Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report and review of the literature

Bats, Anne-Sophie; Zafrani, Y.; Pautier, Patricia; Duvillard, P.; Morice, Philippe

doi:10.1016/j.fertnstert.2007.08.080

Cited by 66 publications

(87 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7 In our case, the mass appeared in the anterior wall of the abdomen without evidence of abdominal cavity involvement from abdominal CT. The abdominal wall itself was limited by the peritoneum.…”

Section: Discussionmentioning

confidence: 50%

“…On the other hand, although lymphatic dissemination may be present, it has only been reported in three cases. [7][8][9] At the time of the pre-surgical evaluation, it was difficult to make a diagnosis of lymph node involvement. However, the presence of lymph node enlargement in the inguinal region and in the external iliac chain was observed on CT scans.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report

et al. 2018

View full text Add to dashboard Cite

BACKGROUND: Malignant transformation of endometriosis in the abdominal wall is a rare and still poorly understood event. Less than 30 cases have been reported in the worldwide literature. Most cases of solid tumors are report in a previous abdominal scar with malignant transformation of a focus of endometriosis. Presence of lymph node metastases in nearby chains is frequent and is associated with poor prognosis. CASE REPORT: We report a case of a 42-year-old woman with a history of abdominal surgery (Pfannenstiel) to resect abdominal wall endometriosis. Physical examination revealed a solid mass of approximately 10 cm x 6 cm in the anterior wall of the abdomen. Computed tomography (CT) of the abdomen and pelvis showed a heterogeneous, predominantly hypoattenuating expansive formation measuring 10.6 cm x 4.7 cm x 8.3 cm. The patient underwent exploratory incisional laparotomy, block resection of the abdominal mass and lymphadenectomy of the external and inguinal iliac chains. The abdominal wall was reconstructed using a semi-absorbable tissue-separating screen to reconstitute the defect caused by resection of the tumor. Histological evaluation revealed infiltration by malignant epithelioid neoplasia, thus confirming the immunohistochemical profile of adenocarcinoma with clear cell components. Lymphadenectomy showed metastatic involvement of an external iliac chain lymph node. CONCLUSION: Resection of the mass along with the abdominal wall, with wall margins, is the most effective treatment. Reconstruction is a challenge for surgeons. The patient has been followed up postoperatively for eight months, without any evidence of disease to date. I MD. Resident Physician,

show abstract

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It is a chronic disease and the symptoms can signifi cantly aff ect the quality of life. Another important reason for surgical treatment is potential relapse or malignant transformation of AWE 3,4 . Th e incidence of AWE is 0.03%-2% after cesarean section.…”

Section: Discussionmentioning

confidence: 99%

“…Th ere is an increasing number of cesarean sections and so is the incidence of scar endometrioma as a potential complication of this procedure. Th ere are reports of malignant transformation of AWE 3,4 . Th erefore, it is important to recognize the condition and treat it surgically.…”

mentioning

confidence: 99%

Abdominal Wall Endometriosis Eleven Years After Cesarean Section: Case Report

Djaković

Vuković

Bolanča

et al. 2017

acc

View full text Add to dashboard Cite

SUMMARY -Endometriosis is a common chronic disease characterized by growth of the endometrial gland and stroma outside the uterus. Symptoms aff ect physical, mental and social well-being. Extrapelvic location of endometriosis is very rare. Abdominal wall endometriosis occurs in 0.03%-2% of women with a previous cesarean section or other abdominopelvic operation. Th e leading symptoms are abdominal nodular mass, pain and cyclic symptomatology. Th e number of cesarean sections is increasing and so is the incidence of abdominal wall endometriosis as a potential complication of the procedure. Th ere are cases of malignant transformation of abdominal wall endometriosis. Th erefore, it is important to recognize this condition and treat it surgically. We report a case of a 37-year-old woman with abdominal wall endometriosis 11 years after cesarean section. She had low abdominal pain related to menstrual cycle, which intensifi ed at the end of menstrual bleeding. A nodule painful to palpation was found in the medial part of previous Pfannenstiel incision. Ultrasound guided biopsy was performed and the diagnosis of endometriosis confi rmed. Surgery is the treatment of choice for abdominal wall endometriosis. Excision with histologically proven free surgical margins of 1 cm is mandatory to prevent recurrence. A wide spectrum of mimicking conditions is the main reason for late diagnosis and treatment of abdominal wall endometriosis. In our case, the symptoms lasted for eight years and had intensifi ed in the last six months prior to surgery.

show abstract

“…Ulrich U. et al [5] reported that the most frequent site in 139 cases of extra-ovarian cancer arising from endometriosis was the bowel (28%), followed by the rectovaginal septum (13%), uterus (arising from adenomyosis) (12%), peritoneum (6%) and others (such as broad ligament, parametrium, urinary bladder, and vagina) (44%). Reviews on the histology of malignant transformation in extra-ovarian endometriosis are primarily represented by endometrioid adenocarcinoma (69.1%), followed by sarcoma (25%) and clear cell carcinoma (4.5%) [6].…”

Section: Discussionmentioning

confidence: 99%

Endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar: A case report

Hayashi¹,

Shoda²,

Kosaka³

et al. 2013

OJOG

View full text Add to dashboard Cite

We report a very rare case of endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar. A 47-year-old woman visited the surgical department, since she had a gradually growing and painful tumor both in an appendectomy scar and at an umbilical site. She underwent appendectomy at age 18 years, and noticed the tumor at age 22 years. Partial tumor resection was performed in that department, and the pathology revealed endometrioid adenocarcinoma. She was referred to our department for radical therapy. Tumors in the both sites were dissected together with some swelling lymph nodes in our department. A pathological diagnosis of the tumor in the umbilical site showed only benign endometriosis. In contrast, the tumor in the appendectomy scar showed benign endometriosis, atypical endometriosis and well differentiated endometrioid adenocarcinoma. Resected lymph nodes also contained endometrioid adenocarcinoma, and were diagnosed as metastases. It was concluded that the endometrioid adenocarcinoma in the tumor of the appendectomy scar was a malignant transformation arising from abdominal wall endometriosis from the pathological findings. Since the operation, adjuvant and maintenance chemotherapy with paclitaxel and carboplatin had been administered for 3 years. She is free of disease 3.5 years after the operation.

show abstract

Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report and review of the literature

Cited by 66 publications

References 11 publications

Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report

Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report

Abdominal Wall Endometriosis Eleven Years After Cesarean Section: Case Report

Endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar: A case report

Contact Info

Product

Resources

About