Malignant Transformation in Mature Cystic Teratomas of the Ovary: Case Reports and Review of the Literature

Gadducci, Angiolo; Pistolesi, Sabina; Guerrieri, Maria Elena; Cosio, Stefania; Carbone, Francesco Giuseppe; Naccarato, Antonio Giuseppe

doi:10.21873/anticanres.12644

Cited by 14 publications

(24 citation statements)

References 45 publications

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“…75 Moreover, although mature cystic teratoma hardly undergoes malignant transformation, the possibility of such incidence increases with age. [76][77][78] Overall, the close relations between ovarian benign lesions and carcinoma incidences highlight the importance of study of benign lesion microenvironment. Our results indicated that different ovarian benign lesions have undergone significant alterations according to their pathological states, with highest variations in their ECM elasticity most probably due to cell remodeling which affects ECM synthesis and regulation.…”

Section: Dovepressmentioning

confidence: 99%

<p>An AFM-Based Nanomechanical Study of Ovarian Tissues with Pathological Conditions</p>

Ansardamavandi¹,

Tafazzoli-Shadpour²,

Omidvar³

et al. 2020

IJN

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Background: Different diseases affect both mechanical and chemical features of the involved tissue, enhancing the symptoms. Methods: In this study, using atomic force microscopy, we mechanically characterized human ovarian tissues with four distinct pathological conditions: mucinous, serous, and mature teratoma tumors, and non-tumorous endometriosis. Mechanical elasticity profiles were quantified and the resultant data were categorized using K-means clustering method, as well as fuzzy C-means, to evaluate elastic moduli of cellular and non-cellular parts of diseased tissues and compare them among four disease conditions. Samples were stained by hematoxylin-eosin staining to further study the content of different locations of tissues. Results: Pathological state vastly influenced the mechanical properties of the ovarian tissues. Significant alterations among elastic moduli of both cellular and non-cellular parts were observed. Mature teratoma tumors commonly composed of multiple cell types and heterogeneous ECM structure showed the widest range of elasticity profile and the stiffest average elastic modulus of 14 kPa. Samples of serous tumors were the softest tissues with elastic modulus of only 400 Pa for the cellular part and 5 kPa for the ECM. Tissues of other two diseases were closer in mechanical properties as mucinous tumors were insignificantly stiffer than endometriosis in cellular part, 1300 Pa compared to 1000 Pa, with the ECM average elastic modulus of 8 kPa for both. Conclusion: The higher incidence of carcinoma out of teratoma and serous tumors may be related to the intense alteration of mechanical features of the cellular and the ECM, serving as a potential risk factor which necessitates further investigation.

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Section: Dovepressmentioning

confidence: 99%

<p>An AFM-Based Nanomechanical Study of Ovarian Tissues with Pathological Conditions</p>

Ansardamavandi¹,

Tafazzoli-Shadpour²,

Omidvar³

et al. 2020

IJN

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“…Struma ovarii is a rare monodermal ovarian teratoma which contains at least 50% of thyroid tissue: its prevalence among all ovarian tumors is 0.3-1% ( 6) and 2% among mature cystic teratomas (7). Malignant mature cystic teratoma transformation has been reported in 5-10% of cases, while metastasis can develop in about 5-23% of malignant mature cystic teratomas (8). If the mass is big patients may suffer from abdominal pain or constipation, but strumal carcinoids are sometimes just incidental findings.…”

Section: Review Of the Literaturementioning

confidence: 99%

Metastatic Bilateral Strumal Carcinoid: A Case Report and Review of the Literature

et al. 2019

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Primary ovarian carcinoids are very rare tumors that belong to the germ cell family of ovarian malignancies. They account for less than 1% of all carcinoid tumors and for less than 0.1% of all ovarian neoplasms. Recurrences are even rarer, with only few cases reported in the literature. Strumal carcinoid has recently been recognized as an extremely rare distinct entity. We report on a patient with bilateral mature cystic teratoma with millimetric foci of ovarian strumal carcinoid who developed lymph node para aortic metastasis after 30 years from primary diagnosis. Our case is thus far the second report of a metastatic strumal carcinoid and the first one in which strumal carcinoid occurred bilaterally and was also metastatic.

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“…Mature cystic teratomas of the ovary have an incidence of approximately 1.2-14.2 cases per 100.000 women per year, accounting for 60% of all benign ovarian tumors, and may occur at any age, with the highest peak between 30 and 40 years (1,2). These ovarian germ cell tumors undergo malignant transformation in approximately 2% of the cases, and squamous cell carcinoma is the most commonly associated cancer (1,3,4). Less frequently encountered neoplasias are represented by mucinous carcinomas (5,6), thyroid carcinomas (3,(5)(6)(7)(8)(9), carcinoids (5,10), neuroectodermal tumors (11,12) and sarcomas (13).…”

mentioning

confidence: 99%

“…These ovarian germ cell tumors undergo malignant transformation in approximately 2% of the cases, and squamous cell carcinoma is the most commonly associated cancer (1,3,4). Less frequently encountered neoplasias are represented by mucinous carcinomas (5,6), thyroid carcinomas (3,(5)(6)(7)(8)(9), carcinoids (5,10), neuroectodermal tumors (11,12) and sarcomas (13).…”

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confidence: 99%

“…The mainstay of therapy of squamous cell carcinoma arising in a mature cystic teratoma of the ovary consists of bilateral salpingo-oophorectomy, total hysterectomy and comprehensive surgical staging in early carcinoma and optimal debulking surgery in advanced carcinoma (2,3,4). The role of postoperative platinum-based chemotherapy is uncertain in patients with stage I disease, whereas it is a standard of care in those with more advanced disease (1-4, 17, 18).…”

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confidence: 99%

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Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study

et al. 2019

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Background/Aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma. Patients and Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39.1%) patients had squamous cell carcinoma, five (21.7%) had a thyroid carcinoma, six (26.1%) had a carcinoid, one (4.3%) patient had papillary renal carcinoma, one (4.3%) had medulloblastoma and one (4.3%) had intestinal-type mucinous adenocarcinoma. Results: All six patients with stage I squamous cell carcinoma had no evidence of disease (NED) after a median time of 141 months. Of the three patients with stage IIb-IIIc squamous cell carcinoma, two had NED after 119 and 154 months, and one died of the disease 9 months after diagnosis. All five women with stage I thyroid carcinoma had NED after a median of 60 months. Of the six patients with stage I carcinoid, five had NED after a median of 168 months, whereas one died due to carcinoid heart disease. The three patients with stage I renal carcinoma, medulloblastoma and mucinous adenocarcinoma had NED after 24, 141 and 149 months, respectively. Conclusion: The clinical outcome of early-stage malignancies associated with mature ovarian teratomas is excellent following treatment.

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Malignant Transformation in Mature Cystic Teratomas of the Ovary: Case Reports and Review of the Literature

Cited by 14 publications

References 45 publications

<p>An AFM-Based Nanomechanical Study of Ovarian Tissues with Pathological Conditions</p>

<p>An AFM-Based Nanomechanical Study of Ovarian Tissues with Pathological Conditions</p>

Metastatic Bilateral Strumal Carcinoid: A Case Report and Review of the Literature

Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study

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