ovarian cyst was connected to the colon wall, and the cut surface of the colon tumor was cystic and contained mucus. Histopathological examination revealed that the surface of colonic lesions was the granulation tissue, and the lower part was composed of fibrous stroma and mucinous cyst. The cyst wall was covered with columnar cells and contained abundant intracellular mucin. No nuclear atypia was observed. The lesions penetrated the entire intestinal wall and connected with ovarian cysts. Mucus, lipids, and hair could be observed in the ovarian cyst cavity. Histopathological examination showed that the cyst wall was lined with stratified squamous epithelium, and the sebaceous glands could be observed in the fibrous stroma of the cyst wall. Thyroid follicular components could be found in the surrounding area, and some cells were arranged in a chrysanthemum-like cluster . Under high magnification, the nuclei of these cells were characterized as pepper-salt-like . In another area, the typical papillary structure of papillary thyroid carcinoma and the formation of multiple cysts containing mucus were observed; some of which were lined with columnar epithelium containing goblet cells . Under high magnification, the nuclei of these papillae were crowded, ground glass-like, with nuclear grooves. Notably, no malignant tumor components were observed in the colon wall and colon polyps, which are only composed of benign mucinous epithelium. Based on these findings, the patient was suspected of ovarian mature cystic teratoma, which contained mucinous cysts, carcinoids, goiters, and papillary thyroid carcinoma. Moreover, mucinous cysts involved the colon wall and formed a polypoid appearance. At the time of this writing, 6 months had passed since treatment completion, without clinical or histological evidence of recurrence. Conclusion: Herein, we present a rare case of malignant ovarian mature cystic teratoma, including mucinous cysts, goiters, papillary thyroid carcinoma, and carcinoids. The tumor remarkably invaded the intestinal wall and formed a benign polypoid appearance, suggesting the occurrence of this rare tumor type should be considered when intestinal polyps are found during gastrointestinal endoscopy.

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“…The most common malignant transformation is squamous cell carcinoma with an incidence of around 0.2%–0.8%. 6 We here discuss a case of the 80‐year‐old woman where mature cystic teratoma has been transformed into undifferentiated carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…However, in rare cases, it might transform into a malignant form. The most common malignant transformation is squamous cell carcinoma with an incidence of around 0.2%–0.8% 6 …”

Section: Discussionmentioning

confidence: 99%