Malignant transformation in a thymic cyst

Leong, Anthony Y.; Brown, Jeffrey G.

doi:10.1097/00000478-198406000-00009

Cited by 72 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patients in our study have showed no recurrence. Recurrences as well as malignant transformation have been reported only in adults, not in children [38,39]. Long-term prognosis in children is excellent.…”

Section: Discussionmentioning

confidence: 99%

Cervical thymic cysts

et al. 2007

View full text Add to dashboard Cite

Thymic cysts are rare embryonic remnants along the course of thymic migration in the neck or the anterior mediastinum which may result in cervical masses in children, often misdiagnosed. We present the experience gained by three European tertiary care medical centers in the treatment of thymic cysts as well as the current data on the embryology, clinical presentation, diagnosis and management of thymic cysts. A retrospective study was carried out in nine patients with thymic cysts during the period 1986-2002 at the departments of Pediatric Surgery of Children's University Hospital "Federico II" and "Santobono" Pediatric Hospital of Naples in Italy and "Aghia Sophia" Children's Hospital of Athens in Greece. All cases were asymptomatic, appearing mainly as masses resembling branchial cyst or lymphatic malformation. Laboratory and imaging investigations were not useful for preoperative diagnosis. In one case the mass extended into the mediastinum. The histological findings of thymic tissue and Hassal's corpuscles in the cystic wall were diagnostic. In all cases, surgery was successful and uneventful. Surgical excision was accomplished by dissection of the cystic masses from the jugular vein, carotid artery and vagus nerve and from the sternocleidomastoid muscle. The presence of a normal thymus in the mediastinum must be documented preoperatively in order to avoid the risk of total thymectomy. If a cervical thymic cyst extends into the normal thymus, attempts should be made to preserve the thymus, especially in younger patients. Thymic cysts should always be included in the differential diagnosis of lateral cervical masses, especially in children.

show abstract

Section: Discussionmentioning

confidence: 99%

Cervical thymic cysts

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Clinical features, diagnosis and thoracoscopic surgical treatment of thymic cysts cysts, malignant transformation or compression of the surrounding organs in the mediastinum, can arise in some patients (1,3). However, there is no guidance regarding the optimal surgical approach for thymic cysts (4).…”

Section: Original Articlementioning

confidence: 99%

Clinical features, diagnosis and thoracoscopic surgical treatment of thymic cysts

Wang

Xiao

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

Background: Thymic cysts are rare benign developmental anomalies and there is no consensus management for thymic cysts. The aim of this study was to disclose the efficacy of perioperative diagnosis for thymic cysts by chest computerized tomography (CT) and to elucidate the surgical procedure by videoassisted thoracic surgery (VATS) in the management of thymic cysts. Conclusions: A diameter ≤3 cm and an unenhanced CT value >20 Hu were independent factors of incorrect diagnosis of chest CT. VATS is a reliable approach for the surgical resection of thymic cysts. We think that local resection is adequate for simple thymic cysts. However, thymectomy is necessary when there is suspicion of a thymoma or multilocular thymic cyst, and radical thymectomy is advisable for patients with autoimmune diseases.

show abstract

“…2,3,7,8,14,15 We herein present 7 cases of thymic carcinoma associated with MTC. The histologic tumor types in our cases included squamous cell carcinoma, sarcomatoid (spindle) cell carcinoma, papillary carcinoma, and basaloid carcinoma, thereby expanding the morphologic range of tumors associated with cystic changes of the MTC type.…”

mentioning

confidence: 97%

Thymic Carcinoma Associated With Multilocular Thymic Cyst

Weissferdt

Moran

2011

American Journal of Surgical Pathology

View full text Add to dashboard Cite

We present 7 cases of thymic carcinoma associated with a multilocular thymic cyst (MTC). The patients were 5 men and 2 women aged 22 to 71 years (mean, 49.3 y). Clinically, 6 patients presented with chest, sternal, or upper extremity pain, and in 1 patient the tumor was an incidental finding. Grossly, 4 tumors were described as multilobulated solid-cystic masses, whereas 3 cases were described as solid tumors with a white-yellow cut surface and areas of hemorrhage and necrosis. The tumor size ranged from 7.0 to 10.0 cm (mean, 8.1 cm). Histologically, 4 cases were classified as squamous cell carcinoma, and 1 each as sarcomatoid (spindle) cell carcinoma, papillary carcinoma, and basaloid carcinoma. In addition to the tumor component, prominent MTC changes were observed in the adjacent remnant thymic tissue. Immunohistochemical studies were conducted in 2 cases of squamous cell carcinoma. The neoplastic cells were positive for cytokeratin (CK), CK5/6, and p63, and showed variable reactivity for CK7 and CD5. Clinical follow-up showed that 4 patients were alive and well, 2 to 63 months after diagnosis, and 3 patients were alive with disease, 13 to 33 months after diagnosis. This study expands the morphologic spectrum of thymic carcinoma associated with MTC, detects a higher incidence than previously believed, and highlights the importance of adequate sampling and proper evaluation of all cystic lesions of the anterior mediastinum so as not to mistake malignancy for a benign cystic process.

show abstract

Malignant transformation in a thymic cyst

Cited by 72 publications

References 0 publications

Cervical thymic cysts

Cervical thymic cysts

Clinical features, diagnosis and thoracoscopic surgical treatment of thymic cysts

Thymic Carcinoma Associated With Multilocular Thymic Cyst

Contact Info

Product

Resources

About