Malignant Transformation of a Nevus of Ito: Description of a Rare Case

Martínez-Peñuela, Ana; Iglesias, M.E.; Mercado, María; Martínez-Peñuela, J.M.

doi:10.1016/j.adengl.2012.01.002

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Very rare cases of malignant transformation within existing Ito's nevi have been reported [19,29]. The clinical sign of melanoma within the existing Ito's nevus was a newly developed nodule [29].…”

Section: Ito's Nevus and Ota's Nevusmentioning

confidence: 99%

“…Ito's nevus (nevus fusco-coeruleus acromio-deltoideus or deltoideo-acromial melanocytosis) presents as a slate-blue/gray-blue macula in the shoulder/breast and lateral arm region in the supply area of the brachial nerve, in infants or until puberty [28]. Very rare cases of malignant transformation within existing Ito's nevi have been reported [19,29]. The clinical sign of melanoma within the existing Ito's nevus was a newly developed nodule [29].…”

Section: Ito's Nevus and Ota's Nevusmentioning

confidence: 99%

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The spectrum of melanocytic nevi and their clinical implications

Frischhut

Zelger

André

et al. 2022

J Deutsche Derma Gesell

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Summary The magnitude of the topic of melanocytic nevi (MN) is directly related to its relevance in everyday clinical work. The different MN have different prognostic significance in regard to comorbidity and possible risk of transformation. In addition to the criteria of the ABCDE rule, relevant criteria in the assessment of an MN are the time of occurrence, the growth tendency, the distribution and the comparison with other MN of the respective individual. The present CME article provides an overview of the knowledge that has been gained with regard to the development and genetic background of MN and any risk of degeneration that may exist. In addition, certain clinical and/or dermatoscopic features may provide the clinician with a decision‐making aid in the management of different MNs.

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Section: Ito's Nevus and Ota's Nevusmentioning

confidence: 99%

Section: Ito's Nevus and Ota's Nevusmentioning

confidence: 99%

The spectrum of melanocytic nevi and their clinical implications

Frischhut

Zelger

André

et al. 2022

J Deutsche Derma Gesell

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“…Weitere Manifestationen BAP1 Der Nävus Ito (Naevus fusco-coeruleus deltoideo-acromialis oder auch als deltoideoakromiale Melanozytose bezeichnet) präsentiert sich als schieferblaue/graublaue Makula an Schulter-, Brust-und seitlicher Armregion im Versorgungsgebiet des Nervus brachialis im Säuglingsalter oder bis zum Zeitpunkt der Pubertät [28]. In der Literatur finden sich sehr seltene Fälle von malignen Transformationen in einem präexistentem Nävus Ito [19,29]. Klinisches Merkmal für ein Melanom war ein neu entstandener Knoten im Bereich des vorbestehenden Nävus Ito [29].…”

Section: Gen Dermatologische Manifestationenunclassified

“…In der Literatur finden sich sehr seltene Fälle von malignen Transformationen in einem präexistentem Nävus Ito [19,29]. Klinisches Merkmal für ein Melanom war ein neu entstandener Knoten im Bereich des vorbestehenden Nävus Ito [29].…”

Section: Gen Dermatologische Manifestationenunclassified

Das Spektrum melanozytärer Nävi und deren klinische Bedeutung

Frischhut

Zelger

André

et al. 2022

J Deutsche Derma Gesell

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Zusammenfassung Die Größe der Thematik melanozytärer Nävi (MN) steht in einem direkten Verhältnis zur Relevanz in der alltäglichen klinischen Arbeit. Die klinische Präsentation ist hochgradig variabel und verschiedene MN haben unterschiedliche prognostische Bedeutung in Bezug auf Komorbidität und mögliches Entartungsrisiko. Relevante Kriterien in der Einschätzung eines MN sind neben den Kriterien der ABCDE‐Regel der Zeitpunkt des Auftretens des MN, die Wachstumstendenz, die Verteilung und der Vergleich mit anderen MN des jeweiligen Individuums. Es soll hier eine Übersicht gegeben werden, welche Erkenntnisse in Bezug auf die Entwicklung und genetischen Hintergründe MN und ein gegebenenfalls bestehendes Entartungsrisiko gewonnen werden konnten. Zudem können gewisse klinische und/oder dermatoskopische Merkmale dem Kliniker eine Entscheidungshilfe im Management unterschiedlicher MN liefern.

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“…While there have been a couple dozen cases of melanoma arising in blue nevi (often oxymoronically referred to as ‘malignant blue nevi’), we can identify only 13 reported cases of primary cutaneous melanoma arising in dermal melanocytoses. A total of 10 arose within nevi of Ota and 3 in nevi of Ito . In addition to these cutaneous melanomas arising in association with nevi of Ota and Ito, over 40 cases of primary melanoma of the uveal tract (choroid, iris and ciliary body), orbital soft tissues, central nervous system, meninges and dura have been reported in association with nevi of Ota .…”

Section: Summary Of Cases Of Primary Cutaneous Melanoma Arising In Thmentioning

confidence: 99%

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

et al. 2015

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Dermal melanocytosis refers to a spectrum of benign melanocytic proliferations that includes Mongolian spot, nevus of Ota and nevus of Ito. These lesions most commonly occur in persons of Asian or African descent and are often present at birth or develop during childhood. Very rarely, dermal melanocytoses undergo malignant transformation. There have been only 13 reports in the literature of primary cutaneous melanoma arising in dermal melanocytoses. We report a case of a Chinese woman with melanoma arising in a congenital nevus of Ito. We performed targeted next-generation sequencing of the tumor which revealed mutations of GNAQ and BAP1, suggesting that alterations in these two genes led to malignant transformation of the nevus of Ito. We also provide a summary of reports in the literature regarding primary cutaneous melanoma arising in the context of dermal melanocytosis.

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Malignant Transformation of a Nevus of Ito: Description of a Rare Case

Cited by 4 publications

References 9 publications

The spectrum of melanocytic nevi and their clinical implications

The spectrum of melanocytic nevi and their clinical implications

Das Spektrum melanozytärer Nävi und deren klinische Bedeutung

Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis

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