Malignant transformation in a cohort of patients with oral epithelial dysplasia

Hankinson, Paul; Mohammed‐Ali, Ricardo; Smith, Alexander; Khurram, Syed Ali

doi:10.1016/j.bjoms.2021.02.019

Cited by 14 publications

(7 citation statements)

References 9 publications

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“…When previously diagnosed, potentially malignant lesions become conclusive, enabling their identification and indication for the most appropriate treatment (Tanriver et al, 2021). Considering that cases of mild, moderate and severe OED can progress to an oral squamous cell carcinoma, in which its evolution occurs according to the change in the diagnosed grade, early diagnosis is essential for treatment (Pritzker et al, 2021;Hankinson et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Clinical resolution in diagnosis of leukoplastic lesion associated with oral dysplasia: case report

Freire

Júnior

Cavalcante

et al. 2023

RSD

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The objective of the present study is to report a clinical case that emphasizes the diagnosis of mild epithelial dysplasia located in the unilateral region of the buccal mucosa. Patient, 49 years old, female, pheoderma, attended the dental clinic of the Nilton Lins University, referring a dental fracture as the main reason for the consultation. The intraoral clinical examination revealed a unilateral lesion in the buccal mucosa with plaque characteristics and whitish coloration. Initially, it was decided to perform an excisional biopsy of the lesion with a diagnostic hypothesis of lichen planus. The extracted pieces were sent to the Department of Pathology and Legal Medicine of the Federal University of Amazonas School of Medicine for confirmation of the diagnostic hypothesis, confirmed by the report as mild epithelial dysplasia. Subsequently, the patient was referred to perform the other dental procedures that were later scheduled and is under follow-up, with no complaints or adverse complications. Therefore, given the clinical resolution presented, the differential diagnosis was essential, enabling a satisfactory clinical conduct.

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Section: Discussionmentioning

confidence: 99%

Clinical resolution in diagnosis of leukoplastic lesion associated with oral dysplasia: case report

Freire

Júnior

Cavalcante

et al. 2023

RSD

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“…At the same time, it is generally accepted that OED is a premalignant lesion [ 3 , 44 ]. Recently (2021), Hankinson et al reported that 2.6% of cases with mild OED, 4.1% of cases with moderate OED, and 29.2% of cases with severe OED progressed to OSCC at the dysplastic site and a small number developed a malignant lesion in other locations [ 45 ]. There is a wide field for further research in the future because bulky epithelial proliferation may be attributed to VDAC1 overexpression while epithelial atrophy may be a sign of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions

et al. 2023

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Background: The voltage-dependent anion channel 1 protein (VDAC1) plays a role in cellular metabolism and survival. It was found to be down or upregulated (overexpressed) in different malignancies but it was never studied in application to oral lesions. The purpose of this study was to retrospectively evaluate the expression of VDAC1 in biopsies of oral premalignant, malignant, and malignancy-neutral lesions and to examine the possible correlations to their clinicopathological parameters. Materials and methods: 103 biopsies including 49 oral squamous cell carcinoma, 33 epithelial dysplasia, and 21 fibrous hyperplasia samples were immunohistochemically stained with anti-VDAC1 antibodies for semi-quantitative evaluation. The antibody detection was performed with 3,3′-diaminobenzidine (DAB). The clinicopathological information was examined for possible correlations with VDAC1. Results: VDAC1 expression was lower in oral squamous cell carcinoma 0.63 ± 0.40 and in oral epithelial dysplasia 0.61 ± 0.36 biopsies compared to fibrous hyperplasia biopsies 1.45 ± 0.28 (p < 0.01 for both; Kruskal–Wallis test). Conclusion: Oral squamous cell carcinoma and epithelial dysplasia tissues demonstrated decreased VDAC1 protein expression if compared to fibrous hyperplasia samples, but were not different from each other, suggesting that the involvement of VDAC1 in oral carcinogenesis is an early stage event, regulating cells to live or die.

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“…As moderate and severe dysplastic lesions are often excised, the true transformation rates are more difficult to estimate. Time to transformation is also variable [12,13]. An alternative two-tier system of 'low' risk for no/questionable risk lesions or 'high' risk for moderate/severe risk lesions has been proposed, with a need for further longitudinal studies [14].…”

Section: Leukoplakiamentioning

confidence: 99%

Oral potentially malignant disorders: advice on management in primary care

Eccles

Carey

Cook

et al. 2022

J Oral Med Oral Surg

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Introduction: The diagnosis of and risks associated with oral potentially malignant disorders (OPMD) have been widely reported, but little has been published on the management of OPMDs in a primary dental care setting. Hospital services face ongoing pressures due to long-term follow-up, with a need for surveillance to be jointly undertaken with primary dental care clinicians. In a primary care setting, identification and surveillance of OPMDs can be challenging as no universal guidance exists on recommended recall intervals. Corpus: In this article, an update on OPMDs is provided and, based on the practices of six Oral Medicine units in Europe (London (United Kingdom), Milan (Italy), Bordeaux (France), Porto (Portugal), Zagreb (Croatia) and Santiago de Compostela (Spain)), aiming to provide guidance on monitoring in a primary care setting in Europe. Conclusion: Oral medicine clinicians can provide guidance to general dental practitioners (GDPs) on recommended recall intervals. It is important that they feel confident in monitoring these conditions and, when concerned, to arrange referral to a hospital or appropriate specialist. GDPs should document descriptions of lesions and, if possible, take clinical photographs. Patients should be counselled on modifiable lifestyle factors and directed to oral medicine society websites to access patient information leaflets.

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Malignant transformation in a cohort of patients with oral epithelial dysplasia

Cited by 14 publications

References 9 publications

Clinical resolution in diagnosis of leukoplastic lesion associated with oral dysplasia: case report

Clinical resolution in diagnosis of leukoplastic lesion associated with oral dysplasia: case report

Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions

Oral potentially malignant disorders: advice on management in primary care

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